adenosine A1 receptor
Engrailed homeoprotein recruits the adenosine A1 receptor to potentiate ephrin A5 function in retinal growth cones
... involves adenosine A1 receptor activation after Engrailed-dependent ATP synthesis, followed by ATP secretion and hydrolysis to ...the adenosine A1 receptor in axon ...the ...
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Circadian Variation of Antinociceptive Effect of Adenosine and Adenosine A1 Receptor Agonists, N6-Phenylisopropyl Adenosine and 2-Chloroadenosine, in Mice
... 11). Adenosine also regulates pain transmission by actions at spinal, supraspinal and peripheral sites through the activation adenosine A1 receptors and may play an important role in inflammatory and ...
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Evidence for deactivation of both ectosolic and cytosolic 5' nucleotidase by adenosine A1 receptor activation in the rat cardiomyocytes
... an adenosine A1 receptor ...A2 receptor agonist, nor cycloheximide deactivated ectosolic and cytosolic ...of adenosine A1 receptors is coupled to Gi proteins and attenuates ...
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<p>Podocyte Density and Albuminuria in Aging Diabetic Ins2± Mice with or Without Adenosine A1 Receptor Signaling</p>
... In our study, we focused on the correlation of a diabetic nephropathy phenotype with the podocyte numbers in two different Ins2± mice strains. Next to the well-characterized and commercially available (Jax laboratories) ...
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A systems pharmacology approach to the adenosine A1 receptor
... given receptor is often a function of the ...mammalian receptor- G protein ...to adenosine receptor signalling in yeast with a view to understanding the contribution of the ligand, ...
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Adenosine A1 receptor activation mediates the developmental shift at layer 5 pyramidal cell synapses and is a determinant of mature synaptic strength
... Double-exponential fits to a use-dependent blockade of NMDA-receptor-mediated currents (Cheetham & Fox, 2010; Gonzalez-Burgos et al. 2008) provided evidence for two populations of synapses with high and low ...
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Selective Inhibitory Effect of Adenosine A1 Receptor Agonists on the Proliferation of Human Tumor Cell Lines
... of adenosine receptor to different heteromeric G proteins: evidence for agonist-specific G protein ...the adenosine-activated signal transduction pathway conferring protection against iodoacetic ...
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Adenosine A1 receptor induced delayed preconditioning: Investigation of the time course and cellular mechanisms
... Introduction: Ischaemic heart disease is the leading cause of mortality and morbidity in the Western world. The possibility of exploiting an innate adaptive mechanism to protect ischaemic myocardium has generated ...
251
A role of p38 mitogen-activated protein kinase in adenosine A1 receptor-mediated synaptic depotentiation in area CA1 of the rat hippocampus
... NMDA receptor activation ...stimulate adenosine-mediated signaling pathways to trigger depotentiation ...of adenosine A 1 receptor activation to undergo the induction of ...mGlu ...
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A role for adenosine A1 receptor blockade in the ability of caffeine to promote MDMA "Ecstasy" induced striatal dopamine release
... While it has been reported that the inhibitory effect of caffeine on PDE is of little relevance at the concentrations of caffeine administered in vivo (Fredholm et al., 1999), the weak PDE inhibiting properties of ...
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Non-ribose ligands for the human adenosine A1 receptor
... of receptor to agonist results in a diminished functional response of the receptor upon prolonged agonist ...the receptor will disappear from the plasma membrane, it can remain their in the inactive ...
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The effect of receptor density on the binding and functional properties of the human adenosine A1 receptor
... The receptor must therefore work ‘at a distance’ to change the conformation of the protein by triggering an allosteric ...both receptor and Py from Ga-GTP (Coleman et al, 1994; Noel et al, ...
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Adenosine formed by 5′ nucleotidase mediates tubuloglomerular feedback
... of adenosine, which causes glomerular ...hypothesis. Adenosine activity was manipulated by microperfusing nephrons with adenosine A1 receptor blocker, A1-agonist, or ...
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Human mesenchymal stromal cells inhibit platelet activation and aggregation involving CD73-converted adenosine
... of adenosine by LC-MS/MS The samples were separated by HPLC (Agilent 1100, Waldbronn, Germany) using a LiChrospher 100 RP C-18, 5 μm column (125 mm × 4 mm) in combination with a gradient method of acetonitrile and ...
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A depletable pool of adenosine in area CA1 of the rat hippocampus
... the adenosine pool would be ...of adenosine may still be elevated (Valtysson et ...hr), adenosine levels may be at least partially ...extracellular adenosine rather than the induction of a ...
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Quantitative prediction of selectivity between the A1 and A2A adenosine receptors
... In addition to the availability of crystal structures, many small molecule ligands have been experimentally tested for their activity on one or multiple adenosine receptors. This data has already been exploited to ...
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Multiple components of the A1 adenosine receptor adenylate cyclase system are regulated in rat cerebral cortex by chronic caffeine ingestion
... antagonist radioligand [3H]xanthine amine congener (XAC). R-PIA (agonist) competition curves constructed with [3H]XAC were most appropriately described by a two affinity state model in control membranes with a KH of 2.1 ...
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Cordycepin modulate body weight by reducing
... anti-obesity effect of cordycepin by reducing prolactin release via an adenosine A1 receptor1. In vivo , 20.[r] ...
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Physiological role for P2X1 receptors in renal microvascular autoregulatory behavior
... P2X receptor family in a causative ...P2X receptor signals all resulted in blockade of pressure-mediated autoregula- tory responses (8, ...P2 receptor desensitization, satu- ration, or ...
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Structure-Affinity Relationships and Structure-Kinetics Relationships of Pyrido[2,1-f]purine-2,4-dione Derivatives as Human Adenosine A(3) Receptor Antagonists
... ABSTRACT: We expanded on a series of pyrido[2,1-f ]purine-2,4-dione derivatives as human adenosine A 3 receptor (hA 3 R) antagonists to determine their kinetic pro fi les and a ffi nities. Many compounds ...
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