Adenosine receptors (ARs)
Inosine binds to A3 adenosine receptors and stimulates mast cell degranulation
... A3 adenosine receptors (A3AR) with an IC50 of 25+/-6 microM; (b) not bind to A1 or A2A ARs; (c) bind to newly identified A3ARs in guinea pig lung (IC50 = 15+/-4 microM); (d) lower cyclic AMP in ...
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Squalene-Adenosine Nanoparticles: Ligands of Adenosine Receptors or Adenosine Prodrug?
... Adenosine receptors (ARs) represent key drug targets in many human pathologies, including cardiovascular, neurologic, and inflammatory ...of adenosine, metabolically stable AR agonists and ...
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Adenosine Receptors Machinery and Purinergic Receptors in Rat Primary Skeletal Muscle Cells
... is adenosine receptors, which are divided into A 1 , A 2A , A 2B and A 3 adenosine receptors based on pharmacology and coupling to cAMP ...of receptors is P2Y receptors, which ...
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Quantitative prediction of selectivity between the A1 and A2A adenosine receptors
... sine receptors (among others classification, regression, and we define different selectivity ...2A adenosine receptors was predicted effectively using the selectivity-window ...
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Adenosine receptors mediate synergistic stimulation of glucose uptake and transport by insulin and by contractions in rat skeletal muscle
... of adenosine receptors in the regulation of muscle glucose uptake by insulin and contractions was studied in isolated rat hindquarters that were perfused with a standard medium containing no insulin or a ...
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Effect of agonists of adenosine receptors on inflammatory markers in human Muller cells
... adenosine receptors. Recent studies have shown that inflammation plays a major role in the pathogenesis of diabetic retinopathy 29,30 . Several inflammatory markers have been reported which might be ...
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A1 and A2 adenosine receptors in rabbit cortical collecting tubule cells Modulation of hormone stimulated cAMP
... Adenosine analogs were used to investigate the cellular mechanisms by which adenosine may alter renal tubular function. Cultured rabbit cortical collecting tubule (RCCT) cells, isolated by immunodissection, ...
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Allosteric regulation of adenosine receptors
... coupled receptors (eg p-adrenoceptors and muscarinic receptors) it is commonly found that there is an apparent incomplete receptor-G protein coupling in the presence of agonist: the Hill slopes of ...
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Interactions between striatal dopamine and adenosine receptors: effects of aminophylline on a pharmacological model of parkinson's disease
... The most common hypokinetic motor disorder of NB is Parkinson's disease, characterized by (1) muscle stiffness that is present in all muscle groups, both flexors and extensors, which is usually accompanied by sudden ...
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Presynaptic muscarinic acetylcholine autoreceptors (M1, M2 and M4 subtypes), adenosine receptors (A1 and A2A) and tropomyosin-related kinase B receptor (TrkB) modulate the developmental synapse elimination process at the neuromuscular junction
... The BDNF-TrkB pathway also plays a biphasic role. Judg- ing from the effect of the TrkB-IgG chimera, BDNF initially delays elimination and subsequently accelerates it. Neuro- trophins and their receptors in muscle ...
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Adenosine A(2A) receptors control neuroinflammation and consequent hippocampal neuronal dysfunction
... et al. 2010) further argues for a direct ability of A2AR on microglia cells to control LPS-induced neuroinflammation. However, it remains to be determined if the A2AR mainly control the chemotaxis or the activation of ...
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Proteochemometric modeling in a Bayesian framework
... and adenosine receptors binding sites, as well as the Dengue virus NS3 proteases substrates, were described with five amino acid extended principal property scales (5 ...
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Caffeine alters the effects of bone marrow-derived mesenchymal stem cells on neutrophils
... It has been shown that mesenchymal stem cells (MSCs) express all four adenosine receptors’ subtypes, and stimulation of these receptors plays an active role in bone marrow-derived mesen[r] ...
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A1 adenosine receptor attenuates intracerebral hemorrhage-induced secondary brain injury in rats by activating the P38-MAPKAP2-Hsp27 pathway
... We first performed a time course experiment (Fig. 1). After establishment of the ICH model, rats were killed at the following time points after induction of ICH: 0 h, 6 h, 12 h, 24 h, 48 h, 72 h, and 1 week. In western ...
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Inhibition of lipolysis by adenosine is potentiated with age
... released adenosine accounts for the diminished lipolysis. Adenosine deaminase was added to media containing the adipocytes from older rats to remove endogenous ...The adenosine analogue ...
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Adenosine A2 Receptor: Novel Target for the Management of Parkinsonism
... of adenosine A2A receptors in basal ganglia that are richly innervated by dopamine, and their antagonistic role towards the stimulation of dopamine receptors, have positioned A2A receptor antagonists ...
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The adenosine/neutrophil paradox resolved: human neutrophils possess both A1 and A2 receptors that promote chemotaxis and inhibit O2 generation, respectively
... specific receptors on neutrophils by adenosine or its analogues diminishes the stimulated release of toxic oxygen metabolites from neutrophils, while paradoxically promoting ...distinct adenosine ...
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Cardiac myocyte–secreted cAMP exerts paracrine action via adenosine receptor activation
... through adenosine receptors, and if others exist, are they relevant? Other candidates for paracrine signaling are ATP and cGMP (28, 29), but several aspects argue against a relevance for these nucleotides ...
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Impaired vasocontractile responses to adenosine in chorionic vessels of human term placenta from pregnant women with pre existing and gestational diabetes
... of adenosine-induced vasocontraction in human chorionic ...to adenosine in chorionic vessels from pregnan- cies complicated by both pregestational and gestational ...to adenosine in both chori- onic ...
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The α1A/C and α1B adrenergic receptors are required for physiological cardiac hypertrophy in the double knockout mouse
... Finally, the male ABKO heart not only was small but also had abnormal function. Contractile function in vivo at rest was intact, with normal ejection fraction and fractional shortening by echocardiography. However, ...
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