Aggressive phenotype
PRKC-ζ Expression Promotes the Aggressive Phenotype of Human Prostate Cancer Cells and Is a Novel Target for Therapeutic Intervention.
... In addition to a functionally-competent locomotor assembly, maintenance of cell polarity and loss of cell-cell adhesion are essential for cell migration 47 . For a cell to migrate, generation of a forward-rear polarity ...
25
DNA Hypomethylation Mediated Overexpression of Carbonic Anhydrase 9 Induces an Aggressive Phenotype in Ovarian Cancer Cells
... an aggressive cancer cell ...an aggressive phenotype, including increased invasiveness and migration, in SK-OV-3 ...more aggressive phenotype in ovarian can- cer ...
8
SATB1 Protein Is Associated with a More Aggressive Phenotype of Sporadic Colorectal Cancer
... Objective: SATB1 is a genome organizer known for its role in T-cell development. With its cage-like, nuclear archi- tecture regulates a number of genes through epigenetic modifications. Ectopic expression of SATB1 has ...
10
MicroRNA-224 sustains Wnt/β-catenin signaling and promotes aggressive phenotype of colorectal cancer
... We showed that miR-224 has the ability to promote CRC cell growth and invasion, which are the basal behavior in CRC metastasis, through directly activating Wnt/β-catenin signaling by tar[r] ...
11
SMYD3 contributes to a more aggressive phenotype of prostate cancer and targets Cyclin D2 through H4K20me3
... that are most likely to cause clinically aggressive disease. Since current clinical and pathological parameters have a limited ability to discriminate between clinically significant and insignificant PCa, emphasis ...
14
siRNA Knockdown of Ribosomal Protein Gene RPL19 Abrogates the Aggressive Phenotype of Human Prostate Cancer
... cellular phenotype of eukaryotic cells remains unclear, current evidence reveals mutations within individual ribosomal proteins to be associated with specific changes in cellular phenotype [71,72] rather ...
16
Met regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotype
... Functional analysis of target genes confirms the role of Met as an essen- tial regulator of cell motility. In accordance with previous studies, we detected significant changes in the expression levels of known Met target ...
15
<p>Matrix metalloproteinase 2 contributes to aggressive phenotype, epithelial-mesenchymal transition and poor outcome in nasopharyngeal carcinoma</p>
... between MMP-2 and EMT in cancer progression. Actually, experimental data has shown that cancer cells that undergo EMT can enhance MMP-2 expression to facilitate cell inva- sion and metastasis. 42–44 In the current study, ...
11
Original Article Myelin expression factor 2 expression is associated with aggressive phenotype in triple-negative breast cancer
... an aggressive clinical course with frequent re- currence and short survival and an absence of molecular ...with aggressive phenotypes of TNBC, such as larger tumor size, high AJCC stage, and Ki-67 ...
6
PRKC-ζ Expression Promotes the Aggressive Phenotype of Human Prostate Cancer Cells and Is a Novel Target for Therapeutic Intervention.
... knockdown phenotype to be distinct and further shifted from the parental PC3-M cells than the non-malignant PNT-2 cells, thus confirming modulation of the malignant phenotype through down-regulation of ...
25
MDM2 SNP309 and MDM2 protein levels in prostate cancer (PCa) patients of different racial
... an aggressive prostate cancer ...of aggressive disease among a cohort of patients already diagnosed than as a predictor of PCa risk in the population ...with aggressive disease at onset or with the ...
8
Download Download PDF
... Background: Genetic evidence has established a role of nuclear factor kappa B (NF-κB) signaling in oncogenesis. However, activity of NF-κB in complete hydatidiform mole (CHM) cell culture under 17β-estradiol (E2) ...
5
Capsaicin triggers autophagic cell survival which drives epithelial mesenchymal transition and chemoresistance in bladder cancer cells in an Hedgehog-dependent manner
... more aggressive phenotype, reduced survival and poor prognosis ...invasive phenotype and poorer outcome in BC ...EMT phenotype and drug resistance found in CPS-treated BC ...
15
Loss of Wave1 gene defines a subtype of lethal prostate cancer
... an aggressive phenotype, we observed significant down regulation of the putative tumor suppressors CHD1 and CDH10 (cadherin-10) [59, ...WASF1-low phenotype, we observed negative enrichment for ...
9
Original Article Upregulation of miR-150 expression as a poor prognostic marker for cervical cancer patients
... In conclusion, our data demonstrated that upregulation of miR-150 expression is associated with an aggressive phenotype and poor prognosis in cervical cancer patients and miR150 may serv[r] ...
6
H19 non coding RNA-derived miR-675 enhances tumorigenesis and metastasis of breast cancer cells by downregulating c-Cbl and Cbl-b
... In this study, we have examined the role of H19- derived miR-675 in controlling the properties of breast cancer cells. Using in silico prediction and functional assays, we identified c-Cbl and Cbl-b as direct targets of ...
15
Original Article Are synchronous and metachronous bilateral breast cancers different? An immunohistochemical analysis aimed at intrinsic tumor phenotype
... basal-like phenotype, but reported expression frequency in this population varies between 25 and 100%, as compared to 4-23% in tumors unselected for intrinsic phenotype ...more aggressive ...
11
Membrane transport proteins in human melanoma: associations with tumour aggressiveness and metastasis
... more aggressive nature of ...more aggressive phenotype of melanoma, together with the significantly higher prevalence of these pumps (MRP-1, in particular) in metastases compared with primary ...
6
Original Article Expression of Eag1 K+ channel and ErbBs in human pituitary adenomas: cytoskeleton arrangement patterns in cultured cells
... with aggressive pituitary adenoma behavior [14-16, ...other aggressive tumors and carcinomas ...tumor aggressive pheno- type [24, ...the aggressive phenotype in the pituitary adenomas, ...
11
Immunoprofile from tissue microarrays to stratify familial breast cancer patients
... together with the analysis of marker distributions between patient clusters, allowed us to identify a minimal set of 10 significant biomarkers necessary to define more precisely the patient cluster groups. In particular, ...
15