Aging and Life Span
Aging-related elevation of sphingoid bases shortens yeast chronological life span by compromising mitochondrial function
... in aging in ...yeast aging nor how they, in turn, regulate ...the aging process and that SBs shortens chronological life span (CLS) by compromising mitochondrial ...of aging. ...
21
The Short Life Span of Saccharomyces cerevisiae sgs1 and srs2 Mutants Is a Composite of Normal Aging Processes and Mitotic Arrest Due to Defective Recombination
... Evidence from many organisms indicates that the conserved RecQ helicases function in the maintenance of genomic stability. Mutation of SGS1 and WRN, which encode RecQ homologues in budding yeast and humans, respectively, ...
12
Life-span Extension With Reduced Somatotrophic Signaling: Moderation of Aging Effect by Signal Type, Sex, and Experimental Cohort.
... delay aging, although the degree of life-extension varies markedly across ...relative life- ...median life span than IGF1 manipulations (including IGF1 production, reception, and ...
8
The Association of Gender, Age, and Coping with Internalizing Symptoms in Youth with Sickle Cell Disease
... this particular residue and renders it active (Westerheide et al 2009, Raynes et al 2012). We first demonstrated that Daphnia Sir2 is functionally conserved, being able to protect cells from proteotoxic stress and ...
206
Alzheimer's disease in humans and other animals : a consequence of postreproductive life span and longevity rather than aging
... For a failure of insulin signaling to effect the risk of AD directly rather than through a mediating factor such as vascular damage, then insulin resistance in the periphery should be reflected in insulin resistance in ...
24
A mother's sacrifice: what is she keeping for herself?
... their life span [12], and limiting ERC formation extends life span [14], strongly supporting the idea that ERC accumulation has a causal role in replicative ...replicative aging more ...
13
Essential role for autophagy in life span extension
... the life span of yeast, flies, and nematodes (Figure 3 and ...the life span of mice fed a high-fat, Western-style diet (70, ...prolongs life span of yeast, flies, and nematodes ...
10
Quantitative Genetics and Genomics of Drosophila Life Span
... limited life span and senescence are controlled by many interacting quantitative trait loci (QTLs) with individually small effects, whose expression is sensitive to the ...limit life span and ...
3269
Ovariectomy shortens the life span of female mice
... Estrogens regulate energy metabolism in several organs, including the liver, where these hormones strongly influence lipid and cholesterol metabolism [18, 19]. In fact, ovx in mice and menopause in women are associated ...
11
Different Mechanisms of Longevity in Long-Lived Mouse and Caenorhabditis elegans Mutants Revealed by Statistical Analysis of Mortality Rates
... for aging research would demonstrate a similar invariance for G with increased life ...of aging (Antebi 2007; Li and Ren 2007; Van Raamsdonk and Hekimi ...All life span experiments were ...
58
Nutritional Control of Chronological Aging and Heterochromatin in Saccharomyces cerevisiae
... yeast aging that responds to nutrient cues in- cluding, but not limited to, ...chronological life span in response to changes in ...chronological life span, often independent of the ...
15
Thermodynamics of the origin of life, evolution, and aging
... of life and others) affect the life span of living beings according to the thermodynamic theory of ...long life expectancy of a naked mole-rat (Heterocephalus glaber) is essentially dependent ...
15
Rapalogs and mTOR inhibitors as anti aging therapeutics
... that life span extension by rapamycin is second- ary to tumor suppression and unrelated to the underlying aging ...the life spans of the longest-lived individuals in a group, as the oldest ...
11
A Reassessment of Genes Modulating Aging in Mice Using Demographic Measurements of the Rate of Aging
... mouse life span; however, it is crucial to discriminate between manipulations of aging and aging-independent causes of life ...reported aging-related mouse genes statistically ...
14
Genetic Analysis of Tissue Aging in Caenorhabditis elegans: A Role for Heat-Shock Factor and Bacterial Proliferation
... proliferation. This suggests that, as the animal ages, it Because daf-2 mutants live 100% longer than normal, loses the capacity to prevent bacterial proliferation in its much longer than the 30–40% extension conferred ...
12
Public Health and the Aging Family
... the aging family, recognizing that the family is one of the earliest and longest lasting contexts influencing ...a life span and life course perspective, recognizing that individuals develop ...
20
Molecular characterization and rescue of acatalasemic mutants of Drosophila melanogaster.
... SETO, HAYASHI and TENER (1 990) examined the effects of increasing Cu/ Zn superoxide dismutase levels on aging in Drosophila and found that, if affected at all, life span was [r] ...
8
Early life effects on aging
... of aging with perfect repair and regen- eration processes does not occur because the energy requirements would jeopardise reproduction and therefore not be of evolutionary benefit ...
16
Life span of in vitro differentiated Plasmodium falciparum gametocytes
... Even though gametocytes have a long life-span in vitro, their half-life (50% survival rate) was short (2.6–6.5 days), similar to the result shown in a previous in vivo study (2.4 days) [9]. The peak ...
10
Birth Weight and Future Life-span in Finnish Triplets
... Scientists have studied the distribution of birth weight extensively. Recorded birth weight data showed skewing from the normal distribution. Erkkola et al. compared perinatal and neonatal mortality rates in different ...
9