Airway Surface Liquid
Airway surface liquid contains endogenous DNase activity which can be activated by exogenous magnesium
... luminal surface might also improve mucociliary clearance in CF patients by inhibiting the CF specific increased ab- sorption of Na+ and fluid across airway ...across airway epithelia resulting in an ...
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Acidic pH increases airway surface liquid viscosity in cystic fibrosis
... Cystic fibrosis (CF) disrupts respiratory host defenses, allowing bacterial infection, inflammation, and mucus accumulation to progressively destroy the lungs. Our previous studies revealed that mucus with abnormal ...
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Effect of vitamin D3 on the antimicrobial activity of human airway surface liquid: preliminary results of a randomised placebo-controlled double-blind trial
... that airway epithelial cells exposed to CSE and supplemented with 25(OH)D 3 had a smaller increase in CAMP gene expression compared with unexposed cells (figure ...ASL, airway surface liquid; ...
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Ion composition of airway surface liquid of patients with cystic fibrosis as compared with normal and disease control subjects
... between surface liquid collected from nasal surfaces of CF and normal subjects under basal ...Nasal surface liquid is close to ...of airway surface liq- uids from bronchial ...
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Determination of rheology and surface tension of airway surface liquid: a review of clinical relevance and measurement techniques
... the airway lining layer and the alveolar lining layer as airway surface liquid ...of airway surface liquid have a significant impact on normal respiratory mechanics and ...
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A pilot study of an in-vitro bovine trachea model of the effect of continuous positive airway pressure breathing on airway surface liquid
... The airway surface liquid (ASL) lining the upper respiratory tract has an essential role in heat and moisture exchange, as well as having an important role in airway ...The airway lumen ...
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Ivacaftor-induced sweat chloride reductions correlate with increases in airway surface liquid pH in cystic fibrosis
... (CFTR) anion channel function causes cystic fibrosis (CF), and lung disease produces most of the mortality. Loss of CFTR-mediated HCO 3 – secretion reduces the pH of airway surface liquid (ASL) in ...
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Noninvasive in vivo fluorescence measurement of airway surface liquid depth, salt concentration, and pH
... The airway-surface liquid (ASL) is the thin layer of aque- ous fluid that coats the airway mucosal surface. The ASL contains salts and a variety of macromolecules to carry out ...
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A novel fluorescent sensor protein for detecting changes in airway surface liquid glucose concentration
... luminal surface of the epithelium [airway surface liquid (ASL)], which is important for lung defence against ...upper airway, glucose concentrations are normally ∼ ...during ...
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Airway surface liquid from smokers promotes bacterial growth and biofilm formation via iron-lactoferrin imbalance
... selected exceptions, were pregnant, breast-feeding, had asthma, diabetes, heart disease or allergy to lidocaine. More detailed inclusion and exclusion criteria for this study were previously published [33]. The ...
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Modeling the airway surface liquid regulation in human lungs
... Epithelial cells make up the lining of the lungs, pancreas, liver, digestive tract and reproductive system, and are also found in the sweat glands and sinuses. As mentioned earlier, one of the symptoms of CF is to have ...
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17β Estradiol inhibits Ca2+ dependent homeostasis of airway surface liquid volume in human cystic fibrosis airway epithelia
... inhibited Ca 2+ signaling and ASL volume homeostasis in non-CF and CF airway epithelia by attenuating Ca 2+ influx. This inhibition of Ca 2+ signaling was prevented and even potentiated by estrogen antagonists ...
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Inhaled protein/peptide-based therapies for respiratory disease
... inhibitory domain, which for historical reasons was called the S18 region [29]. Unlike traditional ion channel antagonists which block ENaC’s pore, SPLUNC1 in- hibits ENaC by inducing endocytosis [54] (Fig. 1a). Since ...
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Hypertonic Saline and Acute Wheezing in Preschool Children
... triggered airway illnesses result from intermittent catastrophic failure of mu- cus clearance (MC) due to dehydration of the airway surface liquid ...luminal surface of the epithelial ...
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ajplung.00546.2016.pdf
... in airway surface liquid volume, leading to decreased mucocilliary clearance, chronic bacterial infection, and lung ...restores airway surface liquid height for up to 24 h in CF ...
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Coordinated clearance of periciliary liquid and mucus from airway surfaces
... Airway surface liquid is comprised of mucus and an under- lying, watery periciliary liquid ...along airway sur- faces via ciliary action, theoretical analyses predict that the PCL is ...
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Macrorheology of cystic fibrosis, chronic obstructive pulmonary disease & normal sputum
... popular airway surface liquid (ASL) volume theory [1,2] predicts that dehydrated, thickened respiratory secretions are integral to mucociliary stasis and the subsequent development of CF ...
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The SPLUNC1-βENaC complex prevents Burkholderia cenocepacia invasion in normal airway epithelia
... maintains airway hydration through negative regulation of the epithelial sodium channel ...to airway surface liquid (ASL) dehydra- tion and in chinchilla models decreases mucociliary clearance ...
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Mellnik_unc_0153D_15533.pdf
... the airway surface liquid have reassembled to formed a new mesh network in the background ...the airway surface liquid or an increase in the local elasticity of the background ...
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Cystic fibrosis and estrogens: a perfect storm
... of airway surface liquid homeostasis Which kind of ion channel is most impor- tant for periciliary ion and water content — CFTR, CaCC, or ENaC? This debate contin- ues to ...from airway ...
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