Akt signalling
Necessity to evaluate PI3K/Akt signalling pathway in proarrhythmia
... PI3K/Akt signalling pathway (figure 2) appears to offer some potential approach in addressing ...the signalling pathway better in arrhythmogenesis is criti- cally ...PIP3 signalling may cause ...
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BCL 3 expression promotes colorectal tumorigenesis through activation of AKT signalling
... which AKT activity can be increased in colorectal epithelial cells; our results suggest that potentiation of AKT sig- nalling (observed in both adenoma-derived RG/C2 and fi ve carcinoma-derived cell lines) ...
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EGF-activated PI3K/Akt signalling coordinates leucine uptake by regulating LAT3 expression in prostate cancer
... factor signalling pathways play an instructive role in regulating nutrient transporters via PI3K/Akt, which in- duces the phosphorylation and translocation of glucose transporter 1 (GLUT1) to cell surface ...
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Dioscin Induces Gallbladder Cancer Apoptosis by Inhibiting ROS-Mediated PI3K/AKT Signalling
... that AKT activity was significantly downregulated after DSN treatment, and that inhibition/ectopic expression of AKT enhanced/abolished DSN-induced apoptosis but not ...
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Exosomes derived from Wharton's jelly of human umbilical cord mesenchymal stem cells reduce osteocyte apoptosis in glucocorticoid-induced osteonecrosis of the femoral head in rats via the miR-21-PTEN-AKT signalling pathway
... PI3K-AKT signalling pathway, and the AKT inhibitor MK-2206 was used to investigate the expression of related ...on AKT (Thr308 and Ser473), and then caspase 3 was cleaved, leading to ...the ...
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p38 MAPK and PI3K/AKT signalling cascades in Parkinson’s disease
... and signalling networks, and accruing genetic studies in recent years have advocated prominently on the role of improper phosphorylation events, dysfunctional kinases, and aberrantly functioning kinases associated ...
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The role of Akt signalling in the mammalian ovary
... that Akt inhibition induces failure of MI itself, and that at MII stage Akt control polar body 2 emission and normal chromosomal alignment on microtubules (Hoshino and Sato, ...phosphorylated ...
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IGF1R signalling in testicular germ cell tumour cells impacts on cell survival and acquired cisplatin resistance.
... reduced AKT signalling in response to decreased IGF1R expression as well as sensitivity to the small-molecule IGF1R inhibitor ...IGF1R signalling via AKT and was one of the two cell lines ...
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The T-box transcription factor, TBX3, is a key substrate of AKT3 in melanomagenesis
... PI3K/AKT signalling pathway contributes to intrinsic resistance through suppressing apoptosis and oncogene induced senescence ...PI3K/AKT signalling have therefore been suggested because it ...
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The Akt1/IL-6/STAT3 pathway regulates growth of lung tumor initiating cells
... Akt2 signalling in NSCLC ...of Akt signalling in NSCLC TICs (not ...all Akt isoforms (MK2206) and an inhibitor of the most important upstream activator of Akt (LY294002) to determine ...
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The impact of immobilisation and inflammation on the regulation of muscle mass and insulin resistance: different routes to similar end points
... insulin signalling in ...mutual signalling events that may explain dysregulation of muscle protein and carbohydrate metabolism in ...discussed, Akt signalling appears to be crucial in ...
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Urinary proteomics of Henoch-Schönlein purpura nephritis in children using liquid chromatography-tandem mass spectrometry
... variety of enriched pathways are involved in HSPN, such as focal adhesion, cell adhesion molecules, the PI3K- Akt signalling pathway, ECM-receptor interactions and regulation of the ac[r] ...
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Titration of signalling output: insights into clinical combinations of MEK and AKT inhibitors.
... in signalling pathways [21], and future work will be better done in speci fi c disease con- ...study AKT inhibition as allosteric and ATP competitive drugs used to inhibit AKT caused diamet- rically ...
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Stimulus-dependent differences in signalling regulate epithelial-mesenchymal plasticity and change the effects of drugs in breast cancer cell lines
... TGF-beta signalling components was observed with EGF induced EMT within the PMC42-LA cells, and in the absence of EGF, components of the Wnt signalling path- way showed strong differences in transcript ...
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GC selective DNA binding antibiotic, Mithramycin A, reveals multiple points of control in the regulation of Hdm2 protein synthesis
... mutation of other sequences had differential effects between cell lines. These included the 50 b.p. region between -160 and -110, removal of which had no effect in MDA- MB231 cells, but approximately doubled activity in ...
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MDA19, a novel CB2 agonist, inhibits hepatocellular carcinoma partly through inactivation of AKT signaling pathway
... the AKT signalling pathway, could be reversed by CB2 ...of AKT signalling pathway in HCC, therefore MDA-19 treatment may be a promising strat- egy for HCC ...
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Neuroprotective Mechanisms of Orientin against Hydrogen Peroxide-induced Oxidative Damage in SH-SY5Y Cells
... Since oxidative stress has been highly implicated in the aetiology of AD and PD [16, 44], direct therapeutic approaches targeting oxidative events are crucial for the AD and PD patients [44, 45]. In this study, ...
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Celecoxib analogues disrupt Akt signaling, which is commonly activated in primary breast tumours
... inhibited Akt phosphorylation and Akt kinase ...of Akt (GSK and ...often Akt is activated in pri- mary tumours to estimate the number of patients that might benefit from these small molecule ...
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Investigating inherent functional differences between human cardiac fibroblasts cultured from nondiabetic and Type 2 diabetic donors.
... Fig. 2. Influence of T2DM on insulin-induced Akt and ERK phosphorylation. Cells cultured from 5 non-diabetic donors (filled circles) and 5 T2DM donors (open squares) were treated with 100 nM insulin for 5-60 min ...
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The role of c-Kit and insulin receptor tyrosine kinases in beta cell function and insulin secretion
... intracellular signalling, and examining the interplay of receptor activation and signalling in beta cells could provide information for the development of future ...
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