AL amyloidosis
AL Amyloidosis
... diagnosed AL amyloidosis were ran- domly assigned to receive intravenous high-dose melpha- lan (200 mg/m 2 , tapered down to 140 mg/m 2 in patients aged over 65 years and in those with advanced heart, ...
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Chronic diarrhea as the presenting feature of primary systemic AL amyloidosis: serendipity or delayed diagnosis?
... Case presentation: A 43-year-old man with chronic diarrhea and weight loss was referred to our hospital. Prior to his presentation, extensive evaluation including an exploratory laparotomy was carried out and did not ...
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Light chain (AL) amyloidosis: update on diagnosis and management
... whether this elevation represents true cardiac toxicity, fluid retention or is entirely clinically insignificant. How- ever, it makes assessing organ response very challenging. Targeting the proteasome, the cellular ...
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Renal-limited AL amyloidosis – a diagnostic and management dilemma
... showed AL amyloidosis with no evidence of free light chain deposition (as evidenced by the Congo red staining and negative for other specific ...primary amyloidosis failed to show any association ...
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Content validation of the SF-36v2® health survey with AL amyloidosis patients
... Cognitive debriefing interviews with patients followed a standard, in-person, in-depth interview method that has been developed for the SF-36v2 [22]. Each interview began with general questions regarding the impact of ...
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<p>Treatment Options For Relapsed/refractory Systemic Light-Chain (AL) Amyloidosis: Current Perspectives</p>
... Based on these encouraging data using single-agent daratumumab, this monoclonal antibody has now been used as part of combination regimens in AL amyloidosis, as is typically done in multiple myeloma. A ...
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Effectiveness of Bortezomib in Cardiac AL Amyloidosis: A Report of Two Cases
... in AL amyloidosis improving cardiac function and ...cardiac amyloidosis treated by bortezomib who experienced partial or total remission of hematologic disease and of cardiac ...
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Systemic AL Amyloidosis of the Tracheobronchial Tract and Lungs: a Rare Finding
... of AL amyloidosis of the bronchial tract was ...revealed AL amyloidosis associated with chronic sialadenitis type 3 of the Chisholm’s classification (Figure ...
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Significant association between renal function and amyloid-positive area in renal biopsy specimens in AL amyloidosis
... AL amyloidosis can be classified as either primary amyl- oidosis or secondary to multiple myeloma, on the basis of the number of plasma cells in the bone marrow and/ or the presence or absence of skeletal ...
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AL amyloidosis with non-amyloid forming monoclonal immunoglobulin deposition; a case mimicking AHL amyloidosis
... renal amyloidosis due to lymphoplasmacytic lymphoma secreting monoclonal immunoglobulin M ...was AL amyloidosis with non-amyloid forming monoclonal immunoglobulin ...classify amyloidosis, ...
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Recurrent Syncope, a Clue in Amyloid Cardiomyopathy
... If AL amyloidosis is present, immunofixation usually demonstrates a monoclo- nal band, and serum-free light chains show an abnormal kappa/lambda ratio in more than 90% of patients ...definitive AL ...
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18F-fluorodeoxyglucose positron emission tomography might be useful for diagnosis of hepatic amyloidosis
... of the plasma cells was confined to bone marrow, and there was no evidence of extramedullary plasmacytoma, obvi- ous lymph node enlargement, or plasma cell infiltration other than in bone marrow. The amyloid itself was ...
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Concurrent nephrotic syndrome and acute renal failure caused by chronic lymphocytic leukemia (CLL): a case report and literature review
... (LCDD), AL, membranoproliferative glomerulonephritis (MPGN) [11], membrane nephropathy (MN) and minimal change dis- ease (MCD) have been reported, which suggests the pre- sence of various pathogenesis pathways of ...
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The lung in amyloidosis
... pulmonary amyloidosis are the result of an underlying lymphoproliferative disorder in the spectrum of extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) ...systemic ...
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Key words
... of aL am- yloidosis running without symptomatic myelo- ma ...In amyloidosis without evidence of pro- liferation of plasma cells, lambda chain is more common (1:3), which according to some authors, suggests ...
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Key words
... 18 amyloidosis patients, among whom there were 12 and 6 patients with kappa and lambda chains respectively, sFLC concentrations were observed to be significantly higher than in patients without ...in AL ...
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Clinical management of gastrointestinal amyloidosis
... of amyloidosis treatment should be di- rected at the underlying cause, and aimed to arrest amy- loid accumulation and formation by reducing the abun- dance of the fibril precursor ...primary amyloidosis is ...
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Systemic AA amyloidosis: epidemiology, diagnosis, and management
... of amyloidosis is estimated at five to nine cases per million ...(AA) amyloidosis is more common in some European regions and in developing ...AA amyloidosis has changed in recent decades owing to: ...
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Vol 6 (2016)
... with AL amyloidosis, more consistent application of existing criteria into clinical practice could increase early diagnosis of cardiac involvement and provide opportunity for interventions including ...
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Review of eprodisate for the treatment of renal disease in AA amyloidosis
... primary AL amyloidosis and treatment of the underlying inflammatory condition in secondary AA amyloidosis, leading to a marked reduction in the production of the precursor amyloidogenic ...
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