All-Trans Retinoic Acid
All trans retinoic acid modulates the retinoic acid receptor alpha in promyelocytic cells
... that all-trans retinoic acid (RA), the active metabolite of vitamin A, is an efficient alternative to chemotherapy in the treatment of acute promyelocytic leukemia ...the retinoic ...
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Development of a novel microemulsion for oral absorption enhancement of all-trans retinoic acid
... Abstract: This study was aimed to develop a novel microemulsion that contained oleth-5 as a surfactant to enhance the oral absorption of all-trans retinoic acid (ATRA). The prepared ...
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All Trans Retinoic Acid Has a Potential Therapeutic Role for Diabetic Nephropathy
... nificant difference in weights among the three groups prior to 28 weeks. After 28 weeks of age, the OLETF rats weighed more than the LETO rats of the same age, while there was no statistical difference in weights be- ...
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CRABP-II- and FABP5-independent responsiveness of human glioblastoma cells to all-trans retinoic acid
... Glioblastomas respond differently to all-trans retinoic acid (RA) for unknown reasons. Because CRABP-II and FABP5 mediate RA intracellular signaling respectively and lead to distinct ...
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Selenite promotes all- trans retinoic acid-induced maturation of acute promyelocytic leukemia cells
... with all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) have dramatically improved the survival of APL patients with higher percentage of complete remission ...
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Effect of L-Ascorbic Acid and All-trans Retinoic Acid on Smooth Muscle Cells Cultured on PCL Scaffolds
... -Ascorbic Acid (AA) addition, a main challenge of VTE is an inability to understand and promote ...is all-trans retinoic acid (atRA) that is a derivative of vitamin A and essential ...
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Analysis of the role of thrombomodulin in all-trans retinoic acid treatment of coagulation disorders in cancer patients
... All-trans retinoic acid (RA) plays key roles in cancer treat- ment and prevention. Breast, lung, bladder, prostate, and acute promyelocytic leukemia (APL) cancers were shown to be suppressed ...
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Granulocyte colony-stimulating factor potentiates all-trans retinoic acid-induced granulocytic differentiation in acute promyelocytic leukemia cell line HT93A
... Granulocyte colony-stimulating factor (G-CSF) is a myeloid growth factor that promotes proliferation, survival, and differentiation of myeloid-lineage leukemic cells, as well as normal hematopoietic cells [1,2]. Clinical ...
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All trans retinoic acid stimulates synthesis of cyclic ADP ribose in renal LLC PK1 cells
... Cyclic adenosine diphospho-ribose (cADPR) triggers Ca2+ release from intracellular stores and is therefore proposed to function as a second messenger in cellular signaling; however, an extracellular stimulus, i.e., first ...
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Potential for combined delivery of riboflavin and all trans retinoic acid, from silk fibroin for corneal bioengineering
... Millions of people worldwide su ff er from vision impairing conditions resulting from corneal injury or disease. Silk fibroin (SF) is an emerging biopolymer that has been used for several applications including the ...
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Nanoparticle delivery and combination therapy of gambogic acid and all-trans retinoic acid
... gambogic acid (GA) and all-trans retinoic acid (ATRA), our strategy was to entrap GA in the self-assembled nanopar- ticles based on amphiphilic hyaluronic acid (HA)-ATRA (HRA) ...
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Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer
... that all-trans retinoic acid (ATRA)--a therapy for acute promyelocytic leukemia (APL) that is considered the first example of targeted therapy in cancer, but its drug target remains ...
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The combination of valproic acid, all-trans retinoic acid and low-dose cytarabine as disease-stabilizing treatment in acute myeloid leukemia
... valproic acid plus ATRA alone, and we observed a similar increase in our previous study during treatment with ATRA plus valproic acid plus theophylline ...
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Effect of all-trans retinoic acid on the proliferation and differentiation of brain tumor stem cells
... to all, EGF and bFGF, as powerful promo- ters of cell division, are essential key components in stem cell culture medium, and enable stem cells to proliferate ...
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All-trans retinoic acid and rapamycin normalize Hutchinson Gilford progeria fibroblast phenotype
... All samples at the end of the 28 days of treatment were harvested and washed in PBS twice while maintained in ice. Cell pellets were lysed by the addition of 0.5 ml of TRIzol reagent (Invitrogen). RNA was ...
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A fourth subtype of retinoic acid receptor-related orphan receptors is activated by oxidized all-trans retinoic acid in medaka (Oryzias latipes)
... All of the animal experiments described below were con- duct in compliance with institutional guidelines and ap- proved by the Animal Experiment Committee of Nagahama Institute of Bio-Science and Technology. ...
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THE EFFECT OF ALL-TRANS RETINOIC ACID AND FATTY ACIDS ON MCF-7 BREAST CANCER CELL PROGRESSION
... fatty acid is paramount in relation to breast ...linolenic acid found in fish oil inhibited the progression of mammary carcinogenesis (Rose et ...linoleic acid has also inhibitory effects on breast ...
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Original Article MiR-140-5p suppresses the adipogenic differentiation of mesenchymal stem cells in rats with steroid-induced osteonecrosis of the femoral head
... After transfection, media was replaced with adipogenic differentiation medium (Jiangsu Punuosheng Biotechnology Co., Ltd., lot No. C-28011) for inducing adipogenic differentia- tion, and ATRA, miR-NC, or siRNA-miR-140-5p ...
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Case Report Late isolated extramedullary relapse of acute promyelocytic leukemia present as chronic otitis media: case report and literature review
... of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) have improved the clinical outcome of refrac- tory or relapsed and newly diagnosed APL as well ...
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The retinoic acid receptor-α modulators ATRA and Ro415253 reciprocally regulate human IL-5+ Th2 cell proliferation and cytokine expression
... RA: Retinoic acid; ATRA: All-trans retinoic acid; RAR α : Retinoic acid receptor alpha; RXR: Retinoid X receptor; PBMC: Peripheral blood mononuclear cells; HDM: ...
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