all-trans retinoid acid
Treatment of non high risk acute promyelocytic leukemia with realgar indigo naturalis formula (RIF) and all trans retinoid acid (ATRA): study protocol for a randomized controlled trial
... retinoic acid receptor alpha (RARα) and promyelo- cytic leukemia (PML) ...of all-trans retinoid acid (ATRA) APL was a highly fatal disease be- cause of potentially severe coagulopathy ...
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Anti-tumour effects of all-trans retinoid acid on serous ovarian cancer
... (ε-aminocaproic acid; ε-ACA, 100 mM, Sigma Aldrich) prior to the addition of the plas- min substrate, chromozyme PL (3 mM in 100 mM gly- cine, Roche Diagnostics, Mannhein, ...
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Inhibition of mitotic kinase Aurora suppresses Akt 1 activation and induces apoptotic cell death in all trans retinoid acid resistant acute promyelocytic leukemia cells
... Here we showed that Aurora kinase small-molecule inhibitor VX-680 led to mitotic defects in spindle and decreased expression of phosphorylated Aur-A at the activation site, Thr288 in APL[r] ...
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The retinoic acid receptor-α modulators ATRA and Ro415253 reciprocally regulate human IL-5+ Th2 cell proliferation and cytokine expression
... Retinoic acid; ATRA: All-trans retinoic acid; RAR α : Retinoic acid receptor alpha; RXR: Retinoid X receptor; PBMC: Peripheral blood mononuclear cells; HDM: House dust mite; Ag: ...
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Retinoic acid inhibits the regulated expression of vascular cell adhesion molecule 1 by cultured dermal microvascular endothelial cells
... Retinoic acid and synthetic deriva- tives have been demonstrated to exert antiinflammatory ef- fects in cutaneous ...of retinoid action in the modulation of inflammatory responses, we ex- plored effects of ...
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CRABP-II- and FABP5-independent responsiveness of human glioblastoma cells to all-trans retinoic acid
... RA can signal via two classical pathways, mediated by CRABP-II or FABP5, which result in distinct cellular responses [15]. CRABP-II delivers RA from the cytosol to nuclear retinoic acid receptors (RARs), which ...
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Potential for combined delivery of riboflavin and all trans retinoic acid, from silk fibroin for corneal bioengineering
... Retinoic acid induces corneal stromal regeneration markers through both nuclear receptors mediated and nonnuclear receptor mediated ...the retinoid-con- trolled ...
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Effect of L-Ascorbic Acid and All-trans Retinoic Acid on Smooth Muscle Cells Cultured on PCL Scaffolds
... The current understanding of the effect of atRA on vSMC phenotype is that an anti- proliferative and differentiated state is induced. Interestingly, atRA is being investigated for its role is preventing intimal ...
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THE EFFECT OF ALL-TRANS RETINOIC ACID AND FATTY ACIDS ON MCF-7 BREAST CANCER CELL PROGRESSION
... Acyclo-retinoic acid was investigated for its possible role in activating the retinoic acid response element and slowing proliferation of immortal human mammary carcinoma cells (MCF-7) cells in ...This ...
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All-trans retinoic acid can antagonize osteoblastogenesis induced by different BMPs irrespective of their dimerization types and dose-efficiencies
... do not adequately explain the phenomena observed in the previous studies. It is important to note that a large number of the studies used ALP activity and gene expression as markers for osteogenic differentiation. ...
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Original Article The effect of all trans retinoid nanostructured lipid carriers on cytokines and chemokines releasing induced by zymosan
... Emulsification process from scratch method was used to prepare the ATRA-NLC. Oil phase: weight 1.5 mg, whales wax palm 150 mg, 3.6 mg, lecithin BHT 0.1 mg, oleic acid 37.5 mg, and 112.5 mg soybean oil accurately, ...
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Human skin levels of retinoic acid and cytochrome P 450 derived 4 hydroxyretinoic acid after topical application of retinoic acid in vivo compared to concentrations required to stimulate retinoic acid receptor mediated transcription in vitro
... retinoic acid receptors (RARs) or retinoid X receptor-alpha (RXR-alpha) and a chloramphenicol acetyl transferase (CAT) reporter plasmid containing a retinoic acid responsive element into CV-1 cells ...
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Analysis of the role of thrombomodulin in all-trans retinoic acid treatment of coagulation disorders in cancer patients
... All-trans retinoic acid (RA) plays key roles in cancer treat- ment and prevention. Breast, lung, bladder, prostate, and acute promyelocytic leukemia (APL) cancers were shown to be suppressed by RA ...
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Retinoids in the treatment of glioma: a new perspective
... acid receptor agonist, Am80 (tamibarotene), currently in clinical use for the treatment of acute promyelocytic leu- kemia, was effective in treating intracerebral hemorrhage, which accompanies inflammatory ...
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The combination of valproic acid, all-trans retinoic acid and low-dose cytarabine as disease-stabilizing treatment in acute myeloid leukemia
... valproic acid and theophylline on peripheral blood blast counts for a subset of AML patients ...valproic acid [8-14], and for this reason we used only these two drugs in our present study and theophylline ...
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Maintenance therapy with all-trans retinoic acid and arsenic trioxide improves relapse-free survival in adults with low- to intermediate-risk acute promyelocytic leukemia who have achieved complete remission after consolidation therapy
... chemotherapy. Myelosuppression was observed significantly less frequently in patients administered maintenance therapy with ATRA and As 2 O 3 than in those administered chemo- therapy. The commonly observed adverse ...
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The molecular biology of acute promyelocytic leukaemia and its response to therapy
... of retinoid signalling pathways (Wang et a l, ...retinoic acid dependent transactivation of the cyclin-dependent kinase inhibitor gene, which regulates cell cycle progression and is involved in the control ...
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Fungistatic activity of all-trans retinoic acid against <em>Aspergillus fumigatus</em> and <em>Candida albicans</em>
... of all-trans retinoic acid (ATRA) is mainly related to its strong capacity to stimulate monocyte-mediated immunity, but no consideration was given to its potential direct fungistatic ...
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All trans retinoic acid stimulates synthesis of cyclic ADP ribose in renal LLC PK1 cells
... Cyclic adenosine diphospho-ribose (cADPR) triggers Ca2+ release from intracellular stores and is therefore proposed to function as a second messenger in cellular signaling; however, an extracellular stimulus, i.e., first ...
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Characterisation of chicken RXR-γ
... Despite this mounting evidence in favour of the idea that RA is the PR morphogen, it was also found that there were differences between the behaviour of PR grafts and RA. Noji et al (1991) found that implantation of a ...
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