Alternative-splicing events
Determining the impact of alternative splicing events on transcriptome dynamics
... tional inhibition exists. Further work will be required to confirm the hypothesis of such a feedback mechanism. In summary, we report here a protocol that enables the measurement of the impact of endogenous ...
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Operative sequentiality in tumor differentiation and progression as protein molecular structure and sequence context in modulating alternative splicing events
... Pre-mRNA splicing incorporates both constitutive and alternative modes of generation of a wide variety of pro- teins within the context of a variety of disorders includ- ing in particular developmental ...
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Prognostic role of alternative splicing events in head and neck squamous cell carcinoma
... splice events across 33 tumors based on TCGA RNA-seq data. To quantify AS events, the percent spliced in (PSI) value was processed for further data ...in splicing events. AS events with ...
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Pharmacology of modulators of alternative splicing
... genome-wide alternative splicing events in ...of splicing factors from the RNA polymerase and formation of RNA/DNA hybrids between the pre-mRNA and the uncoiled DNA known as R-loops (Aguilera ...
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Alternative Splicing in Apicomplexan Parasites
... of splicing are often of major concern (see reference 45 for a review of available ...of alternative splicing ...of alternative splicing through failure to detect rarer ...with ...
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Meininger, Isabel (2017): Alternative splicing of MALT1 controls signaling and activation of CD4+ T cells. Dissertation, LMU München: Fakultät für Biologie
... activate alternative MALT1 ...undergo alternative splicing in response to TCR stimulation, but the underlying signaling pathways mediating exon inclusion or skipping are unknown (Magistrelli et ...
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Identification of TCERG1 as a new genetic modulator of TDP-43 production in Drosophila
... in alternative splicing events and/or differential usage of polyadenylation sites, performing 3’ Rapid Amplification of cDNA Ends (RACE) ...to alternative transcripts of different sizes ...
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Interplay Between Signaling and Splicing During T Cell Activation: A Study on Mkk7
... that alternative splicing likely plays a major role in shaping the T cell response to ...few alternative splicing events in T cells (Hemmer et ...
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EuropePMC-PMC5069560.pdf
... 45 alternative splicing events that are responsive to Celf1 ...these events contain Celf1-CLIP tags and are enriched for GU rich motifs within the alternatively spliced regions and/or the ...
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Diversification of the muscle proteome through alternative splicing
... associated alternative splicing events in muscle differentiation [65, 66, 79, ...specific splicing factors at distinct temporal stages of muscle homeostasis, the muscle-specific knockout of ...
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A study of alternative splicing in the pig
... of alternative splicing data based on EST predictions in human and ...had alternative splicing and in mouse the frequency of alternative splicing was estimated to 33% of the ...
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Differential alternative splicing regulation among hepatocellular carcinoma with different risk factors
... of alternative splicing ...AS events in Cauca- sians and ...of alternative splice events in the three pairwise comparisons of HBV ...of alternative splice events in ...
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Innovative Algorithms and Evaluation Methods for Biological Motif Finding
... about alternative variants is used. Typically, alternative variants occurs due alternative transcriptional events and alternative splicing events [55] ...Transcriptional ...
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Genomics-Based Studies Identify Cis And Trans Acting Post-Transcriptional Regulators
... IR events are also significantly (p value < ...IR events the increased structure in specific regions likely limits the accessibility of binding sites to specific RBPs allowing for a tighter control over ...
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The Alternative Splicing Mutation Database: a hub for investigations of alternative splicing using mutational evidence
... observed alternative splicing events for a gene or exon of interest, a researcher using ASMD can expect to find a curated list of small mutations that are correlated with alternative ...
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Tau exon 10 alternative splicing and tauopathies
... Alternative splicing of pre-mRNA, the differential inclu- sion or exclusion of portions of a nascent transcript into the final protein-coding mRNA, is widely recognized to be a ubiquitous mechanism for ...
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Classification of glioma based on prognostic alternative splicing
... IDH status is considered to be the primary factor in most clustering studies [2], while a recent study revealed a link between IDH status and splicing events [9]. Consist- ent with this finding, our data ...
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Linking Endoplasmic Reticular Stress and Alternative Splicing
... Xbp1 splicing, there are large-scale changes in mRNA; inhibition of the mRNA degradation function of Ire1 both reduces the number and changes the type of genes involved in altered splicing patterns, ...
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Genetic and molecular characterization of the Rev protein of equine infectious anemia virus
... BINDING OF EQUINE INFECTIOUS ANEMIA VIRUS REV TO AN EXON SPLICING ENHANCER MEDIATES ALTERNATIVE SPLICING AND NUCLEAR EXPORT OF VIRAL mRNA Abstract Introduction Materials and Methods... R[r] ...
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R and Bioconductor solutions for alternative splicing detection
... significantly as the differential expression of the respective gene increases. This caused an overesti- mation of AS for the dataset. The authors devel- oped an algorithm, COrrected Splicing Indices for Exon array ...
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