Amino Acid Substitution
Evidence That the Origin of Naked Kernels During Maize Domestication Was Caused by a Single Amino Acid Substitution in tga1
... to-Asn6 substitution using protoplast transient assays (Tiwari et ...single amino acid substitution alters the function of the TGA1 pro- ...Lys6-to-Asn6 substitution gives the ...
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Evaluating the efficacy of a structure-derived amino acid substitution matrix in detecting protein homologs by BLAST and PSI-BLAST
... blOSUM62 substitution matrix was chosen as a benchmark for two ...of amino acid substitution matrices, the blOSUM matrices have faired well against sequence- and structure-based ...
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Adaptive evolution of fish hatching enzyme: one amino acid substitution results in differential salt dependency of the enzyme
... Naruse, 1996), although adult fish are occasionally found in brackish water (Miyamoto et al., 1986). The death rate of medaka embryos in brackish water and seawater is higher than that in freshwater (Inoue and Takei, ...
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A Single-Amino-Acid Substitution in the P2 Domain of VP1 of Murine Norovirus Is Sufficient for Escape from Antibody Neutralization
... single- amino-acid change in the P2 domain that was associated with resistance to ...VP1 amino acids defined here on the NV VP1 structure based on sequence alignments predicted a close spatial ...
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Murine Coronavirus Evolution In Vivo: Functional Compensation of a Detrimental Amino Acid Substitution in the Receptor Binding Domain of the Spike Glycoprotein
... H716D substitution is necessary and sufficient to induce high viral loads in the liver and severe ...of amino acid substitutions except when paired with Q159L, as occurred in the original C12 ...
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A Single Amino Acid Substitution in the Capsid of Foot-and-Mouth Disease Virus Can Increase Acid Resistance
... Amino acid substitution VP1 N17D confers increased resis- tance to acid-induced inactivation of ...whether amino acid replacement VP1 N17D is sufficient to confer re- sistance to ...
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Analyses of Single-Amino-Acid Substitution Mutants of Adenovirus Type 5 E1B-55K Protein
... single-amino- acid substitution mutations of the adenovirus E1B-55K protein in an effort to separate the p53 binding and inactivation func- tion and late functions of this ...
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A Single Amino Acid Substitution at Residue 218 of Hemagglutinin Improves the Growth of Influenza A(H7N9) Candidate Vaccine Viruses
... G218E substitution in HA was correlated with increased NA- mediated dissociation of the HA from the receptor ...G218E substitution in HA possibly reduced the binding stability of the HA-receptor complexes, ...
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Infection of Human Dendritic Cells by a Sindbis Virus Replicon Vector Is Determined by a Single Amino Acid Substitution in the E2 Glycoprotein
... The ability to target antigen-presenting cells with vectors encoding desired antigens holds the promise of potent prophylactic and therapeutic vaccines for infectious diseases and cancer. Toward this goal, we derived ...
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A Single Amino Acid Substitution in the Capsid of Foot-and-Mouth Disease Virus Can Increase Acid Lability and Confer Resistance to Acid-Dependent Uncoating Inhibition
... between acid lability and capsid stability required for completion of virus replication allows FMDV, which disassembles at a pH close to neutrality, to escape inhibition by drugs raising the endosomal ...increased ...
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A Single Amino Acid Substitution in HIV-1 Reverse Transcriptase Significantly Reduces Virion Release
... alanine substitution at W401 (W401A) or at both W401 and W402 (W401A/ W402A) partially or almost completely negates the enhancement effect of efavirenz (a nonnucleoside reverse transcriptase inhibitor) on ...
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A single amino acid substitution of the human immunodeficiency virus type 1 capsid protein affects viral sensitivity to TRIM5α
... G-to-E substitution at the 116th position did not affect the association between CA and CypA or Gag processing To clarify whether the 116th amino acid substitution affects the association of ...
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A Single Amino Acid Substitution in the Novel H7N9 Influenza A Virus NS1 Protein Increases CPSF30 Binding and Virulence
... I106M substitution in H7N9 NS1 restores both CPSF30 binding and the inhibition of cellular gene ...I106M substitution specifically enhanced CPSF30 binding, as no differences were observed between NS1-WT and ...
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A Single Amino Acid Substitution in the NS2A Protein of Japanese Encephalitis Virus Affects Virus Propagation In Vitro but Not In Vivo
... this substitution did not affect viral loads in the brain or survival curves in ...other amino acid and/or nucleotide substitutions may affect host responses, such as antiviral ...
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An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance
... The intestinal fatty acid binding protein locus (FABP2) was investigated as a possible genetic factor in determining insulin action in the Pima Indian population. A polymorphism at codon 54 of FABP2 was identified ...
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Biologically inactive growth hormone caused by an amino acid substitution
... single-base substitution (A → G) in exon 4 of the GH-1 gene of a girl with short stature, clinically suspected to indicate the presence of bioinactive GH and resulting in the substitution of glycine for ...
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A Single Amino Acid Substitution in Obg Activates a New Programmed Cell Death Pathway in Escherichia coli
... ObgE*-mediated PCD is distinct from previously described bacterial cell death mechanisms. To unravel the mechanism underlying ObgE*-mediated PCD, we investigated the involve- ment of key regulators of previously ...
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Effects of a naturally occurring amino acid substitution in bovine PrP: a model for inherited prion disease in a natural host species
... glutamic acid to lysine substitution at position 200 (E200K) in the prion pro- ...E211K substitution was associated with a case of bovine spongiform encephalopathy from ...
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Point mutation causing a single amino acid substitution in the hormone binding domain of the glucocorticoid receptor in familial glucocorticoid resistance
... In order to determine whether the identified base substitution is responsible for glucocorticoid resistance in this kindred, T was inserted in place of A at position 2054 of the normal h[r] ...
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A single amino acid substitution in a hydrophobic domain causes temperature-sensitive cell-surface transport of a mutant viral glycoprotein.
... 374 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest DNA sequences were determined for three cDNA clones encoding vesicular stomatitis virus glycoproteins from the ts045[r] ...
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