AML blasts
Phospho-MEK1/2 and uPAR Expression Determine Sensitivity of AML Blasts to a Urokinase-Activated Anthrax Lethal Toxin (PrAgU2/LF)
... primary AML blasts using PrAgU2/LF, a urokinase-activated anthrax lethal ...nine AML cell ...primary blasts from AML patients, with blasts from four out of five patients showing ...
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peptide induces a caspase-independent, Ca 2+ -dependent death in human leukemic myeloid cells by targeting surface aminopeptidase N/CD13
... that AML cell lines express the 88 kDa progranulin; the level of progranulin protein was downregulated in NGR-peptide-1 treated cells, and this decrease was blocked by BAPTA and ...of AML blast resistance ...
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Arginine dependence of acute myeloid leukaemia blast proliferation: a novel therapeutic target
... patients’ blasts are deficient in either ASS or OTC enzymes, strongly suggesting that AML blasts are reliant on extracellular arginine ...support AML expansion is unknown, but analogous ...
52
Aberrant splicing and drug resistance in AML
... chemoresistant AML cell lines [85]. Intri- guingly, one study performed with AML blasts from patients with relapsed chemoresistant AML, found the p75 splice variant of the lens ...
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Inhibition of Bcl-xL overcomes polyploidy resistance and leads to apoptotic cell death in acute myeloid leukemia cells
... in AML cell lines and primary AML ...in AML, and that suppression of Bcl-xL by ABT-263, or siRNAs, may hold therapeutic utility in drug-resistant polyploid AML ...
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CD56bright NK cells exhibit potent antitumor responses following IL 15 priming
... primary AML blasts for 4–5 hours and assaying of 7-AAD uptake as previously described ...or AML blast death (no effector control wells) was subtracted to yield percentage specific kill- ing, and in ...
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Differential expression and biochemical activity of the immune receptor Tim-3 in healthy and malignant human myeloid cells
... human AML blasts and healthy primary human leukocytes obtained from peripheral blood (buffy ...primary AML cells, Tim-3 expression is much higher compared to primary healthy ...primary AML ...
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Acid ceramidase is upregulated in AML and represents a novel therapeutic target
... in AML. Mcl-1 has been shown to prolong blast survival in AML mouse models and is highly expressed in AML blasts [25, ...of AML patient cells and cell lines ...affects AML ...
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Gene and protein analysis reveals that p53 pathway is functionally inactivated in cytogenetically normal Acute Myeloid Leukemia and Acute Promyelocytic Leukemia
... in AML blasts [99, 100, 102–110] should activate the p53 ...APL blasts as we did not find induction of genes related to various p53- functional outcomes, cell cycle arrest, apoptosis, DNA repair and ...
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Suppression of APC/C Cdh1 has subtype specific biological effects in acute myeloid leukemia
... (AML) blasts compared to normal CD34+ ...an AML subtype which is highly vulnerable to differentiation therapy with all-trans retinoic acid ...in AML biology by contributing to the ...
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United Nations Watchdog Blasts US for Persistent Racism
... This Editorial is brought to you for free and open access by the Faculty Publications at Digital Commons @ Western New England University School of Law.. It has been accepted for inclusi[r] ...
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<p>Molecular Targeting and Rational Chemotherapy in Acute Myeloid Leukemia</p>
... naïve AML and MDS patients produced an ORR of 31% for AML and 50% for ...diagnosed AML (Table ...13 AML patients with relapsed/refractory disease treated concurrently attained complete ...
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Routine use of microarray-based gene expression profiling to identify patients with low cytogenetic risk acute myeloid leukemia: accurate results can be obtained even with suboptimal samples
... sub-optimal AML samples with poor quality control criteria, mainly because of low amounts of hybridized cRNAs, were all correctly classified, even though half of these contained less than 60 percent blasts ...
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Infections in children with down syndrome and acute myeloid leukemia: a report from the Canadian infections in AML research group
... undergoing AML therapy is surprising. More than 60% of non-DS children with AML treated according to the CCG 2961 protocol experienced an infection during each course of chemotherapy ...pediatric AML ...
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The Challenges of Managing Bomb Blasts Victims in Nigeria
... Crime can be displaced due to crime hardening by law enforcement agencies. Crime displacement is a change of offenders behaviour along illegitimate means which is designed to circumvent either specific preventing ...
5
Overexpression of lncRNA <em>PANDAR </em>predicts adverse prognosis in acute myeloid leukemia
... in AML patients who achieved CR and those without CR, and showed it in scatter plots (P< ...whole-cohort AML and non-M3 AML patients (P= ...
9
Original Article HOTTIP is upregulated in acute myeloid leukemia that indicates a poor prognosis
... novo AML patients, AML-CR (complete remission) patients and normal controls by real-time quantitative reverse transcription-PCR (qRT-PCR), and then we analyzed the relationship between the HOTTIP expression ...
5
Expression of Transcription Factor AML-2 (RUNX3, CBFα-3) Is Induced by Epstein-Barr Virus EBNA-2 and Correlates with the B-Cell Activation Phenotype
... The other genes investigated included those encoding a cy- tokine (IL-16), a transcription factor (RUNX3), components of cell signaling pathways (pleckstrin, PI3KR1 p85␣, and PTK 2B), and a gene involved in the stress ...
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miR-134 increases the antitumor effects of cytarabine by targeting Mnks in acute myeloid leukemia cells
... relapsed/refractory AML patient ...refractory AML patient ...in AML Ara-C resistance through increasing cell sensitivity to Ara-C and promoting apoptosis by targeting ...
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Diagnosis and Classification of Acute Leukemia in Bone Marrow Trephine Biopsies, Utility of a Selected Panel of Minimal Immunohistochemical Markers
... detect blasts of myeloid lineage by the 3 major conglomerates in hematology namely European Group for the Immunological Characterization of Leukemias (EGIL), US–Canadian Consensus Group (USCC) and British ...
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