amyloid-β peptide
apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain
... Neurotoxic amyloid β peptide (Aβ) accumulates in the brains of individuals with Alzheimer disease (AD). The APOE4 allele is a major risk factor for sporadic AD and has been associated with increased ...
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Transgenic Rice Expressing Amyloid β-peptide for Oral Immunization
... The onset of AD is thought to be due to amyloid β-peptide (Aβ) deposition in the cerebral cortex [1,2]. As Aβ is a protein, vaccines for AD are potential means of therapy or prevention [3-5]. In ...
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Monoamine oxidase B is elevated in Alzheimer disease neurons, is associated with γ-secretase and regulates neuronal amyloid β-peptide levels
... APP: Amyloid precursor protein; A β : Amyloid β -peptide; co-IP: Coimmunoprecipitation; CTCF: Corrected total cell fluorescence; CTF: C-terminal fragment; DIV: Days in vitro; ER: ...
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Different aspects of Alzheimer’s disease-related amyloid β-peptide pathology and their relationship to amyloid positron emission tomography imaging and dementia
... of amyloid β-peptide (Aβ) in amyloid plaques is one of the histopathological hallmark lesions of Alzheimer’s disease (AD) [47] together with neurofib- rillary tangles (NFTs) ...in ...
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Increased amyloid β-peptide uptake in skeletal muscle is induced by hyposialylation and may account for apoptosis in GNE myopathy
... GNE myopathy is an autosomal recessive muscular disorder of young adults characterized by progressive skeletal muscle weakness and wasting. It is caused by a mutation in the UDP-N-acetylglucosamine ...
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Amyloid-β peptide-induced extracellular S100A9 depletion is associated with decrease of antimicrobial peptide activity in human THP-1 monocytes
... Synthetic siRNA for S100A9 and the non-specific con- trol pool were purchased from Santa Cruz Biotechnol- ogy (Santa Cruz, CA, USA). Lipofectamine 2000 was purchased from Invitrogen (Carlsbad, CA, USA). Anti- S100A9 was ...
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Amyloid β peptide-mediated neurotoxicity is attenuated by the proliferating microglia more potently than by the quiescent phenotype
... Mouse monoclonal antibody to GFAP and Hoechst 33258 were purchased from Invitrogen (Carlsbad, CA, USA). An enhanced chemiluminescence detection re- agent and anti-rabbit IgG antibody conjugated with horseradish ...
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The type of Aβ-related neuronal degeneration differs between amyloid precursor protein (APP23) and amyloid β-peptide (APP48) transgenic mice
... A β aggregates were found in both transgenic mouse lines. The A β detected in the insoluble fraction of the forebrain homogenates of APP48 mice represents A β aggregates that require formic acid ...
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Modeling of platinum aryl interaction with amyloid β peptide
... inhibit Aβ aggregation, and inhibit its neurotoxicity in vitro. Additionally, Pt(II) compounds are stable (i.e. kinetically and redox inert) in biological systems, meaning that once the Pt(II) complex is bound to a ...
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Bilirubin and Amyloid-β Peptide Induce Cytochrome c Release Through Mitochondrial Membrane Permeabilization
... A peptide on these organelles, we assayed the membrane permeability in mitochondria isolated from adult ...A peptide on the mitochondrial membrane permeability was examined and is also shown in Figure ...A ...
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Induction of serine racemase expression and D-serine release from microglia by amyloid β-peptide
... A role for excitotoxicity in CNS inflammation is becoming well established. One of the first analyses of the relative roles of various neurotoxins released by activated micro- glia found that NMDA receptor antagonists ...
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Neurotrophic Factors Regulate Cathepsin S in Macrophages and Microglia: A Role in the Degradation of Myelin Basic Protein and Amyloid β Peptide
... compared to control cells (Fig. 5A), which is consistent with the relative decrease in cathepsin S mRNA after 48 hr (data not shown). Therefore, cellular cathepsin S activity in macropha[r] ...
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The CCAAT/enhancer binding protein (C/EBP) δ is differently regulated by fibrillar and oligomeric forms of the Alzheimer amyloid-β peptide
... IL-1b, as well as other inflammatory stimuli, has been shown to activate the Ras pathway [47]. The Ras path- way in turn can result in both extracellular signal-regu- lated kinase (ERK) 1/2 and IKKi activation [48]. A ...
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In Silico Analysis of the Apolipoprotein E and the Amyloid β Peptide Interaction: Stabilizing a Molten Globule by Frustration of the Salt Bridges Network
... Ab peptide and occurring in helices I and II of ApoE4 (but not ApoE3) would soon be transmitted to helix III stabilizing the Arg61-Glu66 and breaking the Arg61-Glu109 salt bridges in this N-terminal domain, and ...
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TRPA1 channels promote astrocytic Ca2+ hyperactivity and synaptic dysfunction mediated by oligomeric forms of amyloid-β peptide
... toxic amyloid-β (Aβ) species and their accumulation in plaques are key hallmarks in the patho- genesis of Alzheimer’s disease (AD) but it has now been recognized that, far ahead of plaques formation, ...
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Distinct cerebrospinal fluid amyloid β peptide signatures in sporadic and PSEN1A431E-associated familial Alzheimer's disease
... higher than normal Ca 2+ and Mg 2+ concentrations were used to inhibit spontaneous network activity. ACSF was spiked with synthetic Ab1-16 (Bachem, Weil am Rhein, Germany) in water solution to a final concentration of 1 ...
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A direct interaction between mitochondrial proteins and amyloid β peptide and its significance for the development and treatment of Alzheimer’s disease
... extracellular amyloid-β (Aβ) deposits also called senile plaques, intracellular deposits of phosphorylated tau-protein called neurofibrillary tangles and diffuse loss of neurons [2, ...
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The anti-inflammatory Annexin A1 induces the clearance and degradation of the amyloid-β peptide
... major amyloid-degrading enzyme [39] and is mainly located on neuronal cells, especially in the stria- tonigral pathway [40, ...A β degradation by alternative mechanisms that do not involve FPRL1/FPR2 ...
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Cu(II) enhances the effect of Alzheimer’s amyloid-β peptide on microglial activation
... A β confers different chemical properties on the resulting ...Cu(II)-A β (but not A β or Cu(II) alone) treatment induced an activating morphological phenotype of microglia and induced the microglial ...
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Soluble aggregates of the amyloid-β peptide are trapped by serum albumin to enhance amyloid-β activation of endothelial cells
... the amyloid hypothesis implicate a principal role for soluble A aggregates, including A- derived diffusible ligands (ADDLs), oligomers, and pro- tofibrils, in the pathogenesis of ...
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