Amyotrophic lateral sclerosis 8
A blended psychosocial support program for partners of patients with amyotrophic lateral sclerosis and progressive muscular atrophy: protocol of a randomized controlled trial
... Methods: This study is a randomized controlled trial using a wait-list control design. One hundred and forty caregiver-patient dyads, recruited from a nationwide database and through the website of the Dutch ALS Center, ...
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Amyotrophic lateral sclerosis
... The World Federation of Neurology (WFN) Research Group on Motor Neuron Diseases have developed the 1994 'El Escorial' diagnostic criteria [8] and the revised 2000 'Airlie House' criteria [9] to aid in diagnosing ...
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The Genetics of Amyotrophic Lateral Sclerosis: Current Insights
... The multiple mutations throughout the protein have also resulted in challenges determining how they are responsible for the disease phenotype. SOD1 is a ubiquitously expressed antioxidant protein, which catalyses free ...
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Mitochondrial dynamic abnormalities in amyotrophic lateral sclerosis
... Mitochondria are double membrane-bound organelles that are involved in multiple major cellular processes in- cluding ATP production, metabolite synthesis, calcium homeostasis, reactive oxygen species generation and even ...
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Amyotrophic Lateral Sclerosis and Multiple Sclerosis Overlap: A Case Report
... Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder, characterized by progressive weakness of limb, bulbar, and respiratory muscles, with an annual incidence in Europe of ...Multiple ...
5
Respiratory measures in amyotrophic lateral sclerosis
... Some respiratory tests have been shown to predict survival in ALS (1,60,63–70). For example, a single FVC value obtained at an initial visit was shown to serve as a clinically meaningful predictor of survival (1,65), and ...
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Interneuron dysfunction in amyotrophic lateral sclerosis
... from 8 weeks in the supragranular lamina of the motor cortex, progress to loss of CR-expressing neurons by 16 weeks, and include contrasting alterations of CR and NPY populations by end-stage disease at 20 ...from ...
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Therapeutic applications of mesenchymal stem cells for amyotrophic lateral sclerosis
... Multiple stem and progenitor cell types could have the potential to either directly replace MNs and diseased glia or provide support to slow degeneration. These cells include pluripotent cells such as embryonic stem (ES) ...
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Chitotriosidase - a putative biomarker for sporadic amyotrophic lateral sclerosis
... with Agilent’s 1200 series nanoflow liquid chromatog- raphy system (Agilent Technologies, Santa Clara, CA). Each sample was loaded on to the enrichment column (75 μm × 2 cm, 5 μm, 120 Å, Magic C18 AQ MichromBioresources) ...
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Astroglia acquires a toxic neuroinflammatory role in response to the cerebrospinal fluid from amyotrophic lateral sclerosis patients
... The activated astrocytes may adopt either a neuro- protective or a neurotoxic phenotype in a stimulus- dependent manner by a process termed as glial polarization; the end-results of which depend largely on the ...
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Neuropsychological study of amyotrophic lateral sclerosis and parkinsonism-dementia complex in Kii peninsula, Japan
... All patients underwent a standard cognitive status assessment. ALS/PDC clinically show amnesia and bra- dyphrenia, therefore we chose Mini Mental State Exam- ination (MMSE) [15] for global cognition, Raven’s Colored ...
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Evaluation of neuroimaging biomarkers in amyotrophic lateral sclerosis
... In spite of their underlying pathological differences, neurodegenerative condi- tions share a number of strikingly common features, such as insidious symp- tom onset, diagnostic challenges, relentless disease ...
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Analysis of riluzole’s profile of use in a Central Hospital in Lisbon
... Purpose: Riluzole is indicated to prolong life or delay the institution of mechanical ventilation in patients with amyotrophic lateral sclerosis (ALS). Clinical studies have shown that this drug ...
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Language contributions to health related quality of life in Amyotrophic Lateral Sclerosis
... Language contributions to health related quality of life in Language contributions to health related quality of life in Amyotrophic Lateral Sclerosis.. Amyotrophic Lateral Sclerosis K[r] ...
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An overview of motor unit number index reproducibility in amyotrophic lateral sclerosis
... Motor unit number index (MUNIX) is an electrophysiological technique to give an estimate of functioning motor neurons in a muscle. For any given neurophysiological technique for the use in clinical or research studies, ...
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Coronary Artery Disease in Young Indians: A Different Entity
... Primary lateral sclerosis (PLS), Flail arm syndrome (Vulpian-Bernhardt syndrome), Flail leg syndrome (Pseudopolyneuritic form) and ALS plus syndrome ...
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The Environmental Epidemiology of Amyotrophic Lateral Sclerosis in Europe
... However a 2014 systematic review and meta-analysis of 37 studies again concluded that there was Armon class A evidence that physical activity was not a risk factor for ALS, but for occup[r] ...
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AMYOTROPHIC LATERAL SCLEROSIS A PROGRESSIVE MUSCLE WEAKNESS
... Amyotrophic lateral sclerosis (ALS) is a nervous system disease that attacks nerve cells called neurons in your brain and spinal cord. The neurons transmit messages from your brain and spinal cord to ...
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Programmed cell death in amyotrophic lateral sclerosis
... Amyotrophic lateral sclerosis (ALS) is a relentless fatal paralytic disorder confined to the voluntary motor system (1). Its prevalence is about three to five in 100,000 individuals, making it the ...
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Topography of FUS pathology distinguishes late-onset BIBD from aFTLD-U
... AD: Alzheimer ’ s disease; aFTLD-U: Atypical frontotemporal lobar degeneration with ubiquitin-positive inclusions; ALS: Amyotrophic lateral sclerosis; ALS-FUS: Amyotrophic lateral sclero[r] ...
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