Andes virus
The Andes Virus Nucleocapsid Protein Directs Basal Endothelial Cell Permeability by Activating RhoA
... ABSTRACT Andes virus (ANDV) predominantly infects microvascular endothelial cells (MECs) and nonlytically causes an acute pulmonary edema termed hantavirus pulmonary syndrome ...Hantaan ...
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Andes Virus Infection of Lymphatic Endothelial Cells Causes Giant Cell and Enhanced Permeability Responses That Are Rapamycin and Vascular Endothelial Growth Factor C Sensitive
... H antaviruses predominantly infect endothelial cells (ECs) which line vessels and nonlytically cause 2 vascular diseases: hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS) (48, 51, 59, ...
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An Innate Immunity Regulating Virulence Determinant Is Uniquely Encoded within the Andes Virus Nucleocapsid Protein
... Plasmids. Plasmids expressing N proteins from New York-1 virus (U36802.1), Andes virus (ANDV) (CHI-7913; AY228237.1), Sin Nombre virus (SNV) (JQ690276.1), and Prospect Hill virus (PHV) ...
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Immune Serum Produced by DNA Vaccination Protects Hamsters against Lethal Respiratory Challenge with Andes Virus
... Hantavirus pulmonary syndrome (HPS) is a highly pathogenic disease (40% case fatality rate) carried by rodents chronically infected with certain viruses within the genus Hantavirus of the family Bunyaviridae. The primary ...
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Unique Interferon Pathway Regulation by the Andes Virus Nucleocapsid Protein Is Conferred by Phosphorylation of Serine 386
... ABSTRACT Andes virus (ANDV) causes hantavirus pulmonary syndrome (HPS) and is the only hantavirus shown to spread person to person and cause a highly lethal HPS-like disease in Syrian ...Maporal ...
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Temporal Analysis of Andes Virus and Sin Nombre Virus Infections of Syrian Hamsters
... Andes virus (ANDV) and Sin Nombre virus (SNV) are rodent-borne hantaviruses that cause a highly lethal hemorrhagic fever in humans known as hantavirus pulmonary syndrome ...infectious virus in ...
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Phage Display Selection of Cyclic Peptides That Inhibit Andes Virus Infection
... Andes virus (ANDV), an NIAID category A agent linked to hantavirus cardiopulmonary syndrome (HCPS), belongs to the family Bunyaviridae and the genus Hantavirus and is carried by Oligoryzomys longicaudatus ...
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Adenovirus Vectors Expressing Hantavirus Proteins Protect Hamsters against Lethal Challenge with Andes Virus
... Nombre virus (SNV) and Andes virus (ANDV) cause the most frequently recognized and se- vere cases of human disease in North and South America, respectively (11, ...
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Ecology, Genetic Diversity, and Phylogeographic Structure of Andes Virus in Humans and Rodents in Chile
... Andes virus (ANDV) is the predominant etiologic agent of hantavirus cardiopulmonary syndrome (HCPS) in southern South ...the virus is under- going purifying selection and demonstrated a recent ...
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The N Terminus of Andes Virus L Protein Suppresses mRNA and Protein Expression in Mammalian Cells
... Little is known about the structure and function of the 250-kDa L protein of hantaviruses, although it plays a central role in virus genome transcription and replication. When attempting to study Andes ...
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Andes Virus Regulation of Cellular MicroRNAs Contributes to Hantavirus-Induced Endothelial Cell Permeability
... (Sigma). Andes virus (CHI-7913; ANDV) (45) was kindly provided by ...Tula virus (TULV; Tula/Moravia/MA5302V/94) (20) were cultivated as previously de- scribed (20) in a biosafety level 3 facility and ...
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VEGFR2 and Src Kinase Inhibitors Suppress Andes Virus-Induced Endothelial Cell Permeability
... Hantaviruses predominantly infect human endothelial cells and, in the absence of cell lysis, cause two diseases resulting from increased vascular permeability. Andes virus (ANDV) causes a highly lethal ...
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Pathogenic Hantaviruses Andes Virus and Hantaan Virus Induce Adherens Junction Disassembly by Directing Vascular Endothelial Cadherin Internalization in Human Endothelial Cells
... Hantaviruses infect endothelial cells and cause 2 vascular permeability-based diseases. Pathogenic hanta- viruses enhance the permeability of endothelial cells in response to vascular endothelial growth factor (VEGF). ...
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Andes Virus Disrupts the Endothelial Cell Barrier by Induction of Vascular Endothelial Growth Factor and Downregulation of VE-Cadherin
... Hantaviruses, of the family Bunyaviridae, are rodent-borne RNA viruses. Members of the Hantavirus genus have been identified as etiologic agents of two severe human diseases: hemorrhagic fever with renal syndrome (HFRS), ...
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Hypoxia Induces Permeability and Giant Cell Responses of Andes Virus-Infected Pulmonary Endothelial Cells by Activating the mTOR-S6K Signaling Pathway
... Andes virus (ANDV) is a South American hantavirus that causes a highly lethal hantavirus pulmonary syndrome (HPS) charac- terized by hypoxia, thrombocytopenia, and vascular leakage leading to acute ...
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Andes Virus Nucleocapsid Protein Interrupts Protein Kinase R Dimerization To Counteract Host Interference in Viral Protein Synthesis
... ANDV NP selectively inhibits PKR without affecting the ac- tivity of other eIF2␣ kinases. There are four eIF2␣ kinases that phosphorylate eIF2 ␣ under different stress conditions or in re- sponse to different stimuli and ...
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Host mTORC1 Signaling Regulates Andes Virus Replication
... H antaviruses (family Bunyaviridae) are negative-sense RNA vi- ruses harbored by small mammals and have worldwide dis- tribution (1–5). Despite global spread, hantavirus strains are con- fined to the geographic range of ...
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Andes Virus Recognition of Human and Syrian Hamster β3 Integrins Is Determined by an L33P Substitution in the PSI Domain
... It is unclear whether unique ANDV interactions with  3 integrins are responsible for the discrete ability of ANDV to cause disease in Syrian hamsters or permit person to person transmission. NY-1V is clearly restricted ...
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Bidirectional Virus Secretion and Nonciliated Cell Tropism following Andes Virus Infection of Primary Airway Epithelial Cell Cultures
... A virus is capable of infecting both ciliated and nonciliated cell populations de- pending on the virus strain ...by virus infection via the basolateral membrane (data not ...
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Vesicular Stomatitis Virus-Based Vaccine Protects Hamsters against Lethal Challenge with Andes Virus
... Nombre virus (SNV) N, an indirect enzyme-linked immunosorbent assay (ELISA) using SNV N recombinantly expressed in Escherichia coli as an antigen (kindly pro- vided by ...the virus and were incubated at ...
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