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angiotensin receptor type 1

Prolonged fasting activates Nrf2 in post weaned elephant seals

Prolonged fasting activates Nrf2 in post weaned elephant seals

... by angiotensin II (Ang II), in a TGF-β-independent manner, during acute stimulation (Block et ...the angiotensin receptor type 1 (AT1) increases Smad2 phosphorylation in the skeletal ...

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Altered irisin/BDNF axis parallels excessive daytime sleepiness in obstructive sleep apnea patients

Altered irisin/BDNF axis parallels excessive daytime sleepiness in obstructive sleep apnea patients

... ACE: Angiotensin converting enzyme; AHI: Apnea-hypopnea index; apoA1: Apolipoprotein A1; apoB: Apolipoprotein B; ARB: Angiotensin receptor (type 1) blocker; BDNF: Brain-derived ...

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Molecular modeling of angiotensin type 1 receptor for angiotensin receptor blockers

Molecular modeling of angiotensin type 1 receptor for angiotensin receptor blockers

... (AT1) receptor, belong to the family of ...of angiotensin receptor blockers ensin II binds to the AT1 receptor within the transmembrane domains in an extended conformation, and its C-terminal ...

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Role of host angiotensin II type 1 receptor in tumor angiogenesis and growth

Role of host angiotensin II type 1 receptor in tumor angiogenesis and growth

... proinflammatory molecule for immune-privileged tis- sues and cells (33, 34). In fact, macrophages express AT1 receptor intensively, and ATII enhances macro- phage inflammatory functions through the AT1 ...

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Type 1 angiotensin receptors on macrophages ameliorate IL 1 receptor–mediated kidney fibrosis

Type 1 angiotensin receptors on macrophages ameliorate IL 1 receptor–mediated kidney fibrosis

... AT1 receptor activation on macrophages to mitigate kidney damage has broad implications for the design of potent therapies to overcome the shortcomings of global angiotensin receptor blockade related ...

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Evidence for the importance of angiotensin II type 1 receptor in ischemia induced angiogenesis

Evidence for the importance of angiotensin II type 1 receptor in ischemia induced angiogenesis

... AT1 receptor–dependent, but blood pressure–inde- pendent, mechanism ...AT1a receptor may have resulted in reduced inflammatory reactions, and that, conse- quently, angiogenesis was ...

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Increase of angiotensin II type 1 receptor auto-antibodies in Huntington’s disease

Increase of angiotensin II type 1 receptor auto-antibodies in Huntington’s disease

... Huntington’s disease (HD) is a devastating, progressive neurodegenerative disease with autosomal dominant in- heritance, characterized by movement disorder, cognitive decline and behavioral abnormalities. It is caused by ...

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Rho-Associated Coiled-Coil Kinase (ROCK) in Molecular Regulation of Angiogenesis

Rho-Associated Coiled-Coil Kinase (ROCK) in Molecular Regulation of Angiogenesis

... II: angiotensin II; AT1R: Ang II type 1 receptor; AT2R: Ang II type 2 receptor; CCM2: cerebral cavernous malformations 2; EC: endothelial cell; ECM: extracellular matrix; EGF: ...

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Genetic associations between genes in the renin-angiotensin-aldosterone system and renal disease: a systematic review and meta-analysis

Genetic associations between genes in the renin-angiotensin-aldosterone system and renal disease: a systematic review and meta-analysis

... with type 2 diabetes and nephropathy compared with individuals with type 2 diabetes mellitus (without nephropathy) in an East Asian population (ACE insertion compared with ...with type 2 diabetes and ...

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Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes

Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes

... duplicated angiotensin (Ang) type 1 (AT1) receptor genes, Agtr1a and ...AT2 receptor does not exert acute depressor effects in these mice lacking ...

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Effects of an Angiotensin II Type 1 Receptor Blocker on Cardiovascular Calcification

Effects of an Angiotensin II Type 1 Receptor Blocker on Cardiovascular Calcification

... subset of the Control (n = 3) and Cholesterol fed (n = 3) groups were euthanized to assess lesion progression at the time of pharmacological intervention. At twelve weeks, animals were euthanized via intravenous ketamine ...

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Effects of angiotensin converting enzyme inhibitors and angiotensin II type 1 receptor antagonists in rats with heart failure  Role of kinins and angiotensin II type 2 receptors

Effects of angiotensin converting enzyme inhibitors and angiotensin II type 1 receptor antagonists in rats with heart failure Role of kinins and angiotensin II type 2 receptors

... Histopathological study. After the hemodynamic and ventriculo- graphic studies, the rats were killed and the chest opened. The heart was excised and weighed and the LV sectioned transversely into four slices from apex to ...

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Ontogeny of type 1 angiotensin II receptor gene expression in the rat

Ontogeny of type 1 angiotensin II receptor gene expression in the rat

... the type 1 angiotensin II receptor (AT1) gene is developmentally regulated and whether the regulation is tissue specific, AT1 mRNA levels were determined by Northern blot analysis in livers ...

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Chimeric mice carrying 'regional' targeted deletion of the angiotensin type 1A receptor gene  Evidence against the role for local angiotensin in the in vivo feedback regulation of renin synthesis in juxtaglomerular cells

Chimeric mice carrying 'regional' targeted deletion of the angiotensin type 1A receptor gene Evidence against the role for local angiotensin in the in vivo feedback regulation of renin synthesis in juxtaglomerular cells

... the angiotensin type 1A (AT1A) receptor, the AT1 receptor subtype exclusively present in mouse juxta- glomerular (JG) ...↔ 1 / 1 ) is made up of wild-type ( Agtr1a ...

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CS-866, a New Angiotensin II Type 1 Receptor Antagonist, Ameliorates Glomerular Anionic Site Loss and Prevents Progression of Diabetic Nephropathy in Otsuka Long-Evans Tokushima Fatty Rats

CS-866, a New Angiotensin II Type 1 Receptor Antagonist, Ameliorates Glomerular Anionic Site Loss and Prevents Progression of Diabetic Nephropathy in Otsuka Long-Evans Tokushima Fatty Rats

... of angiotensin II in the patho- genesis of diabetic nephropathy remains to be elu- ...II type 1 receptor antagonist made it possible to differentiate the pathophysiologic prop- erties of ...

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The angiotensin II receptors type 1 blockage affects the urinary bladder activity in hyperosmolar-induced detrusor overactivity in rats: Preliminary results

The angiotensin II receptors type 1 blockage affects the urinary bladder activity in hyperosmolar-induced detrusor overactivity in rats: Preliminary results

... Telmisartan (Sigma-Aldrich, Germany), a non-peptide AT1 angiotensin II receptor antagonist, was used in the following study. Telmisartan was dissolved in DMSO and in 0.9% saline to a final concentration of  ...

5

Olmesartan for non alcoholic steatohepatitis complicated with hypertension: An open label study

Olmesartan for non alcoholic steatohepatitis complicated with hypertension: An open label study

... an angiotensin type 1 receptor blocker, in pa- tients with non-alcoholic steatohepatitis (NASH) com- plicated with ...acid, type IV collagen, and procollagen III N- terminal propeptide ...

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Angiotensin II receptor blocker telmisartan attenuates aortic stiffening and remodelling in STZ-diabetic rats

Angiotensin II receptor blocker telmisartan attenuates aortic stiffening and remodelling in STZ-diabetic rats

... either angiotensin-converting en- zyme inhibitors or Ang II type 1 receptor blockers (ARBs) has been reported to improve CV outcomes and reduce the risk of micro- and macrovascular ...

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Angiotensin type 1 receptor antagonist losartan, reduces MPTP-induced degeneration of dopaminergic neurons in substantia nigra

Angiotensin type 1 receptor antagonist losartan, reduces MPTP-induced degeneration of dopaminergic neurons in substantia nigra

... Twelve-week-old male C57BL/6 mice were euthanized using CO 2 asphyxiation. The brains were removed and immediately frozen in isopentane on dry ice. Brains were then stored at -80°C until analysis. Brains were then cut on ...

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The bradykinin BK2 receptor mediates angiotensin II receptor type 2 stimulated rat duodenal mucosal alkaline secretion

The bradykinin BK2 receptor mediates angiotensin II receptor type 2 stimulated rat duodenal mucosal alkaline secretion

... [9,18,19]. It should be noted that systemic administration of L-NAME elicits an upward shift of the basal duodenal mucosal alkaline secretion in the rat [18,20] reflecting other points of action for the compound and ...

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