anti-apoptotic
Anti-apoptotic effect of dexamethasone in an ototoxicity model
... assay. TUNEL-positive cells (green fluorescence follow- ing counterstaining with Myosin 7a) were clearly de- creased at higher doses of DEX, especially for hair cells (Fig. 3A). DEX pretreatment inhibited GM-induced ...
6
Anti-apoptotic, antioxidant and anti-aging effects of 6-shogaol on human dermal fibroblasts
... ultraviolet irradiation or oxidative stress, cytochrome c is released from the mitochondria into the cytoplasm, which in turn activates caspase 9 and caspase 3. Caspase 3 is directly activated by caspase 9 and then ...
8
Functional and structural studies of the vaccinia virus virulence factor N1 reveal a Bcl-2-like anti-apoptotic protein
... Bcl-2-like proteins that were identified through the presence of BH motifs in the primary amino acid sequence (Polster et al., 2004). Bcl-2-like proteins are encoded by gammaher- pesviruses Epstein–Barr virus (Hickish et ...
11
Pro- and anti-apoptotic CD95 signaling in T cells
... in apoptotic signaling cascades were solved by addressing consequences and pathways initiated by CD95 ligation in activated T cells or other “CD95-sensitive” cell ...in apoptotic cell ...exerts ...
9
Do plants mediate their anti diabetic effects through anti oxidant and anti apoptotic actions? an in vitro assay of 3 Indian medicinal plants
... their anti-oxidant potential which was confirmed in our study through their ability to decrease lipid peroxidation in the presence of STZ thus showing protection against the induced oxidative ...of ...
9
Pro-apoptotic versus anti-apoptotic properties of dietary resveratrol on tumoral and normal cardiac cells
... cytochrome c and Smac/Diablo present in the mitochon- drial inter-membrane space. The release of cytochrome c in the cytosol induces oligomerization of the adapter molecule Apaf-1 to generate the apoptosome complex, in ...
9
Neuroprotective effects of atorvastatin through anti oxidant, anti inflammatory and anti apoptotic mechanisms against transient ischemic/reperfusion injury in diabetic rats
... In conclusion, the current study provides the first preclinical data that demonstrates the robust neuroprotective potential of atorvastatin against neuronal injury in diabetic rats submi[r] ...
7
Antioxidant, anti-inflammatory, anti-apoptotic, and skin regenerative properties of an <em>Aloe vera</em>-based extract of <em>Nerium oleander</em> leaves (NAE-8<sup>®</sup>)
... become a subject of interest because of its beneficial effects on human health. This plant belongs to the family Liliaceae, is a perennial herb with 30–60 cm long juicy leaves, and is found growing in temperate climates ...
10
Cusack_unc_0153D_14350.pdf
... Despite the combined contributions of oxidative damage, axonal stress, and toxicity to motor neuron dysfunction in ALS, it is well established that Caspase-3 activation is the final event in the death cascade of these ...
253
Combination of Chymostatin and Aliskiren attenuates ER stress induced by lipid overload in kidney tubular cells
... To detect the level of apoptosis induced by PA in HK2 cells, we examined the expression of pro-apoptotic pro- tein Bax, anti-apoptotic protein Bcl-2, and an apoptosis effector caspase-3,[r] ...
11
Apoptotic Activities in Soft Tissue Sarcoma: Immunohistochemical Study and Their Association with Tumour Characteristics
... The two most important apoptosis regulating proteins in the development and progression of malignant tumour are the functionally antagonistic Bcl-2 and Bax. In this study, the expression of Bcl-2 was seen in 45 (44.6%) ...
7
Effects of controlled diesel exhaust exposure on apoptosis and proliferation markers in bronchial epithelium – an in vivo bronchoscopy study on asthmatics, rhinitics and healthy subjects
... Whilst none of the examined markers were altered in the asthmatics or allergic rhinitics after exposure to DE, this study is the first to report an in vivo effect of DE exposure on Bcl-2 expression in healthy subjects. ...
9
Arsenic trioxide and ascorbic acid interfere with the BCL2 family genes in patients with myelodysplastic syndromes: an ex-vivo study
... Another interesting result from the present study is the demonstration that among principal targets for ATO there are genes belonging to the BCL2 family, analo- gously to that already observed in vitro. Interestingly, ...
8
Neuroprotective Effects of Methyl 3,4-Dihydroxybenzoate Against TBHP-Induced Oxidative Damage in SH-SY5Y Cells
... endogenous apoptotic pathway in mitochondria [8]. CytC, dATP and apoptotic protease- activating factor-1 (Apaf-1) compose the apoptosome [9], which activates caspase-9 and initiates the caspase ...the ...
13
Hepatoprotective effect of Solanum surattense leaf extract against chemical induced oxidative and apoptotic injury in rats
... significant anti-fungal [13], anti-plasmodial [14], anti-hyperlipidemic [15] and anti-diabetic [16] effica- ...the anti- oxidative, anti-apoptotic and hepatoprotective ...
9
STUDY ON THE ANTI METASTATIC AND ANTICANCER ACTIVITY OF TRITERPENE COMPOUND LUPEOL IN HUMAN LUNG CANCER
... available anti-neoplastic drugs 18 ...and anti-apoptotic members like Bcl-2, Bcl-xL, Bcl-w, Mcl-1 (myeloid cell leukemia cell differentiation protein-1), and the Bcl-2-related gene A1 19 ...
7
Heat shock protein 27 downstream of P38-PI3K/Akt signaling antagonizes melatonin-induced apoptosis of SGC-7901 gastric cancer cells
... pro- apoptotic roles of melatonin, our study revealed clearly a distinguishable anti-apoptotic pathway induced by ...in apoptotic resistance in melatonin-treated SGC-7901 gastric cancer cells, ...
10
Lipoic acid decreases Mcl-1, Bcl-xL and up regulates Bim on ovarian carcinoma cells leading to cell death
... CHOP induction would result from the over production of ROS induced by the reconnection of the TCA cycle and glycolysis induced by LA. In the metabolism of cancer cells, a disconnection between glycolysis and TCA cycle ...
13
Biology-driven cancer drug development: back to the future
... *Target abbreviations: BCL-2, anti-apoptotic protein BCL-2; BCL-XL, anti-apoptotic protein BCL extra large; BCR-ABL, fusion protein of breakpoint cluster region and tyrosine kinase ABL1[r] ...
12
Original Article Propofol ameliorates ischemia/reperfusion induced cerebral injury by upregulation of microRNA-206 expression
... of apoptotic cells when propofol was administrated compared with the untreat- ed H/R group (P < ...of apoptotic cells was observed when cells were transfected with miR-206 compared with that transfected ...
9