Antigen presentation by MHC class I molecules
Expression, purification and characterization of ricin vectors used for exogenous antigen delivery into the MHC class I presentation pathway
... Disarmed versions of the cytotoxin ricin can deliver fused peptides into target cells leading to MHC class I-restricted antigen presentation [Smith et al. J Immunol 2002; 169:99- 107]. ...
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Various hypotheses on MHC evolution suggested by the concerted evolution of CD94L and MHC class Ia molecules
... do MHC class I molecules evolve faster than class II ? A general observation from comparing MHCs from differ- ent species is that the evolution of MHC class I ...
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Macrophages Escape Inhibition of Major Histocompatibility Complex Class I-Dependent Antigen Presentation by Cytomegalovirus
... The MHC I-subversive glycoproteins of MCMV control the MHC I pathway in MEF but fail to downregulate MHC I molecules in infected ...for MHC class I ...
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Presentation of intracellular antigen with MHC class II molecules
... investigated class II presentation of influenza haem agglutinin (HA) transport m utants in B ...ith class II in a chloroquine-sensitive m ...ith MHC class II, b u t in a chloroquine ...
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Studies of MHC class I antigen presentation & the origins of the immunopeptidome
... of molecules that bind antigens (protein fragments) to present to these ...continuous presentation of antigens derived from intracellular and extracellular compartments to diversified ...recognisant ...
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The systems biology of MHC class II antigen presentation
... of MHC-II Antigen Presentation Although the system of antigen presentation is understood at a high level of detail, this in fact only represents sketches of the total ...new ...
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Class I molecules of the MHC function to display peptides
... that presentation of antigen to primary T cells in vivo is fundamentally different from in vitro ...in antigen processing in the APCs used in vivo versus the var- ious tumor cells we have ...vivo ...
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Interaction of the proteins which regulate MHC class II-mediated antigen presentation by antigen presenting cells
... with MHC class II molecules, which may lead to abnormal MHC class II antigen presentation, such as premature CLIP exchange for self peptides in compartments other than ...
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The involvement of heat shock protein molecular chaperones in MHC class II antigen processing and presentation
... SDS-stable MHC class II dimers loaded with radiolabelled antigenic peptides occurs in under a minute after arrival of radiolabelled antigen into MIICs (Sanderson 1994, Fernandez- Borja ...of ...
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Melanosomes and MHC Class II Antigen-Processing Compartments
... which MHC-II molecules encounter ...with antigen pro- cessing and ...of antigen-processing compartments and (2) the presentation of melanosomal proteins as tumor-associated ...
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Whole protein and defined CD8+ and CD4+ peptides linked to penetratin targets both MHC class I and II antigen presentation pathways
... of antigen-specific CTLs which recognize endogenously generated peptides presented by cell surface class I molecules is crucial for the destruction of tumor ...of MHC class ...
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Endogenous MHC Class II Processing of a Viral Nuclear Antigen After Autophagy
... for presentation on MHC class II ...nuclear antigen 1 (EBNA1) was found to gain access to this pathway by ...cell antigen of latent Epstein-Barr virus infection, slowly accumulated in ...
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Original Article Design of a ProDer f1 vaccine delivered by the MHC class II pathway of antigen presentation and analysis of the effectiveness for specific immunotherapy
... the MHC-II processing pathway, and has been shown that truncated forms of Ii through physical interac- tion with MHC-II molecules that were fused to allergens can induce efficient antigen ...
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Antigen presentation by mouse CD4 T cells involving acquired MHC class II:peptide complexes: another mechanism to limit clonal expansion?
... (MHC) class II molecules are consti- tutively expressed on specialized antigen-presenting cells (APCs) such as dendritic cells (DCs) and ...macrophages. Antigen presentation by ...
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Downregulation of MHC class I molecules by human cytomegalovirusencoded
... Surface MHC class I molecules serve imp ortant immune functions as ligands for both T and N K cell recep tors for th e elimination of infected and malignant ...surface, MHC class ...
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Polymorphism of duck MHC class molecules
... Anpl-MHC I sequences, including UDA and UEA, retrieved from ...musculus MHC I (H-2), and BF2 were also retrieved and ...Anpl-MHC I sequences clustered to- gether, containing UDA ...
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Immunogenicity of Peptides Bound to MHC Class I Molecules Depends on the MHC-Peptide Complex Stability
... To study the relation between dissociation of peptides bound to MHC class I molecules and their ability to induce a CTL response, we used nine peptides derived from HBV[r] ...
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Class II MHC Self-Antigen Presentation in Human B and T Lymphocytes
... functional class II MHC-peptide complexes, but the endogenous peptide repertoire of these non-classical antigen presenting cells remains ...from MHC were derived from the common ...across ...
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Downregulation of MHC class I molecules by human cytomegalovirus-encoded US2 and US11
... of MHC class I m ...ed MHC class I h eav y ch ains and supports th eir dislocation to th e cytosol for sub seq uent deg radation b y proteasom ...idual class I ...
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Characterization of a Murine Cytomegalovirus Class I Major Histocompatibility Complex (MHC) Homolog: Comparison to MHC Molecules and to the Human Cytomegalovirus MHC Homolog
... these molecules both function as surrogate class I pro- teins, capable of engaging NK cell inhibitory receptors and protecting cells that lack class I surface ...mouse class ...
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