Antigen-presenting cells (APCs)
Engineered hydrogen bonded glycopolymer capsules and their interactions with antigen presenting cells
... of antigen presenting cells (APCs) such as dendritic cells (DCs), macrophages (MACs) or myeloid derived suppressor cells (MDSCs), can lead to different immune responses and ...
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Combination immunotherapy with TLR agonists and checkpoint inhibitors suppresses head and neck cancer
... B cells, and likely target stromal cells, but not tumor cells ...B cells when delivered ...immune cells — not on adaptive immune cells, which PD-1 blockade targets — we ...
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Original Article Specific killing effect of cytotoxic T cells induced by OCT4 and Sox2 on lung adenocarcinoma stem cells
... T cells induced by OCT4 and Sox2 on lung cancer stem cells was ...B cells (CD40-B) were used as the antigen presenting cells (APCs) to induce the CSC-specific CTL with the ...
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Distinct immune signatures in directly treated and distant tumors result from TLR adjuvants and focal ablation
... tumor antigen release, cross-presentation and cross-priming by the immune system after thermal ...B16 cells expressing ovalbumin (B16-OVA) at one site and a secondary B16 tumor line not expressing the ...
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A novel mycobacterial Hsp70-containing fusion protein targeting mesothelin augments antitumor immunity and prolongs survival in murine models of ovarian cancer and mesothelioma
... cancer cells. Numerous strat- egies that involve tumor antigen-specific and non- specific activation of the immune system have been ...[1-3]. Antigen-specific active immunotherapy is ex- pected to be ...
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Pesic, Marija (2013): Visualizing T cell activation around the blood-brain barrier Dissertation. Dissertation, LMU München: Fakultät für Biologie
... T cells recognizing myelin auto-antigens penetrate into the CNS to induce inflammatory autoimmune disease following complex sequential interactions with individual components of the vascular blood-brain barrier ...
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Myeloid-derived suppressor cells in non-neoplastic inflamed organs
... T cells and CD8 + T cells via NO produc- tion ex vivo ...T cells by the CD11b + Ly6C hi cells was determined by the MDSCs’ activation state and was plastic during the immune re- sponse ...T ...
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Validation of analytical methods in compliance with good manufacturing practice: a practical approach
... stem cells (BM MSCs) and Cytotoxic T Lymphocytes (CTLs), both cell therapy products that we will produce, in GMP conditions, for clinical trials of immunotherapy and regenerative medicine, and dendritic ...
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Strategies of adoptive T -cell transfer to treat refractory viral infections post allogeneic stem cell transplantation
... T cells in one single ...T cells by repetitively stimulating and expanding PBMCs with LCLs [25, ...CMV antigen pp65. These LCLs served as antigen-presenting cells for the in- ...
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Specific tolerance to an acetylcholine receptor epitope induced in vitro in myasthenia gravis CD4+ lymphocytes by soluble major histocompatibility complex class II peptide complexes
... T cells have been cloned from MG patients, and in this study, we have induced long-lasting tolerance in vitro in one particular clone (PM-A1) with a known peptide epitope (alpha 144-163) and MHC class II ...
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The interaction between gut microbiota and age-related changes in immune function and inflammation
... TLR-mediated NF-κB activation and colonization of the bowel by toxigenic bacterial strains, such as Helicobacter pylori, Bacteroides fragilis and Escherichia coli seems to contribute to the pathogenesis of CRC [33]. In ...
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Defects of T cell effector function and post thymic maturation in X linked hyper IgM syndrome
... tured in 1 ml of RPMI-1640 complete medium for 36 h. For anti-CD3ε stimulation, 64.1 antibody (gift of Bristol-Myers Squibb, Princeton, New Jersey, USA) was first dissolved in car- bonate buffer (pH 9.6) at a ...
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Endogenous antigen presentation by autoantigen transfected Epstein Barr virus lymphoblastoid cells I Generation of human thyroid peroxidase reactive T cells and their T cell receptor repertoire
... subsequently cloned in the presence of irradiated, autologous hTPO-transfected EBV-LCL and IL-2.10 T cell-cloned lines exhibited specific hTPO-induced proliferation (stimulation indices of 2.1-7.9) towards autologous ...
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Abnormalities in circulating plasmacytoid dendritic cells in patients with systemic lupus erythematosus
... T cells when compared with control pDCs. Using allogenous T cells as responder cells, SLE pDCs induced T cell proliferation even in the absence of apoptotic ...+ cells while SLE pDCs + apoPMNs ...
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A TCRα framework–centered codon shapes a biased T cell repertoire through direct MHC and CDR3β interactions
... (50,000 cells) were incubated with 1 ml virus-con- taining supernatant supplemented with 10 μg/ml polybrene and subjected to centrifugation (3,000 g) at 32°C for 90 ...T cells were cultured in RPMI with 10% ...
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Biology of IL-27 and its Role in the Host Immunity against Mycobacterium Tuberculosis
... Ablation of IL-27, either by disruption of the IL-27R gene in mice or by an antibody blockade of the IL-27R, implicates an important role of IL-27 in adap- tive immunity against mycobacteria infections. WSX-1-deficient ...
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Oral administration of taheebo (Tabebuia avellanedae Lorentz ex Griseb ) water extract prevents DSS induced colitis in mice by up regulating type II T helper immune responses
... The pathogenesis of IBD is characterized by the ex- cessive expansion of pro-inflammatory Th1 and Th17 cells and by the simultaneous reduction of Treg cells [1]. Because TWE has potent anti-inflammatory ef- ...
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Targeting tumor-necrosis factor receptor pathways for tumor immunotherapy
... tumor cells via perforin- and IFN-γ-dependent mechanisms ...stem cells accelerated disease progression and was associated with activation of the Wnt pathway ...
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Double negative (CD27−IgD−) B cells are expanded in NSCLC and inversely correlate with affinity matured B cell populations
... B cells was explored using linear regres- sion analysis of data collected from either the NSCLC tumors or normal lung ...B cells in normal lung tissue presenting with an estimate coefficient of ...B ...
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Transcriptional fingerprints of antigen-presenting cell subsets in the human vaginal mucosa and skin reflect tissue-specific immune microenvironments
... and antigen-presentation tran- scripts, consistent with a more mature ...- APCs and CD14 + APCs are concordant with the functional capacities we previously described, where vLCs and vCD14 - DCs ...
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