ANTIPROLIFERATIVE AGENTS
Systematic review of the potential role of cannabinoids as antiproliferative agents for urological cancers
... Overall, this study explored the current state of literature investigating the role of cannabinoids as antiproliferative agents in urological tumours. With the ever-increasing and popular role of THC in ...
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PYRAZOLE SCAFFOLD: A PROMISING TOOL IN THE DEVELOPMENT OF ANTIPROLIFERATIVE AGENTS
... potent antiproliferative agents that may target a variety of receptors such as vascular endothelial growth factor (VEGF), tyrosine kinase, Aurora-A kinase, protein kinase inhibitor, polo-like kinase ...
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Benzimidazole scaffolds as promising antiproliferative agents: a review
... Cancer is one of the most serious medical problem and second leading cause of death in the world, characterized by a deregulation of the cell cycle which mainly results in a progressive loss of cellular differentiation ...
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Molecular docking, synthesis and biological significance of pyrimidine analogues as prospective antimicrobial and antiproliferative agents
... Drug designing is a technique of searching and develop- ing new molecules that exert specific action on a human kind [1]. The figure of multidrug resistant microbial infections is growing day by day which indicated that ...
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Design, synthesis and biological profile of heterocyclic benzimidazole analogues as prospective antimicrobial and antiproliferative agents
... The antiproliferative activity was determined by SRB assay. Briefly, HCT116 was seeded onto the 96 well plate at 2500 cells/well. The cells were allowed to attach over- night before being exposed to the respective ...
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Cyclohexa-2,5-diene-1,4-dione-based antiproliferative agents: design, synthesis, and cytotoxic evaluation
... The quinoid anticancer agents undergo enzymatic re- duction via one or two electrons to give the correspond- ing semiquinone radical or hydroquinone. Under aerobic conditions the semiquinone radical anion can give ...
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The effects of growth factors and antiproliferative agents on ocular fibroblasts and wound healing after glaucoma filtration surgery
... A total of 36 rabbit eyes were treated with intraoperative water or antiproliferative treatment as outlined above. One hour, five days and 30 days after surgery, four animals were sacrificed with pentobarbital and ...
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Trisubstituted barbiturates and thiobarbiturates : synthesis and biological evaluation as xanthine oxidase inhibitors, antioxidants, antibacterial and antiproliferative agents
... Barbituric acid (BA) is a relevant pyrimidine derivative that was synthesized for the first time in 1864 by cyclization of urea and malonic acid [1]. Until the commercialization of benzodiazepines in the 1960s, ...
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Design, synthesis, ADME prediction and pharmacological evaluation of novel benzimidazole-1,2,3-triazole-sulfonamide hybrids as antimicrobial and antiproliferative agents
... Currently, a steady increase in the incidences of infec- tious diseases has occurred due to increasing drug resist- ance in microbial strains, which has become a major global public health issue [1]. This problem has ...
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Synthesis, molecular modelling and biological significance of N-(4-(4-bromophenyl) thiazol-2-yl)-2-chloroacetamide derivatives as prospective antimicrobial and antiproliferative agents
... anticancer agents [20, 21], the present study was undertaken to design, synthesize, molecularly dock and evaluate the biological potentials of N-(4-(4-bromophenyl)thiazol-2-yl)-2-chlo- roacetamide ...
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Synthesis and Biological Evaluation of Coumarin Derivatives as Antiproliferative Agents
... Chemotherapy drugs are sometimes feared because of its toxic effects. Their role is to slow and hopefully halt the growth spread of a cancer. There are three goals associated with the use of the most commonly used ...
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Isatin-benzoazine molecular hybrids as potential antiproliferative agents: synthesis and in vitro pharmacological profiling
... their antiproliferative activity against three human cancer cell lines, namely human colon cancer HT-29 cell line, breast cancer ZR-75 cell line and lung cancer A-549 cell ...
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Research Progress of Bonding Agents for Nitramine Composite Solid Propellants
... bonding agents, as the auxiliary agent of the composite solid propellants, can significantly improve the mechanical properties of solid propellant with low dosage and ...bonding agents have developed from ...
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Vehicle-based interactive management with multi-agent approach
... Figure 7 is the dial-a-ride interaction process diagram. We draw an interaction process diagram to help us to concrete the abstractive interaction concept. And we can realize the sequence of interaction between ...
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Characterization of the antiproliferative activity of Xylopia aethiopica
... Natural compounds have attracted considerable atten- tion as preventive and therapeutic agents against cancer [1]. Indeed, 74% of anticancer compounds are natural products or their derivatives. According to the ...
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Evaluation of antiproliferative activity of pyrazolothiazolopyrimidine derivatives
... effect. Antiproliferative action of compounds 2 and 7 dropped in the order: leukemia > melanoma > hepato- carcinoma > glioblastoma > colon carcinoma > breast and ovarian carcinoma ...
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Phytochemical Constituents and Pharmacological Activities of Picrasma javanica
... for antiproliferative activity has revealed that these quassinoids were active against human pancreatic cancer PANC- 1 cell ...additional antiproliferative activity in human cervical cancer HeLa cell ...
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Antiproliferative activity of Cucurbitaceae species
... of six crude organic extracts, tested against six human tumor cell lines, A549 (lung),.. 27.[r] ...
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Phenolics content, antiproliferative and antioxidant activities of Algerian Malva sylvestris
... The antiproliferative activity of plant extract was tested against three tumor cell lines: MCF-7, Hep2 and WEHI using 3-(4,5-dimethyl thiazol-2-yl)-2,5-diphynyl tetrazolium bromide (MTT) ...the ...
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In vitro Evaluation of Antiproliferative, Lipoxygenase and Xanthine Oxidase Inhibitory Activities of Artemisia nilagirica (C.B.Clarke) Pamp. Leaf Extracts
... Out of the three extracts ANH, ANM and ANA, only ANH and ANM showed antiproliferative activity in a concentration-dependent manner from 10-250 µg/ml in most of the cancer cells used in this study. ANA, on the ...
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