antisense oligonucleotides
Antisense oligonucleotides
... The genetic revolution led to the identification of many neu- rologic disease genes. The initial hope that finding the mutated protein and placing it into a known cellular pathway would lead to rapid development of ...
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Reduction of integrin alpha 4 activity through splice modulating antisense oligonucleotides
... of antisense oligonucleotides as therapeutics, there is an increasing interest in expanding the application of these compounds to many other ...modulating antisense oligonucleotides to treat ...
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Therapeutic potential of antisense oligonucleotides as modulators of alternative splicing
... of antisense 2′-deoxyoligonucleotides as agents for specific downregulation of gene expression is now well established ...the oligonucleotides base-pair with an mRNA target and mediate its destruction by ...
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Role of the intercellular adhesion molecule 1(ICAM 1) in endotoxin induced pneumonia evaluated using ICAM 1 antisense oligonucleotides, anti ICAM 1 monoclonal antibodies, and ICAM 1 mutant mice
... of antisense oligonu- cleotides targeted to intercellular adhesion molecule-1 (ICAM-1) to inhibit endotoxin-induced upregulation of ICAM-1 and neutrophil emigration and compared the apparent role of ICAM-1 when ...
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Systematic approach to developing splice modulating antisense oligonucleotides
... switching antisense oligonucleotides (AOs) are gaining interest as therapeutics for a wide variety of inherited and acquired diseases, with the approvals of Eteplirsen and Nusinersen to treat Duchenne ...
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Respirable antisense oligonucleotides: a new drug class for respiratory disease
... Respirable antisense oligonucleotides (RASONs), which attenuate specific disease-associated mRNAs, represent a new class of respiratory therapeutics with considerable ...of antisense therapeutics ...
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Antisense oligonucleotides extend survival and reverse decrement in muscle response in ALS models
... Dosing of mice. Intracerebroventricular (i.c.v.) infusions were performed as previously described (45). Surgeries were conducted according to Biogen Guidance for Aseptic Rodent Surgery. Animals were anesthetized by ...
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A Half-Century History of Applications of Antisense Oligonucleotides in Medicine, Agriculture and Forestry: We Should Continue the Journey
... Abstract: Antisense oligonucleotides (ASO), short single-stranded polymers based on DNA or RNA chemistries and synthesized in vitro, regulate gene expression by binding in a sequence-specific manner to an ...
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Brain pharmacology of intrathecal antisense oligonucleotides revealed through multimodal imaging
... Antisense oligonucleotides (ASOs) are promising drugs for the treatment of CNS disorders due to their specific molecular targeting and extended pharmacological properties ...
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Effect of Terminal Groups of Dendrimers in the Complexation with Antisense Oligonucleotides and Cell Uptake
... of antisense oligonucleotides (asODN) ...of antisense oligonucleotides as anticancer drugs could be a relatively easy task as they are the most dir- ect therapeutic method for mRNA blockade ...
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New treatments for myasthenia: a focus on antisense oligonucleotides
... Antisense oligonucleotides are designed to selectively hybridize with AChE m-RNA: this activates RNAses with subsequent degradation of the mRNA-antisense complex and aborted synthesis of the encoded ...
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The use of antisense oligonucleotides in evaluating survivin as a therapeutic target for radiation sensitization in lung cancer
... Elucidating the mechanism of over and under expression of proteins is critical in developing a better understanding of cancer. Multiple techniques are used to examine differential expression of proteins in cells and ...
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The experimental use of antisense oligonucleotides: a guide for the perplexed
... of oligonucleotides, but claim activity after examining only one, or at most two, ...one antisense oligomer was ...putative antisense oligonucleotides tested can be shown to be ...true ...
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POTENTIAL ROLE OF ANTISENSE OLIGONUCLEOTIDES IN REGULATION OF GENE EXPRESSION TO TARGET CANCER: A STEP FORWARD
... phosphodiester oligonucleotides, their use is limited as they are rapidly degraded by the intracellular endonucleases and ...modifications, Antisense Oligonucleotides are classified into three ...
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Inhibition of dengue virus by novel, modified antisense oligonucleotides.
... b-AS oligonucleotides at an intracellular concentration of 1 m M resulted in significantly less viral replication than the controls, at the lower ...for antisense inhibition (24), antisense ...
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Interleukin 6 antisense oligonucleotides inhibit the growth of human myeloma cell lines
... IL-6 antisense (and not sense) oligodeoxynucleotides; in the presence of 20 microM IL-6 antisense, an 80 and 95% inhibition of the proliferation of U 266 and RPMI 8226 cells was observed, ...
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Efficient inhibition of HIV 1 expression by LNA modified antisense oligonucleotides and DNAzymes targeted to functionally selected binding sites
... antisense to the single stranded loop of the DIS hairpin is very effective and sufficient to block dimerization. The inhibitory potential of the antisense oligos in vivo was dramatically improved upon LNA ...
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Antisense oligonucleotides extend survival of prion-infected mice
... Active ASOs 1 and 2 delayed the onset of prion disease clinical signs by 82% and 99%, respec- tively, compared with saline (median 250 and 272 days after infection [dpi] , respectively, [r] ...
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Functionalized halloysite nanotube based carrier for intracellular delivery of antisense oligonucleotides
... disorders. Antisense oligodeoxynu- cleotides [ASODNs] are single-strand DNA molecules complementary to regions of a target gene that specifically inhibit gene expression by hybridizing the gene ’ s mRNA ...
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Circular Antisense Oligonucleotides Inhibit Growth of Chronic Myeloid Leukemia Cells
... antisense circle reduced the amount of bcr-abl protein in treated cells, we used immunoblot- ting. BV173 cells were cultured with antisense or nonsense circle for 1, 2, or 3 days[r] ...
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