Antisense Oligonucleotides (ASO)
Brain pharmacology of intrathecal antisense oligonucleotides revealed through multimodal imaging
... of antisense oligonucleotides (ASOs) for the CNS have been successfully developed to treat spinal muscular ...However, ASO pharmacokinetic (PK) and pharmacodynamic (PD) properties remain poorly ...
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Antisense oligonucleotides
... of antisense oligonucleotides (ASOs) for therapy of neurologic ...of ASO action depends on the target se- quence and the precise ASO chemistry used in the ...of ASO action depending on ...
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A Half-Century History of Applications of Antisense Oligonucleotides in Medicine, Agriculture and Forestry: We Should Continue the Journey
... Abstract: Antisense oligonucleotides (ASO), short single-stranded polymers based on DNA or RNA chemistries and synthesized in vitro, regulate gene expression by binding in a sequence-specific manner ...
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Systematic approach to developing splice modulating antisense oligonucleotides
... switching antisense oligonucleotides (AOs) are gaining interest as therapeutics for a wide variety of inherited and acquired diseases, with the approvals of Eteplirsen and Nusinersen to treat Duchenne ...
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Therapeutic potential of antisense oligonucleotides as modulators of alternative splicing
... asthma. Antisense 2′-O-MOE oligonucleotides targeted to regions span- ning exon 9 were delivered to B cell lymphoma cells by electroporation ...of antisense oligonucleotides for downregulation ...
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Inhibition of dengue virus by novel, modified antisense oligonucleotides.
... b-AS oligonucleotides at an intracellular concentration of 1 m M resulted in significantly less viral replication than the controls, at the lower ...for antisense inhibition (24), antisense ...
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Respirable antisense oligonucleotides: a new drug class for respiratory disease
... Respirable antisense oligonucleotides (RASONs), which attenuate specific disease-associated mRNAs, represent a new class of respiratory therapeutics with considerable ...of antisense therapeutics ...
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Role of the intercellular adhesion molecule 1(ICAM 1) in endotoxin induced pneumonia evaluated using ICAM 1 antisense oligonucleotides, anti ICAM 1 monoclonal antibodies, and ICAM 1 mutant mice
... and antisense oligonucleotides are inducing more changes in endothelial cells than simply inhibiting the function or the expression of the targeted adhesion molecule, although their effects are likely to be ...
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New treatments for myasthenia: a focus on antisense oligonucleotides
... Antisense oligonucleotides are designed to selectively hybridize with AChE m-RNA: this activates RNAses with subsequent degradation of the mRNA-antisense complex and aborted synthesis of the encoded ...
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The experimental use of antisense oligonucleotides: a guide for the perplexed
... “scrambled” oligonucleotides provide superior con- ...quential oligonucleotides with two different back- ...an antisense mechanism is ...more oligonucleotides of different sequences that are ...
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Effect of Terminal Groups of Dendrimers in the Complexation with Antisense Oligonucleotides and Cell Uptake
... of antisense oligonucleotides (asODN) ...of antisense oligonucleotides as anticancer drugs could be a relatively easy task as they are the most dir- ect therapeutic method for mRNA blockade ...
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Reduction of integrin alpha 4 activity through splice modulating antisense oligonucleotides
... of antisense oligonucleotides as therapeutics, there is an increasing interest in expanding the application of these compounds to many other ...modulating antisense oligonucleotides to treat ...
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Antisense oligonucleotides extend survival and reverse decrement in muscle response in ALS models
... For many genetically linked neurodegenerative diseases, patients remain asymptomatic for more than 5 decades but when they develop signs of disease, the progression is relatively rapid over a period of about 5 years. ...
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Antisense oligonucleotides extend survival of prion-infected mice
... active ASO 2 at 120 ...active ASO 1 was tolerated at 120 dpi and because the control ASO, which does not lower PrP, elicited a similar response in some animals (sudden decline in 4 of 8 mice after ...
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Interleukin 6 antisense oligonucleotides inhibit the growth of human myeloma cell lines
... IL-6 antisense (and not sense) oligodeoxynucleotides; in the presence of 20 microM IL-6 antisense, an 80 and 95% inhibition of the proliferation of U 266 and RPMI 8226 cells was observed, ...
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Efficient inhibition of HIV 1 expression by LNA modified antisense oligonucleotides and DNAzymes targeted to functionally selected binding sites
... of oligonucleotides for in vivo applications. In this report the antisense effect of DNA and DNAzyme was compared to oligos that are modified with locked nucleic acid (LNA) ...the antisense oligo, it ...
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Functionalized halloysite nanotube based carrier for intracellular delivery of antisense oligonucleotides
... disorders. Antisense oligodeoxynu- cleotides [ASODNs] are single-strand DNA molecules complementary to regions of a target gene that specifically inhibit gene expression by hybridizing the gene ’ s mRNA ...
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Epigenetic synthetic lethality approaches in cancer therapy
... by antisense oligonucleotides (ASO) instead of an EZH2 inhibitor induces synthetic lethality in a variety of cancer cells with gain-of-function mutations of p53, such as partial breast cancer and ...
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Circular Antisense Oligonucleotides Inhibit Growth of Chronic Myeloid Leukemia Cells
... antisense circle reduced the amount of bcr-abl protein in treated cells, we used immunoblot- ting. BV173 cells were cultured with antisense or nonsense circle for 1, 2, or 3 days[r] ...
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Serotonin 5-Ht6 Receptor: A Potential Target For Cognition
... of Antisense oligonucleotides, antipeptide antibodies, selective radioligands, knockout mice, and selective antagonists of the 5-HT 6 receptor, the ...
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