Antitumor Drug
Supramolecular nanoparticles generated by the self-assembly of polyrotaxanes for antitumor drug delivery
... the antitumor drug doxoru- bicin was ...The drug-loaded nanoparticles were co-cultured with mouse 4T1 breast cancer cells to evaluate the in vitro antitumor efficacy, and the results showed ...
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Oil-in-water biocompatible microemulsion as a carrier for the antitumor drug compound methyl dihydrojasmonate
... an antitumor drug ...the drug presence, the droplet size was directly dependent on the oil/surfactant (O/S) ...the drug incorporation into the ME significantly increased the ME diameter, ...
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Oleanolic acid liposomes with polyethylene glycol modification: promising antitumor drug delivery
... able antitumor drug carriers due to their many ...Controlled drug delivery systems using liposomes can improve the biodistribution of existing anticancer drugs, and prolong drug accumulation ...
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<p>Smart Hydrogels – Synthetic Stimuli-Responsive Antitumor Drug Release Systems</p>
... step, drug- loaded micelles were incorporated into the smart pH-sen- sitive hydrogel, based on PEG-PCL-acryloyl chloride (AC) (PECA) modi fi ed by itaconic acid (IA) and PEG- methyl ether methacrylate ...intestinal ...
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A tissue-engineered subcutaneous pancreatic cancer model for antitumor drug evaluation
... Abstract: The traditional xenograft subcutaneous pancreatic cancer model is notorious for its low incidence of tumor formation, inconsistent results for the chemotherapeutic effects of drug molecules of interest, ...
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Role of protein kinase CK2 in antitumor drug resistance
... MLH1 component of the DNA mismatch repair complex MutLα [70], and the yeast proteins Lif1 (regulatory sub- unit of the NHEJ-specific DNA ligase IV) [71] and Ctp1 (DNA end-processing factor) [72]. Consistently, the spe- ...
15
Self-assembled micelles of novel amphiphilic copolymer cholesterol-coupled F68 containing cabazitaxel as a drug delivery system
... An antitumor drug, cabazitaxel, was homogenously incorporated into F68-CHMC micelles via a simple self- assembly method with a high entrapment efficiency and good dilution ...The drug-loaded F68-CHMC ...
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IN VIVO AND IN VITRO ANTITUMOR ACTIVITY OF A NOVEL PH ACTIVATED POLYMERIC DRUG DELIVERY SYSTEM FOR DOXORUBICIN
... Introduction: Conventional chemotherapy agent together with Doxorubicin (dox) is of limited clinical use because of its inherently low selectivity, that could lead to systemic toxicity in regular healthy tissue. Methods: ...
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IN VIVO EVALUATION OF THE ANTICANCER ACTIVITY OF A WATER IN GARLIC OIL NANOEMULSION LOADED WITH DOCETAXEL
... an antitumor drug used to treat various types of ...the antitumor activity and cardiotoxicity of the Doc loaded in a nanoemulsion formulated with the garlic oil (Doc-NEGO) in Ehrlich ascites ...
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A Nanosystem of Amphiphilic Oligopeptide-Drug Conjugate Actualizing Both αvβ3 Targeting and Reduction-Triggered Release for Maytansinoid
... of antitumor drugs [19, 20], and some of targeted delivery systems have already moved into clinical studies ...higher drug loading and possess higher safety [22], while are more favorable in terms of EPR ...
13
Two-photon AIE luminogen labeled multifunctional polymeric micelles for theranostics
... triggered drug release as well as charge-conversion induced enhancement of cell internalization for ...condition. Antitumor drug doxorubicin (DOX) is encapsulated and the drug release can be ...
13
Pluronic P105/F127 mixed micelles for the delivery of docetaxel against Taxol-resistant non-small cell lung cancer: optimization and in vitro, in vivo evaluation
... cell lines, DTX-loaded P105/F127 mixed micelles showed a superior hypersensitizing effect; their IC50 value (0.059 µg/mL) was greatly reduced compared to those of Taxotere injections (0.593 µg/mL). The in vivo ...
12
pH-sensitive and folic acid-targeted MPEG-PHIS/FA-PEG-VE mixed micelles for the delivery of PTX-VE and their antitumor activity
... quick drug release and to enhance its accumulation in tumor ...The drug encapsulation and loading efficiencies were ...micelles, drug delivery, in vivo antitumor ...
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Codelivery of doxorubicin and triptolide with reduction-sensitive lipid–polymer hybrid nanoparticles for in vitro and in vivo synergistic cancer treatment
... The cytotoxicity of coencapsulation of DOX and TPL in the same vehicle was higher than the mixture of DOX-LPNPs and TPL-LPNPs due to the simultaneous drug-release pro- files. Then, the synergistic effect was ...
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Nonspecifically enhanced therapeutic effects of vincristine on multidrug-resistant cancers when coencapsulated with quinine in liposomes
... The drug-loading content was defined as the weight ratio of loaded drug to the drug-loaded ...The drug encapsulation efficiency (EE) was cal- culated from the weight ratio between the ...
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NVP AUY922: a small molecule HSP90 inhibitor with potent antitumor activity in preclinical breast cancer models
... the drug discovery selection process for the optimal development candidate, NVP-AUY922 was administered intraperitonealy once per day to HCT16 colon tumor xenograft-bearing mice at a dose of 50 mg/kg ...the ...
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The application of EDTA in drug delivery systems: doxorubicin liposomes loaded via NH<sub>4</sub>EDTA gradient
... the drug would reach relatively low levels in other tissues, and lessen the risk of drug-related ...a drug formulation extra calcium might be eliminated owing to its chelating effect, and suffering ...
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Photodynamic Therapy Using Novel Zinc Phthalocyanine Derivatives and a Diode Laser for Superficial Tumors in Experimental Animals
... excellent antitumor activity in vitro; therefore, photosensitizers were evaluated in an in vivo antitumor assay system using fertilized chicken ...luate antitumor activity in vivo have been carried ...
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Bioreducible nanocapsules for folic acid-assisted targeting and effective tumor-specific chemotherapy
... In this work, we propose a simple yet efficient method to prepare the hydrogel-like nanocapsules and provide construc- tion strategies to govern their transportation and responses toward tumor microenvironments for ...
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Two-dose-level confirmatory study of the pharmacokinetics and tolerability of everolimus in Chinese patients with advanced solid tumors
... Preclinical studies have shown that everolimus inhibits proliferation of a wide spectrum of human solid tumors in vitro and in vivo [12-14]. Pharmacokinetic (PK) stu- dies of everolimus in patients with advanced solid ...
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