Antiviral responses
Connexin Dependent Transfer of cGAMP to Phagocytes Modulates Antiviral Responses
... Since we also observed potentiation of macrophages cultured with the conditioned medium of cGAMP producing cells, we propose that connexin-dependent transfer of cGAMP represents one of several modes of phagocyte ...
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Defective Antiviral Responses of Induced Pluripotent Stem Cells to Baculoviral Vector Transduction
... In light of the aforementioned data, we conclude that iPSCs are distinct from other cells such as MSCs in terms of their antiviral responses. In MSCs, BV transduction disturbed the expression of 816 genes, ...
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Cardiac Cell Type-Specific Antiviral Responses and Mechanisms of Viral Antagonism of Cellular Innate Responses.
... inflammatory responses are important factors in cardiac antiviral ...signaling responses are critical in the development of myocarditis, regulation of these responses is a major target of ...
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Topoisomerase 1 Inhibition Promotes Cyclic GMP AMP Synthase Dependent Antiviral Responses
... cGAS-dependent antiviral immune ...immune responses (such as in bacterial and viral infections), as has been recently proposed ...induce antiviral responses in normal cells (9), low-dose CPT ...
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Novel immune genes associated with excessive inflammatory and antiviral responses to rhinovirus in COPD
... Antiviral responses such as IFN-β and -λ1 are critical in limiting viral replication, and were significantly higher in COPD ...enhanced antiviral responses associated with increased ...
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Aedes aegypti Piwi4 Is a Noncanonical PIWI Protein Involved in Antiviral Responses
... no antiviral activity could be linked to the piRNA pathway in ...the antiviral role of the piRNA pathway in ...these antiviral responses remains ...
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Role of microRNAs in antiviral responses to dengue infection
... Dengue virus (DENV) is the etiological agent of dengue fever. Severe dengue could be fatal and there is currently no effective antiviral agent or vaccine. The only licensed vaccine, Dengvaxia, has low efficacy ...
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IL 12 in conjunction with dendritic cells enhances antiviral CD8+ CTL responses in vitro
... human antiviral CD8 1 T cell re- ...baseline antiviral responses, the effect of adding IL-12 was ...strong antiviral immune response was elicited where little to none could be previously ...
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Virus-like infection induces human β cell dedifferentiation
... By mining our transcriptomic data, we observed that PolyI:C treatment induced the expression of sev- eral genes linked to antiviral responses, coding for chemokines or for proteins relat[r] ...
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Human Metapneumovirus M2-2 Protein Inhibits Innate Cellular Signaling by Targeting MAVS
... host antiviral responses to hMPV infection, logarithmically growing 293 cells were transfected in triplicate with luciferase reporter gene plasmids containing IFN-  promoter (designated IFN-  -Luc) or ...
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Pandemic H1N1 2009 Influenza A Virus Induces Weak Cytokine Responses in Human Macrophages and Dendritic Cells and Is Highly Sensitive to the Antiviral Actions of Interferons
... immune responses in pandemic virus-infected human monocyte-derived dendritic cells (DC) and ...of antiviral and proinflammatory ...the antiviral IFN- 3 than the seasonal A/Brisbane/59/07 (H1N1) ...
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PPAR-γ in Macrophages Limits Pulmonary Inflammation and Promotes Host Recovery following Respiratory Viral Infection
... host antiviral responses with the concomitant development of severe lung injury during respiratory viral infections ...their responses are not tightly ...
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Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1
... ABSTRACT Recognition of virus-derived nucleic acids by host pattern recognition receptors (PRRs) is crucial for early defense against viral infections. Recent studies re- vealed that PRRs also include several newly ...
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Intranasal administration of poly gamma glutamate induced antiviral activity and protective immune responses against H1N1 influenza A virus infection
... Because influenza viruses enter through a mucosal sur- face, preventing infection at the viral entry site by inducing mucosal immunity via intranasal immunization is an at- tractive strategy for influenza protection. In ...
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Suppression of Acute Viremia by Short-Term Postexposure Prophylaxis of Simian/Human Immunodeficiency Virus SHIV-RT-Infected Monkeys with a Novel Reverse Transcriptase Inhibitor (GW420867) Allows for Development of Potent Antiviral Immune Responses Resulting in Efficient Containment of Infection
... Subsequent analyses of samples obtained at 50, 62, 76, and 90 weeks p.i. indicated that plasma viral RNA levels were maintained below 1,000 copies/ml in each of the six drug- treated animals. Results of the proviral DNA ...
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Virological Control by the CD4-Binding Site Antibody N6 in Simian-Human Immunodeficiency Virus-Infected Rhesus Monkeys
... IMPORTANCE Monocloncal antibodies (MAbs) are being considered for passive im- munotherapy of HIV-1 infection. A critical requirement for such strategies is the identification of MAbs that recognize the diversity of ...
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Interleukin-12 (IL-12), but Not IL-23, Deficiency Ameliorates Viral Encephalitis without Affecting Viral Control
... immune responses (15, 18, 26, 31, ...immune responses to lymphocytic choriomeningitis virus; IFN- ␥ is nevertheless re- quired for resistance to both of these infections (31, 33, ...
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Sequence-Specific Modifications Enhance the Broad-Spectrum Antiviral Response Activated by RIG-I Agonists
... host antiviral innate ...the antiviral and inflammatory responses in human epithelial A549 cells, human innate immune primary cells, and murine models of influenza and chikungunya viral ...modulate ...
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Evaluation of the Immune Responses to and Cross-Protective Efficacy of Eurasian H7 Avian Influenza Viruses
... antibody responses and cross-protective efficacy, only Anhui1/13 was able to cross-protect immunized hosts against lethal challenge across ...antibody responses against both groups of ...
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Antiviral immune responses in mice deficient for both interleukin-2 and interleukin-4.
... immune responses of mice lacking interleukin-2 (IL-2) or IL-4 or both IL-2 and IL-4 (IL-2/4) were compared by using different ...(CTL) responses against lymphocytic choriomeningitis virus (LCMV) were only ...
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