Antiviral state
Investigation of antiviral state mediated by interferon inducible transmembrane protein 1 induced by H9N2 virus and inactivated viral particle in human endothelial cells
... the antiviral activity of IFITM1 induced by H9N2 virus and viral particle in ...the antiviral state mediated by IFITM1 in ...the antiviral state of HUVECs against H9N2 virus ...
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Reversible Inhibition of Murine Cytomegalovirus Replication by Gamma Interferon (IFN-γ) in Primary Macrophages Involves a Primed Type I IFN-Signaling Subnetwork for Full Establishment of an Immediate-Early Antiviral State
... It is possible that the reporter system used in these assays does not represent the endogenous MIEP activity. To determine if the measurement of the reduced reporter gene levels in our system accurately reflects MIEP ...
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Sendai Virus C Proteins Counteract the Interferon-Mediated Induction of an Antiviral State
... the antiviral state rather than simply avoiding the induction, although it might do this as ...an antiviral state, because many viruses are known to subvert the IFN system by a wide variety of ...
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Herpes Simplex Virus Virion Host Shutoff Attenuates Establishment of the Antiviral State
... the antiviral state are also poorly ...dsRNA-inducible antiviral pathways such as PKR and RNase ...the antiviral state, such as IFN genes and ISGs, as evidenced by the altered ...
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Inhibitors of the Histone Methyltransferases EZH2/1 Induce a Potent Antiviral State and Suppress Infection by Diverse Viral Pathogens
... cellular antiviral state that also suppressed infection with DNA (human cytomegalovirus, adenovirus) and RNA (Zika virus) ...cellular antiviral and immune ...
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Axl Promotes Zika Virus Entry and Modulates the Antiviral State of Human Sertoli Cells
... FIG 4 Axl suppresses the antiviral state of human SC. (A) Protein expression of total and phosphorylated STAT1 (p-STAT1), SOCS1, and SOCS3 was determined in total cell lysates from mock-infected and ...
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Mouse peritoneal cells confer an antiviral state on mouse cell monolayers: role of interferon.
... The above experiments showed that the capacity of peritoneal cells to confer an antiviral state on target monolayer cultures of mouse embryonic fibroblasts or aged mouse macrophages was [r] ...
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Phagocytosis of Picornavirus-Infected Cells Induces an RNA-Dependent Antiviral State in Human Dendritic Cells
... instructing antiviral immune ...an antiviral state in human ...an antiviral state in ...an antiviral state in human ...
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Species specificity of interferon action: maintenance and establishment of the antiviral state in the presence of a heterospecific nucleus.
... B HeLa cell cytoplasts derived from HeLa cells treated overnight with human interferon 438 U/ml, 4 ml were fused with 1 untreated L cells or 2 untreated HeLa cells and then assayed for t[r] ...
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Adaptation to the Interferon-Induced Antiviral State by Human and Simian Immunodeficiency Viruses
... These findings lead to the conclusion that at least one undis- covered ISG is present in cells of macaque origin that can inhibit HIV-1 replication therein. They also suggest that at least one un- discovered ISG is ...
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Interferon-induced proteins in human fibroblasts and development of the antiviral state.
... The induction of these proteins had features in common with the development of the antiviral effect of interferon, such as i sensitivity to actinomycin D and cycloheximide when these com[r] ...
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Establishment and Maintenance of the Interferon-Induced Antiviral State: Studies in Enucleated Cells
... These cover slips were scheme I significant increase in the mean number of virus interferon IF-treated prior to enucleation material factories per single cell in the IF-treated cells fro[r] ...
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Induction and Antagonism of Antiviral Responses in Respiratory Syncytial Virus-Infected Pediatric Airway Epithelium
... potent antiviral state in these cultures and that a type III interferon, interleukin IL-29 (IL-29), was in- ...this antiviral immune response and identified mechanisms by which this may ...
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Antiviral Response in Cells Containing Stat1 with Heterologous Transactivation Domains
... The inhibition by alpha interferon (IFN-␣) and IFN-␥ of viral infection depends upon the full transcriptional activation capacity of Stat1 and Stat2 proteins (9, 37). These transcription factors are latent in the ...
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Murine Coronavirus Delays Expression of a Subset of Interferon-Stimulated Genes
... the antiviral effects of IFN- ␣ /  ...-induced antiviral state, whereas IFN treatment of cell lines (L2 and 293T) has only minor effects on replication ...
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Knockout of cGAS and STING Rescues Virus Infection of Plasmid DNA-Transfected Cells
... M ammalian cells express various receptors to sense invading pathogens. Specialized receptors that survey the intracellu- lar milieu are the NOD-like receptors (NLRs), the RIG-I-like re- ceptors (RLRs), and numerous ...
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Cloning and sequence analyses of cDNAs for interferon- and virus-induced human Mx proteins reveal that they contain putative guanine nucleotide-binding sites: functional study of the corresponding gene promoter.
... The rate of decay of p78 levels in diploid cells after a 24-h treatment with IFN-a was much slower than the rate of decay of the antiviral state against influenza A virus and vesicular s[r] ...
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Human IFIT1 Inhibits mRNA Translation of Rubulaviruses but Not Other Members of the Paramyxoviridae Family
... powerful antiviral defense system that, unless counteracted by viruses, will limit their repli- cation to such a degree that they will not cause disease or be effi- ciently transmitted between susceptible hosts ...
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Mammalian Adaptation of an Avian Influenza A Virus Involves Stepwise Changes in NS1
... As NS1 proteins harboring E186 bind CPSF30, we wanted to check if during viral infection NS1 would be present in the same intracellular compartment as CPSF30 (i.e., the nucleus). All the proteins exhibited similar ...
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Blockage of antiviral induction of interferon by homologous cell biochemical activity: effect of chicken embryo fibroblast mitotic cell cycle phases on Sindbis virus growth.
... a Antiviral state conferred by interferon and calculated as log reduction of viral yield = log yield of control cells - log yield of interferon-treated cells represented in relation to c[r] ...
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