Aortic Rings
Investigation of the mechanisms of Angelica dahurica root extract induced vasorelaxation in isolated rat aortic rings
... Oxypeucedanin, oxypeucedanin hydrate, imperatorin, and isoimperatorin are well known components of A. dahurica root [37–40]. In the present study, these four components were also found in ADE and the contents were ...
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Vasorelaxation by the Aqueous Extract of Juliana Adstringens on Rat Aortic Rings
... some rings, the endothelium was removed by gently rubbing the inner surface with a glass ...The aortic rings were placed in tissue chambers containing 10 ml of Krebs-bicarbonate solution, of the ...
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Original Article Iloprost relaxes phenylephrine-precontracted rat aortic rings
... ephrine precontracted rat aortic rings com- pared to widely used agents such as papaver- ine, diltiazem and nitroglycerin. Considering the mean maximal relaxation, papaverine had the highest efficacy ...
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Adenosine and lidocaine (AL) combination dilates intimally damaged rat thoracic aortic rings and guinea pig mesenteric arteries: possible significance to cardiac surgery
... segments. Aortic rings were equilibrated in a standard 10 ml vol- ume organ bath (Radnotti Glass, AD instru- ments, NSW, AUS) containing Krebs-Henseleit ...The rings were verti- cally mounted on ...
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First Report ofEurycoma longifoliaJack Root Extract Causing Relaxation of Aortic Rings in Rats
... rat aortic rings, was further purified by column ...PE-precontracted rings treated with DCM-II, the Ang II-induced contraction was attenuated (𝑝 < ...
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Vasorelaxant effects of Angelica decursiva root on isolated rat aortic rings
... decursiva root; CaCl2: Calcium chloride; CVD: The cardiovascular disease; DMSO: Dimethyl sulfoxide; EGTA: Ethylene glycol-bis 2-aminoethyletherN,N,N′,N′-tetra acetic acid; KATP: ATP-sens[r] ...
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Comparative Effect of Type 1 and Type 2 Diabetes Mellitus on Vascular Responses of Rat Thoracic Aorta to Potassium Ion Channel Openers
... The relaxation induced by the flavonoid, (+/-)-naringenin was significantly reduced in the aorta from STZ-diabetic rat when compared with age-matched control (Fig. 4A). The maximal relaxation of aortic ...
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Antiangiogenesis and antioxidant activity of ethanol extracts of Pithecellobium jiringa
... Briefly, aortic rings of about 1 mm thickness excised from thoracic aortas were placed into a 48-wells plate filled with 300 μl of serum-free M199 medium supple- mented with 3 mg/ml fibrinogen, 5 μg/ml ...
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Endothelium derived relaxation factors reduce sulfur dioxide induced aortic relaxation
... thoracic aortic rings caused contraction-dependent inhibition of the PE-induced contraction, in both, endo- thelium-intact and endothelium-denuded preparation (Fig- ure ...
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Syzygium campanulatum korth methanolic extract inhibits angiogenesis and tumor growth in nude mice
... of several angiogenesis related disorders. In this context, several plant-derived compounds have shown promising antiangiogenic and antitumor effects such as ursolic acid [5], oleanolic acid [6], lupeol [7], betulinic ...
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Mechanisms of the anti hypertensive effect of Hibiscus sabdariffa L calyces
... in aortic tone by stimulating Ca 2+ influx through voltage and receptor oper- ated Ca 2+ channels (Bolton, 1979; Karaki and Weiss, ...rat aortic rings (Obiefuna et ...
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Activated protein C increases sensitivity to vasoconstriction in rabbit Escherichia coli endotoxin induced shock
... E- rings from the CTRL ...LPS-treated aortic rings (as observed in the CTRL ...of aortic rings to PE when aPC is administered to non-endotoxinic ani- mals (the EC 50 of E+ rings ...
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Effect of Peroxynitrite (ONOO ) on the Function of Murine Perivascular Adipose Tissue
... thoracic aortic PVAT is a potent source of reactive oxygen species (ROS) due to the abundance of mitochondria in the brown adi- pocytes and that the dismutation product of superoxide-hydrogen peroxide can ...
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Potassium channel openers and prostacyclin play a crucial role in mediating the vasorelaxant activity of Gynura procumbens
... In order to investigate whether the F1 could affect the K + channel opening during vasorelaxation, 4-aminopyridine (1 mM), a blocker of the voltage-activated K + channel; TEA (1 mM), a selective blocker to Ca 2+ ...
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Effect of cymbopogon citratus and citral on vascular smooth muscle of the isolated thoracic rat aorta
... Cymbopogon citratus has been shown to have antioxidant, antimicrobial, antispasmodic and chemo-protective properties. Citral, is the major constituent of C. citratus. This study investigated the effects of methanolic ...
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Adenosine and lidocaine (AL) as a vasodilator in cardiac procedures and a storage solution for vascular banking
... contracted rings if the endothelium is intact, and will have little or no effect if the endothelium is denuded (or damaged) leaving the rings in a contracted state (Furchgott & Zawadzki, ...thesis, ...
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Pulmonary vasoreactivity in spontaneously hypertensive rats - Effects of endothelin-1 and leptin
... thoracic aortic rings and were enhanced in endothelium-denuded rings (Figure ...artery rings, endothelin-1 (10 nmol/L) induced a higher level of contraction in pulmonary artery compared to ...
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Blood pressure lowering by pioglitazone Evidence for a direct vascular effect
... thiazolidinedione compound, pioglitazone (PIO), we studied the effects of the drug on blood pressure and insulin action in vivo and on vascular tissue in vitro. In vivo, PIO lowered blood pressure in fructose-fed and ...
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QUANTIFICATION OF ANGIOGENESIS ON THE RAT AORTIC RING ASSAY
... Angiogenic parameters were automatically evaluated on rat aortic rings after 8 of culture in the following situations: (i) a spontaneous angiogenic response and (ii) a VEGF-induced angiogenesis. From Table ...
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Direct effects of quercetin on impaired reactivity of spontaneously hypertensive rat aortae: comparative study with ascorbic acid
... Figure 2 illustrates the relaxant responses to endothelium- independent vasodilator, SNP, in all experimental groups. The maximal relaxant response to SNP was significantly lesser in control SHR aortic ...
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