APC, activated protein C
Anti factor Xa antibodies in patients with antiphospholipid syndrome and their effects upon coagulation assays
... ACT: activated clotting time; ALP: alkaline phosphatase; APC: activated protein C; aPL: antiphospholipid antibody; APS: antiphospholipid syndrome; ARD: autoimmune rheumatic disease; ...
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Laboratory evaluation of bleeding diathesis in medical ICU patients.
... ABBREVIATIONS USED IN THE TEXT AIDP - Acute Inflammatory Demyelinating Polyradiculopathy AKI - Acute Kidney Injury APC - Activated Protein C APLA - Anti Phospholipid Antibody syndrome aP[r] ...
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Endogenous plasma activated protein C levels and the effect of enoxaparin and drotrecogin alfa (activated) on markers of coagulation activation and fibrinolysis in pulmonary embolism
... APC: Activated protein C; aPTT: Activated partial thromboplastin time; BW: Body weight; CT: Computerized tomography; DAA: Drotrecogin alfa (activated); recombinant ...
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The Leiden Thrombophilia Study (LETS)
... In this way the role of a deficiency of protein C, protein S or antithrombin and of APC (activated protein C) resistance, elevated von Willebrand factor and factor VIII:c levels, hyperho[r] ...
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Incident venous thromboembolic events in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER)
... apolipoprotein; APC: activated protein C; AST: aspartate aminotransferase; BMI: body mass index; CHD: coronary heart disease; CRP: C reactive protein; DBP: diastolic blood ...
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Closed Or Open after Source Control Laparotomy for Severe Complicated Intra-Abdominal Sepsis (the COOL trial): study protocol for a randomized controlled trial
... ANPPT: Active negative pressure peritoneal therapy; APACHE: Acute Physiology and Chronic Health Evaluation; APC: Activated protein C; ARDS: Acute Respiratory Distress Syndrome; AUC: Area[r] ...
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Anti factor Xa antibodies in patients with antiphospholipid syndrome and their effects upon coagulation assays
... ACT: activated clotting time; ALP: alkaline phosphatase; APC: activated protein C; aPL: antiphospholipid antibody; APS: antiphospholipid syndrome; ARD: autoimmune rheumatic disease; ...
10
Thrombomodulin/activated protein C system in septic disseminated intravascular coagulation
... (TM)/activated protein C (APC) system plays an important role in maintaining the homeostasis of thrombosis and hemostasis and maintaining vascular integrity in ...activates protein ...
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Upregulated but insufficient generation of activated protein C is associated with development of multiorgan failure in severe acute pancreatitis
... patients. In an animal model of AP, the PC level was found to decline already one hour after initiation of AP [29]. The PC lev- els often fall rapidly in sepsis patients [30,31], and this may associate with the ...
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Recombinant activated protein C treatment improves tissue perfusion and oxygenation in septic patients measured by near infrared spectroscopy
... The steady-state tissue oxygenation (StO 2 baseline ) did not change as a result of rh-aPC treatment, which indicates that the balance between tissue oxygen delivery and consumption is unaltered by rh-aPC ...
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The clinical and functional relevance of microparticles induced by activated protein C treatment in sepsis
... facilitate APC proteolytic anticoagu- lant activity ...the APC-PAR1 pathway is physiologically relevant because MP-EPCR release is dependent on PAR1 activation by APC ...ciated APC remains to ...
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Stroke Due to Hypercoagulable State Can Mimic Multiple Sclerosis: A Case Report
... In 1994, Bettina and colleagues described a common variation (G 1691A) in the factor V gene as a molecular defect responsible for activated protein C (APC) resistance, a previously ...
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APCAP activated protein C in acute pancreatitis: a double blind randomized human pilot trial
... In our study we found no severe bleeding associated with APC treatment. The main purpose of this pilot study was to focus on this issue, because the increased risk of bleeding with APC has raised concerns ...
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Recombinant human activated protein C attenuates endotoxin induced lung injury in awake sheep
... Protein C is an inactive precursor of the serine protease acti- vated protein C (APC), which is catalyzed by the action of thrombin/thrombomodulin complex when protein C ...
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Influence of Factor V Leiden on susceptibility to and outcome from critical illness: a genetic association study
... of activated protein C (APC) for treatment of severe ...of APC could modulate the effect of the Factor V Leiden ...on APC use in these two cohorts was unavailable but a very ...
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The Role of Protein C, Protein S, and Resistance to Activated Protein C in Legg-Perthes Disease
... of protein S deficiency were excluded from the ...the protein C and protein S assays from 4 cases and 3 controls was not obtained, and for the same reason, the APC-R assay was not done ...
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Inhibition of activated protein C by platelets
... of APC to achieve a similar degree of ...of APC was observed and the anticoagulant effect was similar to that obtained with ...and APC. The activity of the platelet APC inhibitor ...
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Inhaled aerosolised recombinant human activated protein C ameliorates endotoxin induced lung injury in anaesthetised sheep
... that APC possesses the ability to modulate various forms of ALI in sheep ...infused APC, at the same dose as used for treatment of severe sepsis, improves oxygenation and reduces the increments in Pmo and ...
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Recombinant human activated protein C ameliorates oleic acid induced lung injury in awake sheep
... human APC (rhAPC) increases survival from severe sepsis ...tein C decreases markedly in patients with ALI, whether of septic or non-septic origin, and a low plasma level of protein C is ...
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Microcirculatory alterations in ischemia–reperfusion injury and sepsis: effects of activated protein C and thrombin inhibition
... treatment. APC and antithrombin have been used in experimental models to reduce ischemia– reperfusion injury and to improve septic disorders with comparable ...of APC and antithrombin during ...
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