ApoE-deficient mice
Liver directed gene transfer and prolonged expression of three major human ApoE isoforms in ApoE deficient mice
... major apoE isoforms on lipoprotein metabolism in ...man apoE isoforms on lipoprotein metabolism in the absence of endogenous apoE by utilizing liver-directed somatic gene transfer in ...
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Original Article The antiatherosclerotic and antianxiety-like effects of the Cordyceps sobolifera mycelium in apoE deficient mice
... in apoE deficient mice. The mice were fed a high fat and high cholesterol diet and CSM for 12 ...the mice had lesions in the aorta. However, compared with the control mice, the ...
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Abundant progenitor cells in the adventitia contribute to atherosclerosis of vein grafts in ApoE deficient mice
... Immunohistochemical staining revealed that the adventitia in aortic roots harbored large numbers of cells having stem cell markers, e.g., Sca-1 + (21%), c-kit + (9%), CD34 + (15%), and Flk1 + cells (4%), but not SSEA-1 + ...
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Macrophage expression of active MMP 9 induces acute plaque disruption in apoE deficient mice
... by macrophages, there was only a minor increase in the incidence of plaque fissuring. Subsequent analysis revealed that macrophages secrete MMP-9 predominantly as a proform, and this form is unable to degrade the matrix ...
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Inhibitory effects of Mycoepoxydiene on macrophage foam cell formation and atherosclerosis in ApoE-deficient mice
... Mycoepoxydiene (MED) is a novel polyketide that can be isolated from the marine fungus Diaporhte sp. (D.sp.) HLY-1 and was discovered in submerged rotten leaves of Kandelia candel in a mangrove forest in Fujian Province, ...
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Overexpression of endothelial nitric oxide synthase accelerates atherosclerotic lesion formation in apoE deficient mice
... of apoE-KO/eNOS-Tg ...in apoE- KO/eNOS-Tg mice was more extensively distributed and significantly increased not only in the atheroscle- rotic plaque, but also in nonplaque areas, as compared with ...
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Adenovirus-Mediated Prothymosin α Gene Transfer Inhibits the Development of Atherosclerosis in Apoe-Deficient Mice
... significant difference between the AdProT- and AdLacZ-treated groups in body weight and in levels of plasma cholesterol 4 weeks after virus treatment (data not shown). In the previous studies, inhibition of SOD leads to ...
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A novel CCR2 antagonist inhibits atherogenesis in apoE deficient mice by achieving high receptor occupancy
... progression would be favorable to prevent an existing plaque to progress to an advanced and unstable lesion. In this study, 15a almost completely blocked lesion initiation in the carotid artery, as treatment was ...
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Inhibitory effect of the combination therapy of simvastatin and pinocembrin on atherosclerosis in apoE-deficient mice
... The ApoE −/− mouse is a well-established genetic mouse model of atherogenic hypercholesterolemia, even with normal diet which spontaneously develops atheroscler- osis with similar features to those observed in ...
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Roles of thromboxane A2 and prostacyclin in the development of atherosclerosis in apoE deficient mice
... Atherosclerotic lesions in the innominate artery were quantified by cross-sectional analysis. Innominate arteries were isolated from 45-week- old male mice sacrificed by cervical dislocation, were washed in PBS, ...
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Iron overload diminishes atherosclerosis in apoE deficient mice
... high-iron diet than in the control animals, suggesting that iron overload actually retarded lesion formation. Although the reason for this remains unclear, there are several poten- tial mechanisms. One involves the ...
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Gene Expression in Atherosclerotic Lesion of ApoE Deficient Mice
... In addition to the established atherosclerosis- associated genes, several new candidate genes were found up-regulated in ApoE-/- mice. The macro- phage chemoattractant protein-3 (MCP-3) (Table 3), a ...
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Effects of Shenlian extract on experimental atherosclerosis in ApoE deficient mice based on ultrasound biomicroscopy
... male ApoE -/- mice (aged 9 weeks old, on the C57BL/6 J genetic background) and ten male C57BL/6 J mice were purchased from HFK bioscience ...China). Mice were maintained at an environ- mental ...
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Potential implications of Apolipoprotein E in early brain injury after experimental subarachnoid hemorrhage: Involvement in the modulation of blood-brain barrier integrity
... of APOE began to rise as early as 6h after SAH ...post-injury, APOE was significantly increased and then peaked at 48h, followed by a gradual decline toward the baseline at 72h post-injury in the ...
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Sex differences in the development of vascular and renal lesions in mice with a simultaneous deficiency of Apoe and the integrin chain Itga8
... of Apoe develop hypercholesterol- emia followed by progressive atherosclerotic lesions [1, ...although Apoe-deficient mice without an atherogenic diet do not commonly develop overt renal ...
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Severe pulmonary hypertension in aging female apolipoprotein E-deficient mice is rescued by estrogen replacement therapy
... in ApoE-deficient, but not in WT female ...only ApoE-deficient MA female mice points towards the possible interplay between advancing age, cessation of estrous cyclicity, and in- ...
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Natural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunity
... from apoE-defi- cient mice, which have very high titers of autoantibodies to Cu-OxLDL ...two apoE-deficient mice that had not been immunized exogenously were fused with the P3 × ...
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Will absence of GPAT1 improve diet-induced atherosclerosis in ApoE heterozygous mice?
... in apoE +/- mice or apoE +/- - GPAT1 -/- ...fed apoE-deficient mice for 4-5 weeks with a western-style diet (21% fat, and ...
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Apolipoprotein E deficiency in mice: gene replacement and prevention of atherosclerosis using adenovirus vectors
... in apoE-deficient mice with preinfusion plasma total cholesterol of 644 +/- 149 mg/dl an cholesterol rich ...human apoE ranging from ...mediated apoE replacement resulted in ...
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An apolipoprotein E synthetic peptide targets to lipoproteins in plasma and mediates both cellular lipoprotein interactions in vitro and acute clearance of cholesterol rich lipoproteins in vivo
... an apoE peptide that bound to both cholesterol-rich lipoproteins and lipoprotein receptors, an NH2-terminal acetylated apoE dimer peptide was ...C57BL/6J apoE-deficient mice, its rate ...
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