Apoptosis resistance
Increased survivin expression contributes to apoptosis resistance in IPF fibroblasts
... fibroblast resistance to apoptosis as a contributing ...fibroblast resistance to ...induced apoptosis resis- tance in normal lung fibroblasts through the upregu- lation of survivin, a member ...
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MicroRNA 362 induces cell proliferation and apoptosis resistance in gastric cancer by activation of NF κB signaling
... We investigated the underlying molecular mechanism that might be responsible for the oncogenic roles of miR-362. As the NF-κB signaling pathway is frequently found hyperactivated in gastric tumors [11,34,35], and ...
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Oncogenic Ras suppresses ING4-TDG-Fas axis to promote apoptosis resistance
... regulating apoptosis, we treated the TDG overexpression cells with TNFα and FasL, two major inducers of extrinsic ...induced apoptosis of pancreatic cancer cells only in the presence but not absence of TDG ...
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<p>PKMYT1 Promotes Gastric Cancer Cell Proliferation and Apoptosis Resistance</p>
... such as proliferation, apoptosis, and survival. 11,12 Our previous data revealed that PKMYT1 is closely related to the cell proliferation and anti-apoptosis of GC cells. Therefore, we compared and analyzed ...
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Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) promotes lung fibroblast proliferation, survival and differentiation to myofibroblasts
... conferred apoptosis resistance in an E-cadherin dependent manner and down regulation of EMMPRIN inhibited cell–cell contact formation, which induced cell ...from apoptosis [36]. Other studies have ...
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Carcinoembryonic Antigen Expression and Resistance to Radiation-and 5-Fluorouracil-Induced Apoptosis and Autophagy
... and apoptosis. Resistance to anticancer drugs such as 5-FU is a common cause of failure in CRCchemotherapy ...cell resistance to chemotherapy and radiotherapy is one of the most important obstacles ...
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Tumour stromal interactions: Integrins and cell adhesions as modulators of mammary cell survival and transformation
... Although genetics undoubtedly plays a critical role in driving malignant transformation and apoptosis resistance in the breast, evidence is slowly accumulating that microenviron- mental factors must also ...
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Oncogenic Role of Epstein-Barr Virus-Encoded RNAs in Burkitt’s Lymphoma Cell Line Akata
... More interestingly, how could EBERs (RNAs) contribute to malignant phenotypes and apoptosis resistance? EBERs were reported to bind to some cellular proteins, La (16), EAP/L22 (31, 32), and PKR (6). Above ...
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Bortezomib-resistance is associated with increased levels of proteasome subunits and apoptosis-avoidance
... with apoptosis resistance ...of apoptosis is because of its ability to degrade the regulatory molecules involved in ...in apoptosis [5, 6, ...of apoptosis in many types of tumor ...
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Increased resistance to apoptosis during differentiation and syncytialization of BeWo choriocarcinoma cells
... in apoptosis- related proteins and an apparent increased resistance to induced ...specific apoptosis-related proteins and ...of apoptosis-related proteins to multinuclear or mononuclear cells ...
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Autophagy and multidrug resistance in cancer
... Complex and controversial evidence indicating a role of autophagy in tumorigenesis has emerged in recent years. Autophagy can play a protective role against cancer by eliminating damaged organelles and recycling degrada- ...
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Overexpression of OCT4 is associated with gefitinib resistance in non-small cell lung cancer
... NSCLC is the primary factor of cancer mortality around the world. Hence, there is a pressing need of novel therapeutic strategies due to their relative insensitivity to chemotherapy [11]. The high incidence of EGFR ...
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Human GM3 Synthase Attenuates Taxol Triggered Apoptosis Associated with Downregulation of Caspase 3 in Ovarian Cancer Cells
... Figure 1. Taxol-induced apoptosis and GM3 synthase ex- pression in SKOV3 cells. (a) Cells were treated with 100 nM Taxol for 48 h, harvested, and apoptosis was determined by FACS analysis as described in ...
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Myofibroblasts and their resistance to apoptosis: a possible mechanism of osteoradionecrosis
... Abstract: Osteoradionecrosis (ORN) in the head and neck area is the most devastating long-term complication of radiotherapy, with slow progression and inability to heal spontaneously. ORN can lead to intolerable pain, ...
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Original Article MicroRNA-375 confers cisplatin resistance by regulating KRAS expression in non-small cell lung cancer cell
... inhibited apoptosis, enhanced cell proliferation and increased the resistance of tumor cells to cisplatin in NSCLC H1975 ...cisplatin resistance of ...
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Phosphorylation of apoptosis repressor with caspase recruitment domain by protein kinase CK2 contributes to chemotherapy resistance by inhibiting doxorubicin induced apoptosis
... suppressed neuroblastoma growth than treatment with DOX alone [42]. There are results also demonstrate that combination of CK2 inhibitor CX4945 with erlotinib (EGFR tyrosine kinase inhibitor) results in synergistic ...
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In vitro characterisation of the neutrophil in respiratory syncytial virus bronchiolitis
... If cord blood neutrophil responses lack maturity when compared to those from a 2-week-old infant, why in this study do they appear to have responded similarly to adult neutrophils? It could be that the use of GM-CSF has ...
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Comparison of protein expression patterns between hepatocellular carcinoma cell lines and a hepatoblastoma cell line
... have been implicated in the regulation of exo- cytic and endocytic pathways. Expression of annexin II was demonstrated in HCC and was not detected in normal liver extracts (73). Both laminin receptor and annexin II are ...
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IKKγ-Mimetic Peptides Block the Resistance to Apoptosis Associated with Kaposi's Sarcoma-Associated Herpesvirus Infection
... ks-vFLIP-induced resistance to apoptosis, we next investigated whether the ks-vFLIP–IKK ␥ interaction, shown to be essential, could be successfully disrupted by mimetic peptides in ...
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Toxoplasma gondii Inhibits Apoptosis in Infected Cells by Caspase Inactivation and NF κB Activation
... inhibit apoptosis by preventing the release of cytochrome c; however, the mechanism by which parasites utilize this method of apoptotic inhibition has not been ...cell apoptosis may also provide an ...
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