Apoptotic Effect
Original Article Apoptotic effect of mtrix metalloproteinases 9 in the development of diabetic retinopathy
... tion [15]. Besides, Madsen-Bouterse et al. demonstrated that inhibition of MMP-9 could prevent the continuation of the vicious cycle of mitochondrial damage and ultimately inhibited the of DR [16]. In our study, the ...
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Original Article Transferrin receptor monoclonal antibody exacerbates curcumin-mediated apoptotic effect in castration resistant prostate cancer cells
... antitumor effect of many che- motherapeutic ...the apoptotic effect of curcumin. At apoptotic inducing concentration, curcumin evaluates the expression of TfR1 and IRP1, but inhibits AKT ...
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ROSEMARY EXTRACT ATTENUATES APOPTOTIC EFFECT OF ASPARTAME IN LIVER OF MALE RATS
... the apoptotic effect of aspartame is due to increased formation of formaldehyde which is produced by the oxidation of ...the apoptotic induction of aspartame is mainly due to its action as a stressor ...
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Anti-apoptotic effect of dexamethasone in an ototoxicity model
... assay. TUNEL-positive cells (green fluorescence follow- ing counterstaining with Myosin 7a) were clearly de- creased at higher doses of DEX, especially for hair cells (Fig. 3A). DEX pretreatment inhibited GM-induced ...
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Cordycepin enhances cisplatin apoptotic effect through caspase/MAPK pathways in human head and neck tumor cells
... greater effect of phosphorylated-JNK, phosphorylated-ERK, and phosphorylated-p38 protein expressions could be observed by cordycepin plus cisplatin (300 µ M) among the OC-3, OEC-M1, and FaDu ...
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Original Article Intermittent hypoxia induced the renal mitochondria-dependent apoptotic signals in rats
... The effect of tempol on IH-induced renal apop- tosis remains to be clarified ...IH-induced apoptotic effect in the rat kidney, since IH was associated with increased oxidative stress ...the ...
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Combined SFK/MEK inhibition prevents metastatic outgrowth of dormant tumor cells
... enhanced apoptotic effect of the combination treatment was also observed in the spontaneous out- break of other cancer cell lines, including K7M2 and the highly metastatic 4T1 BC cells upon their ...
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... little effect on apoptosis, together they induced significant apoptosis and curcumin enhances the apoptotic effect of TRAIL in dose and time dependent manner ...
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Upregulation of heme oxygenase-1 expression by curcumin conferring protection from hydrogen peroxide-induced apoptosis in H9c2 cardiomyoblasts
... data suggested that the anti-apoptotic effect of curcumin was probably attributed not only to the involvement of HO-1 but also to other elements. In addition, inhibition of PI3K/Akt pathway did not entirely ...
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The effect of antagonizing RGD-binding integrin activity in papillary thyroid cancer cell lines
... antitumor effect of antagonizing Arg-Gly-Asp (RGD)-binding integrin activity in several PTC cell ...inhibitory effect on cell viability of K1 and BCPAP cells, while the inhibitory effect was more ...
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EZH2 is increased in paediatric T-cell acute lymphoblastic leukemia and is a suitable molecular target in combination treatment approaches
... dependent on combination with other drugs. An inter- esting epigenetic agent that has the potential to increase anti-leukemic action of Daunoblastine could be DZNep. DZNep was first studied to enlarge the antiviral drugs ...
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Evaluation of Apoptotic and Antileishmanial Activities of Artemisinin on Promastigotes and BALB/C Mice Infected with Leishmania major.
... All of in vitro results were shown that this artemisinin had antileishmanial effects. Arte- misinin showed high toxicity and apoptotic effect on promasigotes and low toxicity and apoptotic ...
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<p>LncRNA-ATB Promotes the Tumorigenesis of Ovarian Cancer via Targeting miR-204-3p</p>
... the apoptotic effect of lncRNA-ATB silencing on ovarian cancer ...the apoptotic effect of lncRNA-ATB knockdown on ovarian cancer cells was reversed by the upregulation of NID1 (Figure 5C, E ...
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<p>Salvianolic acid A attenuates CCl<sub>4</sub>-induced liver fibrosis by regulating the PI3K/AKT/mTOR, Bcl-2/Bax and caspase-3/cleaved caspase-3 signaling pathways</p>
... Furthermore, in order to further understand the path- ways of the anti-apoptotic effect of SA-A in liver fi brosis, the western blot analysis and immunohistochemistry tech- niques were us[r] ...
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Protective effect of quercetin in lps induced mitochondrial cell injury
... Images a, b, c, demonstrate the protective effects of Quercetin on apoptotic effect of LPS on H9C2 for 6 hours and images d, e, f shows the repaired effect of Quercetin on H9C2 cells apo[r] ...
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Inhibition of c Jun N terminal kinase (JNK) suppresses porcine oocyte ageing in vitro
... The lower ratio of parthenogenetically activated oocytes may also be influenced by the function of ER affected by oxidation stress. Suppression of ER stress improves the embryonic development of porcine oocytes, due to a ...
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<p>Photoluminescent And Self-Assembled Hyaluronic Acid-Zinc Oxide-Ginsenoside Rh2 Nanoparticles And Their Potential Caspase-9 Apoptotic Mechanism Towards Cancer Cell Lines</p>
... therapeutic effect agents that may elevate their capacities as effective anticancer ...potential effect of Rh2HAZnO nanoparticles to induce apoptotic-medicated cell death by damaging the nucleus and ...
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The challenge to verify ceramide's role of apoptosis induction in human cardiomyocytes - a pilot study
... In the present study our first goal was to apply ceramide to evaluate the proapoptotic potential during cardiople- gia and reperfusion [9,16] in an ex vivo setting with human cardiomyocytes which to our current knowledge ...
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Lipoic acid decreases Mcl-1, Bcl-xL and up regulates Bim on ovarian carcinoma cells leading to cell death
... Many cancer cells preferentially enhance aerobic gly- colysis and transform a significant part of glucose in lac- tate, even in the presence of oxygen, a common feature of tumor growth described as the Warburg ...
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The antitumor effect of sulforaphane on Ehrlich solid mass tumor is associated with a reduction in the expression of plectin protein and oxidative stress
... the effect of Sul and other cabbage phytochemicals on the standard apoptotic pathways and showed activation of p53, p21, Bax, caspase 3 , and downregulation of Bcl2 in a large variety of cancer cells ( ...
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