The Application of Physiologically Based Pharmacokinetic
Application of physiologically based pharmacokinetic modeling in predicting drug–drug interactions for sarpogrelate hydrochloride in humans
... Here, we developed a PBPK model that linked sar- pogrelate hydrochloride to its active metabolite M-1 for simulating the DDIs of sarpogrelate with the clinically relevant CYP2D6 substrates, metoprolol, desipramine, dex- ...
14
Physiologically based pharmacokinetic modelling of antimalarial agents
... of physiologically based pharmacokinetic (PBPK) modelling in antimalarial drug research is ...the application of PBPK modelling has significant advantages towards improving clinical ...
288
A physiologically based pharmacokinetic model for ionic silver and silver nanoparticles
... of application is in the electrical and electronic industry, followed by silver brazing and ...its application as an effective antibiotic agent in various ...
18
Simulation of the Physiologically-Based Pharmacokinetic Distribution and Retention of Uranium in Rats
... 1 CHAPTER I INTRODUCTION The application of radiation and its effects has become a benefit to many, from the medical field to the industrial field. These benefits have also become a burden due to the risks that ...
82
Physiologically based pharmacokinetic (PBPK) modeling of benzene in humans: a Bayesian approach
... in pharmacokinetic parameters across the ...Comprehensive application of PBPK models to these data requires that both levels of inquiry, individual and population, be addressed--not only to elucidate ...
33
Physiologically based pharmacokinetic modeling of PLGA nanoparticles with varied mPEG content
... It also needs to be noted that any models have limitations in application. The property–biodistribution relationships developed in this study were based on the specific properties for these PLGA and ...
12
Physiologically-based pharmacokinetic modelling of infant exposure to efavirenz through breastfeeding
... However, a number of limitations are identifiable in this model. First, the lack of milk-to-plasma ratio prediction component means that only hypothetical best- and worse-case scenarios can be predicted for drugs with no ...
17
PKQuest Java: free, interactive physiologically based pharmacokinetic software package and tutorial
... important application of PBPK modeling is in the area of toxicokinetics and environmental risk assess- ment where it is essential to simulate local tissue concen- trations under varying exposure conditions ...
6
Physiologically based pharmacokinetic modeling of zinc oxide nanoparticles and zinc nitrate in mice
... International Journal of Nanomedicine Publish your work in this journal Submit your manuscript here: http://www.dovepress.com/international-journal-of-nanomedicine-journal The International Journal of Nanomedicine is an ...
16
Review. Complex drug interactions; renal impairment; physiologically-based pharmacokinetic modeling (PBPK) Key words:
... Discussion A complex DDI scenario exists when several different factors (e.g. renal impairment, hepatic impairment, metabolic enzyme inhibition, etc.) are considered, each alone does not cause a clini- cally relevant ...
12
Development of a Region-Specific Physiologically Based Pharmacokinetic Brain Model to Assess Hippocampus and Frontal Cortex Pharmacokinetics
... the application of quantitative proteomics [ 70 , 71 ...the application of this approach to the prediction of Kp uubrain (for whole brain) for 11 active transporter substrates using a similar CNS PBPK [ 28 ...
18
Using physiologically based pharmacokinetic modeling and benchmark dose methods to derive an occupational exposure limit for N-methylpyrrolidone
... uncertainty), and visual inspection. 2.2.4. Point of departure (POD)/human equivalent concentration (HEC) calculation The selection of an appropriate benchmark response rate for skeletal malformations needs to take into ...
11
Physiologically-based pharmacokinetic and toxicokinetic models for estimating human exposure to five toxic elements through oral ingestion
... and physiologically-based pharmacokinetic (PBPK) modelling are useful complementary tools in quantifying human exposure to elements in the ...and application, given the di fferences in ...
11
A comprehensive framework for physiologically based pharmacokinetic modelling in Matlab.
... and pharmacokinetic data describe the information related to physicochemical properties ...laboratory- based experiments that are then scaled to the in vivo clearance under the consideration of system ...
16
Physiologically Based Pharmacokinetic Models for the Systemic Transport of Trichloroethylene
... In Chapter 3 we adapt the dispersion model of Roberts and Rowland to describe the transport of TCE in adipose tissue. The geometry and fundamental assump- tions for the model are based specifically on the ...
248
A physiologically based pharmacokinetic (PBPK) model of vitamin D
... PBPK model, this study was able to fit serum concentration data for circulating.. 21.[r] ...
26
Applications of Physiologically Based Pharmacokinetic Models in Veterinary Medicine.
... Table 2.1 Published pharmacokinetic values for Sulfamethazine in swine after intravenous and oral dosing .........................................................................................28 Table 3.1 Organ ...
166
PHYSIOLOGICALLY BASED PHARMACOKINETIC MODEL FOR PLANT BASED ANTI OXIDANT DRUGS
... Ayanavaram, Chennai, Tamil Nadu, India. Email: [email protected] Received: 14 July 2016, Revised and Accepted: 06 September 2016 ABSTRACT Objective: A pharmacokinetic study is a cumbersome process in ...
7
Physiologically based pharmacokinetic models for the transport of trichloroethylene in adipose tissue
... ëÑèêfàÑñDÜàÑPä ÏÜèàÔÓeÒQÕÑ ÒâÜ!ÏÏÒQÓQèèåeÓ:åOñâ)ÕÑÓ-ÏQëyìßÐLÏ#ÐÏEÕxÏ5Ô)ÕÑ8äÕâä ÕÏÏàåeçÔÐÜ!ÑWà8ÏÓ:ä ÐÑvçßêÏÐÜèÜéÐLÒQÕè. å2ÜäÓ:èÐÑéPë[r] ...
27
Applications of physiologically based pharmacokinetic modeling for the optimization of anti-infective therapies
... physiologically based pharmacokinetic (PBPK) modeling: physiological data for healthy and health- 724. impaired elderly[r] ...
41