apurinic/apyrimidinic
Mutation in P0, a Dual Function Ribosomal Protein/Apurinic/Apyrimidinic Endonuclease, Modifies Gene Expression and Position Effect Variegation in Drosophila
... In a search for modifiers of gene expression with the white eye color gene as a target, a third chromosomal P-element insertion mutant l(3)01544 has been identified that exhibits a strong pigment increase in a ...
9
Sequential treatment with AT-101 enhances cisplatin chemosensitivity in human non-small cell lung cancer cells through inhibition of apurinic/apyrimidinic endonuclease 1-activated IL-6/STAT3 signaling pathway
... Notes: (A) The average weight of mice; (B) the photo of xenograft tumors for four groups; (C) the volume of tumors in aT-101 plus cDDP was smaller than that in control, aT-101 alone, or cDDP alone (P 0.05); (D) the ...
13
Functional analysis of tanshinone IIA that blocks the redox function of human apurinic/apyrimidinic endonuclease 1/redox factor-1
... Abstract: Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) is a multifunctional protein possessing both DNA repair and redox regulatory ...
14
Activation of GLP-1 Receptor Enhances Neuronal Base Excision Repair via PI3K-AKT-Induced Expression of Apurinic/Apyrimidinic Endonuclease 1
... (ligase). Apurinic/apyrimidinic endonuclease 1 (APE1), the most abundant apurinic endonuclease in human cells [11], incises the sugar phosphate backbone at the abasic site generating a one-nucleotide ...
13
African Swine Fever Virus Protein pE296R Is a DNA Repair Apurinic/Apyrimidinic Endonuclease Required for Virus Growth in Swine Macrophages
... Base excision repair (BER) is the major system for the repair of DNA base lesions such as the products of deamina- tion, oxidation, and alkylation, all of which can arise endog- enously (22). As such, BER plays an ...
11
Evidence that the UV endonuclease activity induced by bacteriophage T4 contains both pyrimidine dimer-DNA glycosylase and apyrimidinic/apurinic endonuclease activities in the enzyme molecule.
... 204-210 0022-538X/81/100204-07$02.00/0 Evidence that the UV Endonuclease Activity Induced by Bacteriophage T4 Contains Both Pyrimidine Dimer-DNA Glycosylase and Apyrimidinic/Apurinic End[r] ...
7
Targeting human apurinic/apyrimidinic endonuclease 1 (APE1) in phosphatase and tensin homolog (PTEN) deficient melanoma cells for personalized therapy.
... RA designed the work, acquired data, played an important role in interpreting the results, drafted the manuscript and approved the final version; RJ acquired human melanoma data, played [r] ...
14
A Non-Long Terminal Repeat Retrotransposon Family Is Restricted to the Germ Line Micronucleus of the Ciliated Protozoan Tetrahymena thermophila
... The ciliated protozoan Tetrahymena thermophila undergoes extensive programmed DNA rearrangements during the development of a somatic macronucleus from the germ line micronucleus in its sexual cycle. To investigate the ...
13
Oligo swapping method for in vitro DNA repair substrate containing a single DNA lesion at a specific site
... 6 – 4 pp.: pyrimidine (6 – 4) pyrimidone photoproduct; 8-oxoG: 8- oxoguanine; AP: Apurinic/apyrimidinic site; APE1: Apurinic/apyrimidinic endonuclease; BER: Base excision repair; CPD: Ci[r] ...
9
The mode-of-action of the carcinogen chromium (VI): An investigation into the formation of DNA lesions during the reduction of chromate
... Evidence for the formation of alkaline labile sites was obtained from alkaline elution studies using cultured mammalian cells exposed to chromate. Christie et a l (1984) and Cantoni and Costa, (1984) observed that D NA ...
158
Small-molecule BH3 mimetic and pan-Bcl-2 inhibitor AT-101 enhances the antitumor efficacy of cisplatin through inhibition of APE1 repair and redox activity in non-small-cell lung cancer
... aPe1, apurinic/apyrimidinic endonuclease 1; aP-1, activator protein 1; aTF1, activating transcription factor 1; Bcl-2, B-cell lymphoma 2; Ber, base excision repair; cDDP, cisplatin; creB, caMP response ...
24
Programming of Cell Resistance to Genotoxic and Oxidative Stress
... repair gene increases resistance to ultraviolet radiation in human cells by selective repair of DNA damage. Expression of yeast but not human apurinic/apyrimidinic endonuclease 458[r] ...
25
Investigation of the transcriptional response of Sulfolobus solfataricus to damaging agents
... Table 6.8 Microarray data showing genes down regulated in the knockout compared to the wild type after Hydrogen peroxide damage... Apurinic or apyrimidinic site.[r] ...
223
The role of ascorbate in the activation of chromium(V) to its ultimate carcinogenic form
... alkali (Shaaper and Loeb, 1981; Kunkel et a l, 1981) or with an AP-endonuclease (Shaaper et a l, 1983; Kunkel et a l 1983), treatments known to cleave DNA at AP- sites (Loeb and Preston, 1986). Furthermore, the mutagenic ...
171
Familial adenomatous polyposis
... APE1: apurinic endonucle- ase 1; BER: base excision repair; CE: capsule endoscopy; CHRPE: congenital hypertrophy of the retinal pigment epithelium; CIN: chromosomal instability; CRC: colorec- tal cancer; CSGE: ...
23
den V gene of bacteriophage T4 codes for both pyrimidine dimer-DNA glycosylase and apyrimidinic endonuclease activities.
... 1 denV Gene of Bacteriophage T4 Codes for Both Pyrimidine Dimer-DNA Glycosylase and Apyrimidinic Endonuclease Activities Received 7 April 1981/Accepted 10 June 1981 Recent studies have s[r] ...
13
Genetics of amyotrophic lateral sclerosis: an update
... A ’ D: Alzheimer ’ s disease; AD: Autosomal dominant; ALS: Amyotrophic lateral sclerosis; ANG: Angiogenin; AOA2: Ataxia Ocular Apraxia 2; APEX1: Apurinic Endonuclease DNA repair enzyme 1; AR: Autosomal ...
15
Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells
... 53BP1: p53-binding protein; 5-FU: 5-fluorouracil; 6-PDSA: 6-pentadecyl salicylic acid; allyl-ITC: allyl isothiocyanate; AM: allyl mercaptan; AMS: allyl methyl sulfide; APE1: apurinic/apy[r] ...
23
<p>Berzosertib (VE-822) inhibits gastric cancer cell proliferation via base excision repair system</p>
... AP, apurinic or apyrimidi- nic; APE, AP-endonuclease; APOBEC3B, apolipoprotein B mRNA-editing enzyme catalytic subunit 3B; ATCC, American type culture collection; BER, base excision repair; CI, con fi dence ...
15