Aristolochic Acid
Effect of Ochratoxin A and Aristolochic Acid on a Porcine Kidney Cell Line
... The Balkan endemic nephropathy (BEN) is an irreversible, chronic, tubulo-interstitial nephropathy described so far in several rural regions from the Balkan with an unknown aetiology. Both ochratoxin A (OTA) and ...
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Molecular electrostatic potential, HOMO-LUMO and vibrational study of aristolochic acid II using density functional theory
... In this communication, we have presented molecular electrostatic potential surface (MEP), highest occupied molecular orbitals (HOMO)- lowest unoccupied molecular orbital (LUMO), and the vibrational spectra of the ...
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Prescription profile of potentially aristolochic acid containing Chinese herbal products: an analysis of National Health Insurance data in Taiwan between 1997 and 2003
... of aristolochic acid (AA) was subsequently corroborated by clinical reports [3-9], results from animal models [10-12] and the detection of AA bound DNA adducts in kidney and ureteral tissues ...
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Is aristolochic acid nephropathy a widespread problem in developing countries? A case study of Aristolochia indica L in Bangladesh using an ethnobotanical phytochemical approach
... cause aristolochic acid nephropathy (AAN), a renal interstitial fi brosis, which is associated with a high incidence of upper urinary tract cancer (UUC) (Nortier et ...
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Premalignant alteration assessment in liver-like tissue derived from embryonic stem cells by aristolochic acid I exposure
... The in vitro predictive evaluation of chemical carcinogenicity based on hepatic premalignance has so far not been established. Here, we report a novel approach to investigate the premalignant events triggered by human ...
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Aristolochic acid containing herbs induce gender-related oncological differences in upper tract urothelial carcinoma patients
... A total of 687 patients pathologically diagnosed with UTUC were enrolled in our study. The majority of patients were female (55.5%). When patients were grouped according to gender, several significant differences emerged ...
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NBO, chemical reactivity, thermodynamic properties and hyperpolarizability analysis of aristolochic acid II
... In the present work the chemical reactivity descriptors, thermodynamic properties and the natural bond orbitals (NBOs) analysis of an alkaloid aristolochic acid II have been communicated. The aim of this ...
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Smad7 protects against chronic aristolochic acid nephropathy in mice
... Aristolochic acid nephropathy (AAN) is initially called Chinese-herb nephropathy before aristolochic acid (AA) is known as a cause of AAN [1, ...
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Ultrasonication Extraction and Solid Phase Extraction Clean-up for Quantification of Aristolochic acid I in the Thai Herbal Antitussive 3 Formula by High Performance Liquid Chromatography with Photodiode Array Detection
... based on ATF3. First, all sample powders were extracted twice by mixing with 1% ammonia in MeOH over 10 minutes. Supernatants were separated from precipitates by centrifugation at 6,500 rpm for 10 minutes at 25˚C. One ...
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Mutation signatures implicate aristolochic acid in bladder cancer development
... Although one bladder tumor from Singapore and three bladder tumors from China showed patterns of A:T > T:A mutations that were very similar to those in tumors with known AA exposure ([r] ...
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Human liver-kidney model elucidates the mechanisms of aristolochic acid nephrotoxicity
... Aristolochic acids (AA), produced by plants of the Aristolochiaceae family, have been used worldwide for medicinal purposes for more than 2,500 years, and this practice is still common in many cultures today. AA ...
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Role of hepatic cytochrome P450 enzymes in the detoxication of aristolochic acid I; effects on DNA adduct, mutation, and tumor formation
... As several studies indicate, metabolism of AAI plays a very important role in the initiation and progress of aris- tolochic acid nephropathy (AAN) and Balkan endemic nephropathy (BEN) [19, 26 – 29]. Understanding ...
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Impact of aristolochic acid exposure on oncologic outcomes of upper tract urothelial carcinoma after radical nephroureterectomy
... To the best of our knowledge, this is the first study inves- tigating the association between AA exposure history and oncologic outcomes of UTUC in a large Chinese cohort, with[r] ...
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Detection Aristolochic Acids 1 and 2 in Costustoot via Electrochemical Method and Liquid Chromatography
... Aristolochic acid 1 (AA-1), aristolochic acid 2 (AA-2), 3,5-di-tert-butyl-1,2-benzoquinone and methanol were purchased from Sigma Aldrich ...
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KINETICS AND MECHANISM OF OXIDATION OF MIXTURE OF DL-MALIC ACID AND L (+) TARTARIC ACID BY CHROMIC ACID IN PRESENCE OF HYDROCHLORIC ACID AND SODIUM CHLORIDE
... Hydrochloric Acid, hence the reaction is ...Chromic Acid and Hydrogen ion ...Hydrochloric Acid in the ...Hydrochloric Acid (Fig ...Hydrochloric Acid is due to positive catalysis which ...
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OXIDATION OF LACTIC ACID BY CHROMIC ACID IN PRESENCE OF MODERATELY STRONG ACID; A KINETIC AND MECHANISTIC STUDY
... Lactic Acid by Chromic Acid reaction, all reactants were mixed in equimolar ...Glycolic Acid react with Chromic Acid to form an intermediate ...Pyruvic Acid (α- keto acid) ...
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Kinetics and Mechanism of Oxidation of Phenyl Acetic Acid and Dl-Mandelic Acid by Permanganate in Acid Medium
... mandelic acid in case of Phenyl acetic acid and ester formation with Mn (VII) in case of DL-Mandelic ...DL-Mandelic acid > Phenyl acetic ...DL-Mandelic acid over phenyl acetic acid ...
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KINETICS AND MECHANISM OF OXIDATION OF L-ASCORBIC ACID BY CHROMIC ACID IN PRESENCE OF HYDROCHLORIC ACID
... L-Ascorbic Acid by Chromic Acid in presence of Hydrochloric Acid under first order conditions by keeping the concentration of L-Ascorbic Acid at least twenty four times in excess over Chromic ...
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KINETICS AND MECHANISM OF OXIDATION OF L- ASCORBIC ACID BY CHROMIC ACID IN PRESENCE OF SULPHURIC ACID
... respect to Hydrogen ion concentration as shown in Fig No 02. The order of reaction with respect to oxidant is one and also one with respect to substrate. Total order of the oxidation reaction is two. The pH value of the ...
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Acid-Base_Titration_Lab.pdf
... You will use a computer to monitor pH as you titrate. The region of most rapid pH change will then be used to determine the equivalence point. The volume of NaOH titrant used at the equivalence point will be used to ...
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