Array Comparative Genomic Hybridization
Array Comparative Genomic Hybridization as a Diagnostic Tool in Cancer
... Array comparative genomic hybridization (aCGH) is a specific molecular cy- togenetic method that combines CGH and DNA microarrays and enables whole molecular cytogenetic ...blinded ...
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Genomic profiling using array comparative genomic hybridization define distinct subtypes of diffuse large b-cell lymphoma: a review of the literature
... resolution array comparative genomic hybridization (aCGH) have revealed recurrent copy number alterations (CNA), as well as prognostic indicators in a number of DLBCL subtypes [22-27], for ...
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Prenatal diagnosis of a de novo interstitial deletion of 11q (11q22.3 → q23.3) associated with abnormal ultrasound findings by array comparative genomic hybridization
... resolution. Array CGH using Agi- lent’s 8 × 60 K commercial arrays (Agilent Technologies, Santa Clara, CA, USA) was performed on DNA ex- tracted from uncultured cord blood and a ...
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Chromosomal Aberrations in ETV6/RUNX1-positive Childhood Acute Lymphoblastic Leukemia using 244K Oligonucleotide Array Comparative Genomic Hybridization
... Based on our FISH study on five childhood ALL patients, all samples showed a positive ETV6/RUNX1 fusion signal. Three patients (nos. 1, 3 and 5) showed concordant result with array CGH for ETV6 gene deletion. FISH ...
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Establishment of a new human osteosarcoma cell line, UTOS-1: cytogenetic characterization by array comparative genomic hybridization
... The cytogenetic characteristics of osteosarcoma (OS) remain controversial. The establishment of a new human OS cell line may improve the characterization. We report the establishment of a new human osteosarcoma cell ...
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Array comparative genomic hybridization of 18 pancreatic ductal adenocarcinomas and their autologous metastases
... Before array CGH was performed, DNA was RNase (RNase, DNase free, Roche, USA) treated and purified a second time before labeling using Kreatech’s (Kreatech Diagnostics, Amsterdam, Netherlands) non-enzymatic ...
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Well differentiated angiosarcoma of spleen: a teaching case mimicking hemagioma and cytogenetic analysis with array comparative genomic hybridization
... aCGH: array comparative genome hybridization; CT: computed tomography; AST: aspartate aminotransferase; DAVID: database for annotation, visualization and integrated discovery; LOH: loss of ...
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Prenatal diagnosis of Wolf-Hirschhorn syndrome confirmed by comparative genomic hybridization array: report of two cases and review of the literature
... as array comparative genomic hybridization (a-CGH) increased the detection rate of submicroscopic chromo- somal aberrations that could also lead to a WHS pheno- ...
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Implementation of a genomic medicine multi-disciplinary team approach for rare disease in the clinical setting: a prospective exome sequencing case series
... involved array comparative genomic hybridization (aCGH) testing (pre- dominantly cases involving learning difficulties and neurological phenotypes) and single gene(s) sequencing (in 53% and ...
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Array-CGH characterization and genotype-phenotype analysis in a patient with a ring chromosome 6
... Array-Comparative Genomic Hybridization (Array-CGH) The array-Comparative Genomic Hybridization (aCGH) study was performed using the Agilent Human Genome CGH ...
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A 18p11.23-p11.31 microduplication in a boy with psychomotor delay, cerebellar vermis hypoplasia, chorioretinal coloboma, deafness and GH deficiency
... through array comparative genomic hybridization (aCGH), not overlapping with the previously described one, encompassing three genes, namely ARHGAP28 , LINC00668 and LAMA1 in a 10 year-old boy ...
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Application of next-generation sequencing for 24-chromosome aneuploidy screening of human preimplantation embryos
... ing array comparative genomic hybridization (aCGH) [15], single-nucleotide polymorphism microarrays (SNP) [16], and quantitative polymerase chain reaction (Q-PCR) ...[17]. Array CGH was ...
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Molecular cytogenetic characterization of undifferentiated embryonal sarcoma of the liver: a case report and literature review
... our array comparative genomic hybridization (aCGH), fluorescence in situ hybridization (FISH) findings, and a missense mutation of TP53 gene by DNA sequencing in a 19-year-old patient ...
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Preimplantation genetic diagnosis guided by single-cell genomics
... microarray comparative genomic hybridization and analysis, SNP-array analysis or massively parallel sequence ...aCGH, array comparative genomic hybridization; BAF, ...
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Role of Copy Number Variants in Structural Birth Defects
... variation, array comparative genomic hybridization, birth defects, craniofacial defects, respiratory defects, renal defects, and congenital heart ...
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13q mosaic deletion including RB1 associated to mild phenotype and no cancer outcome – case report and review of the literature
... hands). Array Comparative Genomic Hybridization on blood identified a mosaic ...Situ Hybridization (iFISH) on both blood genomic DNA and cultured/uncultured blood lymphocytes, ...
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Application of Array Based Comparative Genomic Hybridization to Pediatric Neurologic Diseases
... Purpose: Array comparative genomic hybridization (array-CGH) is a technique used to analyze quantitative increase or decrease of chromosomes by competitive DNA hybridization of ...
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A microdeletion in the GRHL2 Gene in two unrelated patients with congenital fibrosis of the extra ocular muscles
... high-resolution array comparative genomic hybridization (arrayCGH) has the ability to detect small and potentially sympto- matic CNVs into the range of 1 ...
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Yield of comparative genomic hybridization microarray in pediatric neurology practice
... Array comparative genomic hybridization (aCGH) is a ge- netic technology used to identify copy number variants (CNVs). A CNV is a duplicated or deleted segment of DNA, greater than 1 kb in ...
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Copy number variants in a sample of patients with psychotic disorders: is standard screening relevant for actual clinical practice?
... genome-wide array comparative genomic hybridization, studies on the putative genetic etiology of schizophrenia have focused on the detection of copy number variants (CNVs), ie, microdeletions ...
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