artemether-lumefantrine
Therapeutic efficacy of artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Ethiopia: a systematic review and meta-analysis
... Early diagnosis and timely treatment of malaria with an effective drug is an important strategy to control the disease [7]. However, the emergence of antimalarial drug resistance is one of the challenges towards ...
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Surveillance of the efficacy of artemether lumefantrine and artesunate amodiaquine for the treatment of uncomplicated Plasmodium falciparum among children under five in Togo, 2005 2009
... of artemether-lumefantrine was high and did not change between 2005 and 2009, despite the absence of co-administration of ...of lumefantrine [7]. In 2009, artemether-lumefantrine was ...
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Esu, Ekpereonne Babatunde (2017): The effectiveness of intermittent screening and treatment with artemether-lumefantrine for malaria prevention in pregnancy in South East Nigeria. Dissertation, LMU München: Medizinische Fakultät
... drug artemether-lumefantrine is a fixed combination of artemether-lumefantrine in the ratio 1(20mg, artemether): 6 (120mg, ...groups. Artemether is a sesquiterpene lactone ...
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Gametocyte clearance in children, from western Kenya, with uncomplicated Plasmodium falciparum malaria after artemether–lumefantrine or dihydroartemisinin–piperaquine treatment
... Kenya, artemether–lumefantrine (AL) and dihydroar- temisinin–piperaquine phosphate (DP) were officially implemented in 2006 as the first-line and second-line drug, respectively, for management of ...
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Pharmacokinetics of artemether and dihydroartemisinin in healthy Pakistani male volunteers treated with artemether lumefantrine
... metabolism. Artemether is metabolized to its active metabolite dihydroartemisinin by the enzymes CYP1A2, CYP2B6 and CYP3A4 in humans ...of artemether into dihydroartemisi- ...of artemether should ...
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Assessment of the therapeutic efficacy of artemether lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in northern KwaZulu Natal: an observational cohort study
... [3]. Artemether-lumefantrine (AL) has been first-line treat- ment of uncomplicated Plasmodium falciparum malaria in northern KwaZulu-Natal since it was introduced in response to these drug-resistant ...
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Open-label trial on efficacy of artemether/lumefantrine against the uncomplicated <em>Plasmodium falciparum</em> malaria in Metema district, Northwestern Ethiopia
... Purpose: Following the increased Plasmodium falciparum resistance to chloroquine and sulfadoxine/pyrimethamine, Ethiopia adopted artemether/lumefantrine (AL) as the first-line treatment for uncomplicated P. ...
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DRUG USE EVALUATION OF ARTEMETHER-LUMEFANTRINE (COARTEM®) FOR FALCIPARUM MALARIA IN KARA MARA HOSPITAL, JI-JIGA TOWN, FAFAN ZONE, EASTERN ETHIOPIA
... containing artemether-lumefantrine replaced sulphadoxine/ pyrimethamine as the first-line drug for treatment of uncomplicated malaria in developing countries including Ethiopia due to the development and ...
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DEVELOPMENT AND VALIDATION OF ARTEMETHER & LUMEFANTRINE IN PHARMACEUTICAL DOSAGE FORMS
... The developed method was validated for parameters such as System suitability, Precision, Accuracy, Linearity and Robustness for the assay of Artemether + Lumefantrine. Hence the method is suitable, linear, ...
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A systematic review of the safety and efficacy of artemether lumefantrine against uncomplicated Plasmodium falciparum malaria during pregnancy
... of artemether-lumefantrine (AL) in ...of artemether or AL exposure in pregnancy, including randomized clinical trials, observational studies and systematic ...
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Randomized trials of artemisinin piperaquine, dihydroartemisinin piperaquine phosphate and artemether lumefantrine for the treatment of multi drug resistant falciparum malaria in Cambodia Thailand border area
... [10-12]. Artemether-lumefantrine (20 mg of artemether and 120 mg of lumefantrine) is another ACT that is administered in six consecutive doses: four tablets each at 0 hours and 8 hours on the ...
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Comparative study of the efficacy and tolerability of dihydroartemisinin piperaquine trimethoprim versus artemether lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Cameroon, Ivory Coast and Senegal
... The fixed-dose ACT artemether-lumefantrine (Coar- tem ® ) remains very effective and well tolerated. It is recommended, however, that it be administered twice daily for three days with a fat-rich meal, ...
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BILAYER TABLET OF ARTEMETHER & LUMEFANTRINE TABLETS: DEVELOPMENT AND EVALUATION
... of Artemether and Lumefantrine, has consistently achieved cure rates of >95% in clinical ...of Artemether/Lumefantrine specifically designed for infants and children in all age ...
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Effect of different excipients on formulation of immediate release artemether/lumefantrine tablets
... of Artemether/Lumefantrine (20mg/120mg)were prepared in different concentrations with: Microcrystalline cellulose (as diluent), HPMC and Polyvinylpyrrolidone ( as binder), Croscarmellose sodium, ...
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Community screening and treatment of asymptomatic carriers of Plasmodium falciparum with artemether lumefantrine to reduce malaria disease burden: a modelling and simulation analysis
... Community screening and treatment of asymptomatic carriers of Plasmodium falciparum with artemether-lumefantrine to reduce malaria disease burden: a modelling and simulation analysis Ste[r] ...
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The clinical efficacy of artemether/lumefantrine (Coartem®)
... 48. Mayxay M, Khanthavong M, Lindegårdh N, Keola S, Barends M, Pongvongsa T, Yapom R, Annerberg A, Phompida S, Phetsouvanh R, White NJ, Newton PN:Randomized comparison of chloroquine plus sulfadoxine-pyrimethamine versus ...
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Efficacy of artemether lumefantrine, the nationally recommended artemisinin combination for the treatment of uncomplicated falciparum malaria, in southern Laos
... or artemether-lumefantrine, presented with intercurrent non-malarial illness or any condition, which in the judgement of the investigator would place the subject at undue risk or interfere with the results ...
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Comparison of azithromycin plus chloroquine versus artemether lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in children in Africa: a randomized, open label study
... The combination of azithromycin (AZ) and chloro- quine (CQ) has been shown to have synergistic activity in vitro and in vivo against CQ-resistant strains of P. fal- ciparum [3-5]. AZ and CQ are marketed drugs, and there ...
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A barcode of multilocus nuclear DNA identifies genetic relatedness in pre and post Artemether/Lumefantrine treated Plasmodium falciparum in Nigeria
... of artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum infections in Lagos, Nigeria and determined the prevalence of drug resistant strains in the ...
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Evaluation of two novel tablet formulations of artemether lumefantrine (Coartem®) for bioequivalence in a randomized, open label, two period study
... Background: Artemether-lumefantrine (Coartem W ; AL) is a standard of care for malaria treatment as an oral six-dose regimen, given twice daily over three days with one to four tablets (20/120 mg) per dose, ...
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