B-cell activating factor receptor
Persistent Friend Virus Replication and Disease in Apobec3-Deficient Mice Expressing Functional B-Cell-Activating Factor Receptor
... gene, B-cell-activating factor receptor ...in B-cell phenotypes: A/WySn mice contain lower B-cell numbers, a decreased percentage of B cells in the ...
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Deficiency of the B Cell-Activating Factor Receptor Results in Limited CD169+ Macrophage Function during Viral Infection
... In this study, we have identified a critical role for BAFFR in the maintenance of CD169 ⫹ macrophages. Baffr ⫺/⫺ mice showed limited innate immune activation and reduced adaptive immune FIG 7 Impaired innate and adaptive ...
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Fichtner, Miriam Franziska Laura (2018): Features of the two isoforms of TACI/TNFRSF13B in soluble and membrane-bound form. Dissertation, LMU München: Medizinische Fakultät
... (B-cell activating factor) und APRIL (A proliferation- inducing ligand) regulieren das Überleben der B-Zellen durch die Bindung an die drei Rezeptoren TACI (transmembrane activator and ...
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The clinical application of mesenchymal stromal cells in hematopoietic stem cell transplantation
... vascular cell adhesion molecule (VCAM)-1, intercellular cell adhesion molecule (ICAM)-1, and lymphocyte function-associated antigen (LFA)-3 involved in T-cell interactions, which re- sult in the ...
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NF-κB signaling and its relevance to the treatment of mantle cell lymphoma
... Activated B cell-like diffuse large B cell lymphoma; BAFF/ TNFSF13B: B cell-activating factor; BAFFR: B cell-activating factor ...
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Decorin suppresses tumor cell growth by activating the epidermal growth factor receptor
... inhibits cell growth and prevents fibrosis by blocking TGF- b activity (10, ...( b ) decorin is rarely expressed by actively proliferating or transformed cells; ( c ) decorin expression is abrogated ...
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Orphan nuclear receptor NR2F6 acts as an essential gatekeeper of Th17 CD4+ T cell effector functions
... arylhydrocarbon receptor; AICD, activation induced cell death; AP-1, activating protein-1; Bcl6, B-cell lymph- oma 6 protein; BMAL1/ARNTL, aryl hydrocarbon receptor nuclear ...
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Endoplasmic reticulum stress and apoptosis
... – activating transcription factor 6; BAP31 – B-cell receptor- associated protein 31; BiP – luminal binding protein; C/EBP – CCAAT/enhancer- binding proteins; eIF-2α – eukaryotic ...
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Dissecting Bacterial Cell Wall Entry and Signaling in Eukaryotic Cells: an Actin Dependent Pathway Parallels Platelet Activating Factor Receptor Mediated Endocytosis
... FIG 5 CW trafficking to lysosomes. (A) WT MLEC were incubated with FITC- labeled CW (green) for 2 h at 37°C, fixed with methanol, and immunostained for LAMP2 (magenta). A representative deconvolved high-magnification ...
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B cell activating factor targeted therapy and lupus
... Autoreactive B-cell receptors are generated either when random immunoglobulin variable gene rearrangement occurs in the bone marrow or as a consequence of somatic mutation that occurs mainly in the germinal ...
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Peripheral regulatory cells immunophenotyping in Primary Sjögren's Syndrome: a cross sectional study
... BAFF: B cell activating factor; BCR: B cell receptor; CpG: cytosine-phopsphate-guanosine; DC: dendritic cell; DCregs: indoleamine 2,3-dioxygenase-expressing ...
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Cullin-RING ligases in regulation of autophagy
... Ambra1: activating molecule in Beclin-1-regulated autophagy; AMPK: AMP-activated protein kinase; ATF4: activating transcription factor 4; ATG: autophagy related gene; Bcl-2: B-cell ...
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Lupus nephritis: current update
... athero genesis and coronary vascular disease are now recognized complications of SLE [128]. Recognized risk factors include hypertension, hyperlipidemia, nephrotic syn drome, prolonged corticosteroid use, anti phos- ...
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Serum BAFF and APRIL levels in patients with IgG4 related disease and their clinical significance
... of B cell maturation, survival, CD40L-independent antibody production, and isotype switching through BAFF-R and TACI ...induce B cell hyperactivation and autoimmunity in mice [28], BAFF has ...
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Immune cell subset differentiation and tissue inflammation
... immune response [81]. The third subset M2b are acti- vated when their FcγRs bind to LPS [82, 83]. M2b MØ turn off their production of IL-12 and secrete IL-10. In addition, M2b MØ upregulate antigen presentation and, ...
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Suramin, an experimental chemotherapeutic drug, activates the receptor for epidermal growth factor and promotes growth of certain malignant cells
... enhances cell surface signaling in A431 cells by activating an autocrine loop involving the receptor for epidermal growth factor ...growth factor alpha, thereby increasing its potential ...
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Rationale of anti CD19 immunotherapy: an option to target autoreactive plasma cells in autoimmunity
... targeting B cells has been approved for treatment of non-Hodgkin lymphoma, rheumatoid arthritis and anti-neutrophil cytoplasmic antibody-associated vasculitides and has led to reappreciation of B-lineage ...
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The role of death-associated protein 3 in apoptosis, anoikis and human cancer
... The processes underlying apoptosis have been impli- cated in carcinogenesis and have thus been the subject of continued research in the context of cancer. The earliest and most well − documented apoptosis gene is the ...
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Kitasato symposium 2010: new prospects for cytokines
... Gerd-Rüdiger Burmester (Berlin, Germany) considered the clinical value of blocking signalling via the granulocyte/ macrophage colony-stimulating factor (GM-CSF) path- way. GM-CSF is elevated in synovial fl uid from ...
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Immunotherapy in hematologic malignancies: past, present, and future
... T cell therapy, which is a field that is moving at an accelerated ...T cell signaling domain with a costimulatory domain (number and type depending on the specific CAR) [47, ...established cell ...
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