B Cell Development
The Interplay between Hedgehog Signalling and BMP Signalling in Regulating B cell Development
... cellular development and a novel role for morphogens in self-renewing tissues has been ...immune cell development must be ...the development of many haematopoietic cells and Sacedon et al ...
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MicroRNAs in B cell development and malignancy
... in B cell development has also been established (Figure ...early B cells led to a developmental arrest at the pro-B cell to pre-B cell transition, and also caused ...
10
Characterization of B Cell Development and Activation in the Absence of Akt or Presenilin
... deficient B cells, mainly loss of MZ and B1 B cells, and an inability to compete with wild-type progenitors in mixed marrow chimeras (Rickert, Rajewsky et ...MZ B cell numbers, and crossing ...
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Mutations in Igα (CD79a) result in a complete block in B cell development
... of B-cell development in the human correspond to those seen in the mouse; how- ever, there are subtle differences that suggest some flex- ibility in the mechanisms used to regulate various stages of ...
8
The role of Rac GTPases in B cell development and activation
... Fraction B/C pro-B cells, which is in good agreement with the expression of endogenous CD19 (Schwenk et ...Fraction B/C pro-B cells delete the allele in Racl^Rac2 '' mice, R acl protein may ...
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Immunoglobulin heavy chain expression shapes the B cell receptor repertoire in human B cell development
... In the mouse, two Igµ-mediated mechanisms account for selection against self-reactive or poorly pairing Ab’s during B cell development, receptor edit- ing and deletion (39–44). Editing makes a major ...
9
The Ig heavy chain protein but not its message controls early B cell development
... early B cell development (4, 8, ...T cell lineage, in which the TCR-β chain but not a frame-shifted message controls rearrangement and early T cell development ...the B ...
10
Checkpoints that control B cell development
... to B cells in a transient wave, which preferentially populates epithelia and lung as well as gut-associated lymphoid ...continuous B cell development throughout life in the bone marrow to ...
9
The LRF transcription factor regulates mature B cell development and the germinal center response in mice
... the development of new target therapies for autoimmune diseases and B cell ...Employing B cell–specific conditional knockout mice, we have demonstrated here that the transcription ...
17
Transcription factors of the alternative NF-κB pathway are required for germinal center B-cell development
... GC B cells cultured on CD40L-expressing fibroblasts demonstrated p100 p52 processing ...LZ B cells by immunofluorescence (IF) analysis ...LZ B cells and therefore suggests that the alternative ...
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The immunosenescence-related gene Zizimin2 is associated with early bone marrow B cell development and marginal zone B cell formation
... analyzed B and T cell development in KO ...of B or T cells in BM, the spleen, thymus, or peritoneal cavity was ...BM B cells [10], as shown in Figure 2A and ...MZ B cell ...
12
MicroRNA-132 is a Physiological Regulator of Hematopoietic Stem Cell Function and B-cell Development
... Because the expression of miR-132 was higher in HSCs compared to total bone marrow cells, we utilized both gain-of-function and loss-of-function approaches to investigate its role in HSC function and survival. Ectopic ...
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A human non XLA immunodeficiency disease characterized by blockage of B cell development at an early proB cell stage
... In the mouse, gene targeting has shed light on the sequen- tial events that drive the early steps of B cell differentiation. Most of these genes encode transcription factors which control regulatory points ...
9
CD19: a biomarker for B cell development, lymphoma diagnosis and therapy
... Recent studies have constructed one model of lympho- magenesis involving CD19 and the proto-oncogene c-Myc . A positive feedback pathway in which upregu- lated CD19 expression and phosphorylation, induced by constitutive ...
7
The Role of Morphogens in B Cell Development
... bearing B cells in the bone marrow either mature in this site or migrate to the peripheral lymphoid organs such as the ...naïve B cells leave the bone marrow as transitional B cells, where they are ...
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Gata3 restrains B cell proliferation and cooperates with p18 INK4c to repress B cell lymphomagenesis
... lymphoid cell differentiation and its function in T cell commitment and development has been extensively ...T cell specification by repressing B cell potential in pro T cells and ...
14
Regulatory mechanisms of B cell responses and the implication in B cell-related diseases
... mature B cells and plasma cells B cell differentiation is tightly controlled by a transcrip- tion regulation ...plasma cell-related genes, and downregulate the B cell identity ...
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Ibrutinib for B cell malignancies
... normal B-cell development and is also associated in the development of the most common B- cell malignancies ...and cell migra- tion ...
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Development of transplantable B-cell lymphomas in the MHC-defined miniature swine model
... three cell lines examined in this study is lambda light chain surface ...this cell line from the other ...human B-cell lymphomas, although the etiology of this phenomenon remains undefined ...
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B cell selection and the development of autoantibodies
... that B cells play an important role in human autoimmunity is that immunotherapies that deplete B cells are very eff ective treatments for many autoimmune ...autoreactive B cells, but not at the same ...
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