Bax/Bcl-2
Bax, Bcl-2, and Bax/Bcl-2 as prognostic markers in acute myeloid leukemia: are we ready for Bcl-2-directed therapy?
... (Table 2). It is evident that Bax and Bcl-2 in bone marrow correlated significantly with their corresponding blood levels, but not consistently with ...of Bax and Bcl-2 ...
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Expression of apoptosis related genes bax, bcl-2 and bcl-X in human gastric cancer: early results of an investigation
... between bax expression and the pathological staging of for cancer ...tumoural bax expression had an advanced (III-IV) stage of ...between bcl-2 oncogene expression and the clinicopathological ...
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Is Bax/Bcl-2 Ratio Considered as a Prognostic Marker with Age and Tumor Location in Colorectal Cancer?
... carcinogenesis. Bcl-2 protein family, including anti- apoptotic (e.g. Bcl-2, Bcl-xl, and Mcl-1) and pro- apoptotic ...(e.g. Bax, Bak) members play a central role in regulation of ...
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The Vaccinia Virus-Encoded Bcl-2 Homologues Do Not Act as Direct Bax Inhibitors
... to Bcl-2 proteins, both F1 and M11L have a recognizable Bcl-2-like fold (21, 35, ...structural Bcl-2 homologs (3, 17, 28, ...endogenous Bax, Bad, and Bid, but not with Bak ...
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Studying of the Expression of BAX and BCL-2 Genes in Men with Sperm DNA Fragmentation Based on DFI and Comet Assay
... Methods: After obtaining semen samples from the patients by using gradient centrifugation method, the semen samples were centrifuged using gradient method in order to obtain pure sperm. Sperm is divided into three parts ...
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The Proapoptotic Bcl-2 Protein Bax Plays an Important Role in the Pathogenesis of Reovirus Encephalitis
... the Bax ⫺/⫺ brain following infection with T3 ...and Bax ⫺/⫺ mice infected with T3A and a lack of difference in viral growth in Bax ⫺/⫺ Bak ⫺/⫺ MEFs (81) indicate that Bax is not directly ...
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N-(2-hydroxyphenyl)acetamide (NA-2) and Temozolomide synergistically induce apoptosis in human glioblastoma cell line U87
... decreasing Bax-Bcl-2 ratio. Bax in itself does not cause cell death, but its elevated expression favors an entry into the apoptotic program following a death signal by countering ...
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Bax promoter G(－248)A polymorphism in a Turkish clinical breast cancer patients: A case control study
... by Bcl-2 family proteins that control the mito- chondrial release of death factors such as cytochrome c, AIF, Smac/DIABLO and endonuclease C ...[4-7]. BAX (Bcl-2 associated × protein) ...
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Evaluation of Apoptotic Genes Expression and Its Protein after Treatment of Cryptorchid Mice
... of Bax, Bcl-2 proper, p53 and survivin mRNA and protein were determined after performing the two treatment methods: surgical return of testis into scrotum (Exp1) and transplantation of spermatogonial ...
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Swainsonine Activates Mitochondria-mediated Apoptotic Pathway in Human Lung Cancer A549 Cells and Retards the Growth of Lung Cancer Xenografts
... of Bcl-2 fam- ily, of which Bax and Bcl-2 have been identified as major ...drugs, Bax translocates to the mitochondria and inserts into the outer mitochondrial membrane, where ...
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The role of the ubiquitin proteasome system in cerebellar development and medulloblastoma
... complex; BAX: Bcl-2-associated X protein; BCL-2: B-cell lymphoma 2; bHLH: Basic-helix-loop-helix family of proteins; BMP: Bone morphogenic protein; CGNP: Cerebellar granule ...
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Sodium fluoride induces apoptosis in cultured splenic lymphocytes from mice
... by Bcl-2 family members, is the most important intracellular apoptosis signaling ...cascade. Bcl-2 family, as a group of crucial regulatory factors in apoptosis, can indirectly regulate the ...
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Anti lipoapoptotic effects of Alisma orientalis extract on non esterified fatty acid induced HepG2 cells
... extract; Bax, Bcl-2 associated X protein; Bcl-2, beta cell lymphoma 2; BSA, bovine serum albumin; COX-2, cyclooxygenase 2; DMEM, Dulbecco ’ s modified Eagle ’ s ...
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Hederagenin from the leaves of ivy (Hedera helix L ) induces apoptosis in human LoVo colon cells through the mitochondrial pathway
... Hederagenin, a derivative of oleanolic acid isolated from the leaves of ivy (Hedera helix L.), has a strong anti-tumor effect both in vitro and in vivo [10]. Its sap- onin macranthoside B has been shown to induce apop- ...
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Interaction of Memantine with Homocysteine on the Apoptosis in the Rat Hippocampus cells
... The aim of this study was to investigate the neurotoxicity of Hcy on hippocampus cells. Hcy (0.5 µmol) was directly injected in rat hippocampus and programmed cell death (apoptosis) was analyzed by Immunohistochemistry ...
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miR 1301/TRIAP1 Axis Participates in Epirubicin Mediated Anti Proliferation and Pro Apoptosis in Osteosarcoma
... of Bcl-2, Bax, cleaved-caspase-3, and cleaved-poly (ADP-ribose) polymerase-1 (cleaved-PARP1) in U2OS and SAOS-2 cells were measured using Western ...*p<0.05. Bcl-2, B-cell ...
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Cryptotanshinone induces cell cycle arrest and apoptosis through the JAK2/STAT3 and PI3K/Akt/NFkB pathways in cholangiocarcinoma cells
... The cells were treated with CTS (0, 10, 20, and 40 μ mol/L) for 48 h. Then, the cells were harvested and lysed in a RIPA buffer (Beyotime Institute of Biotechnology, Shanghai, People’s Republic of China) and protease ...
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Differential mRNA expression of the main apoptotic proteins in normal and malignant cells and its relation to in vitro resistance
... the Bcl-2 to BAX ratio [26], and high expression of Bcl-2 protein might block p53-dependent apoptosis ...of Bcl-2 with respect to hematologic malignancies is indirectly ...
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A C-terminus Mitochondrial-localization Region and BH3 Domain of Puma are Required for Apoptotic Function
... The Bcl-2 family of proteins consist of pro-apoptotic and anti-apoptotic members that interact physically and functionally to regulate apoptosis in a cell type and stimulus specific ...the ...
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Effect of interaction of magnetic nanoparticles of Fe<sub>3</sub>O<sub>4</sub> and artesunate on apoptosis of K562 cells
... and the blots were stained with specific primary antibodies, including anti-bcl-2, anti-bax, anti-survivin, anti-bcl-rambo, anti-active caspase-3, and anti-GAPDH antibodies overnight at 4 ° C. ...
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