Bcl-2 family
In Silico Molecular Docking Analysis Of Orientin, A Potent Glycoside of Luteolin against BCL 2 Family Proteins
... Apoptosis is an implicit cell suicide pathway which plays a pivotal role in both normal and pathophysiological conditions. The intrinsic apoptotic pathway is tightly regulated by BCL-2 family ...
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Bcl-2 family proteins in breast development and cancer: could Mcl-1 targeting overcome therapeutic resistance?
... other Bcl-2 family members, Mcl-1 has a short half-life and is highly regulated at the transcriptional, post-transcriptional, translational and post-translational levels [55, 56] by various oncogenic ...
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Coaggregation of FcεRI with FcγRIIB Inhibits Degranulation but Not Induction of Bcl-2 Family Members A1 and Bim in Mast Cells
... Figures 2, 3, and ...antiapoptotic Bcl-2 family member) was up-reg- ulated both when mast cells were activated through FcRI aggregation and when they were activated through coaggregation of Fc ...
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Ardipusilloside I induces apoptosis by regulating Bcl 2 family proteins in human mucoepidermoid carcinoma Mc3 cells
... The Bcl-2 family of proteins plays an important role in regulating the mitochondrial or intrinsic apoptotic pathway ...inhibitory Bcl-2 protein is on the cytoplasmic face of the ...
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Connecting mitochondrial dynamics and life-or-death events via Bcl-2 family proteins
... the Bcl-2 family is their control of mitochondrial outer membrane permeability to release selected apoptosis-inducing factors into the cytosol during ...many BCL- 2-related proteins in ...
51
Human Cytomegalovirus Promotes Survival of Infected Monocytes via a Distinct Temporal Regulation of Cellular Bcl-2 Family Proteins
... the Bcl-2 family of mitochondrial membrane perme- ability regulators and defined a dual role for Mcl-1 in myeloid cells: regulating both cell survival and differentiation (77, ...
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Emodin inhibits colon cancer by altering BCL-2 family proteins and cell survival pathways
... Emodin, a naturally occurring anthraquinone, has a wide range of pharmacological properties that make it an attractive candidate for cancer therapeutics such as its ability to induce apoptosis, cell cycle arrest, and ...
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Cytomegalovirus Proteins vMIA and m38.5 Link Mitochondrial Morphogenesis to Bcl-2 Family Proteins
... Cellular effects of m38.5. We investigated the respective abilities of vMIA and m38.5 to interact with Bak, another proapoptotic Bcl-2 family protein that is similar to Bax and redundant with Bax, ...
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Boolean network-based model of the Bcl-2 family mediated MOMP regulation
... the Bcl-2 family interaction network using the Boolean network- based computational ...model. Bcl-2 family members have been represented by nodes, with binary encoded ...the ...
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Investigation of the pattern of expression, regulation and function of the Bcl-2 family of proteins during neuronal development and apoptosis
... of Bcl-xL did not retain its ability to interact and protect from Ced-4 ...contrast Bcl-xL, could directly bind caspases 1 and 8 in vivo, b u t failed to do so in vitro, arguing for the presence of a m a m ...
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Bcl 2 family proteins participate in mitochondrial quality control by regulating parkin/PINK1 dependent mitophagy
... of Bcl-2 family members in this process may be especially important under stress conditions where mitochondrial dam- age is ...the Bcl-2 family with respect to the regula- tion ...
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Melatonin modulates the expression of Bcl 2 family proteins in liver after thermal injury in rats
... genes Bcl-2 and ...genes Bcl-2 and Bax using light immunоchistochem- istry were investigated, ...anti-apoptotic Bcl-2 protein in sinusoidal endothelial cells (SECs) of ...
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The ZIKA Virus Delays Cell Death through the Anti-Apoptotic Bcl-2 Family Proteins
... within 2 hours after infection, we could observe a significant decrease in cell ...apoptotic Bcl-2 family proteins, abrogates the protective effects provided by ...
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Pharmacological manipulation of Bcl 2 family members to control cell death
... the Bcl-2 family of ...this family appears both feasible and efficacious, whether the goal is decreased cell death, as in ischemia of the myocardium or brain, or increased cell death, as in ...
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Sequence and partial functional analysis of canine Bcl 2 family proteins
... canine Bcl- 2 family members, at both the nucleotide and protein ...apoptosis. Bcl-2 family proteins have been assigned a central importance in the pathogenesis of various human ...
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miR-216a-5p inhibits malignant progression in small cell lung cancer: involvement of the Bcl-2 family proteins
... gene Bcl-2 is targeted by miR-216a-5p, and we identified a functional miR- 216a-5p binding site in the 3′-UTR of Bcl-2 using luciferase reporter ...of Bcl-2, Bax, and Bad ...
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Constitutive expression of the anti apoptotic Bcl 2 family member A1 in murine endothelial cells leads to transplant tolerance
... the Bcl-2 family have been shown to have dual functionality in as much as they inhibit cell death but also regulate ...a Bcl-2 family member, under the control of the human ...
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Emerging role for members of the Bcl 2 family in mitochondrial morphogenesis
... the Bcl-2 family contribute to the regulation of mitochondrial dynamics, how does this operate at a molecular level? This is where confusion currently reigns, because interac- tions have been ...
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Therapeutic Modulation of Apoptosis: Targeting the BCL 2 Family at the Interface of the Mitochondrial Membrane
... In conclusion, the repertoire of potential structures in our arsenal must include more than the hydrophobic alpha helices that have been the focus of so much study and development. The contribution of electrostatics, and ...
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New dimension in therapeutic targeting of BCL-2 family proteins
... the BCL-2 family control the mitochondrial pathway of ...the family are specific antagonists of prosurvival ...targeting BCL-2 family proteins highlight several new ...
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