BCS Class-II Drugs
Amorphous solid dispersions of BCS class II drugs: a rational approach to solvent and polymer selection
... of BCS class II ...Four drugs, seven polymers and five solvents have been ...the drugs, the functionality of the polymeric excipients and the physical properties of the ...
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EVALUATION OF A NEW COPROCESSED EXCIPIENT AS CARRIER FOR ENHANCING THE DISSOLUTION RATE OF POORLY SOLUBLE BCS CLASS II DRUGS
... The objective of the present study is to prepare and characterize a new co-processed excipient namely pre-gelatinized starch - PEG 1500 – Aerosil (PGS-PEG-Aerosil) and to evaluate its application as a carrier in solvent ...
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Formulation and development of some BCS Class II drugs
... 2 Dept. of Pharmaceutical Science, JJT University Rajasthan 3 Department of Pharmaceutics, VT’ Shivajirao S. Jondhle College of Pharmacy, Thane, Maharashtra, India ABSTRACT The aim of this research was to develop and ...
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IMPROVING SOLUBILITY OF BCS CLASS II DRUGS USING SOLID DISPERSION: A REVIEW
... certain drugs for which solubility has presented a challenge for developing suitable formulation for oral administration 2 ...such drugs can be improved by incorporating the drug in a hydrophilic carrier ...
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GREEN SYNTHESIS OF NANOSILVER AND ITS EFFECT ON PHASE SOLUBILITY OF FEW BCS CLASS II DRUGS
... all drugs was observed in presence of 30% V/V of NS ...of drugs and promote ionic or interactive binding with NS, further investigation is needed to confirm the type of interaction between NS and ...
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Assessment of nanocomposites vs. amorphous solid dispersions for dissolution enhancement of bcs class ii drugs
... five drugs wet-milled in the stirred media ...various drugs would be expected to be different due to their different mechanical and physico-chemical properties, Figure ...all drugs as the coarser ...
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LIQUISOLID SYSTEMS - AN EMERGING STRATEGY FOR SOLUBILIZATION & DISSOLUTION RATE ENHANCEMENT OF BCS CLASS-II DRUGS
... lipophilic drugs/water insoluble drugs in order to increase their clinical ...lipophilic drugs, or water-insoluble solid drugs dissolved in suitable nonvolatile solvents have been converted ...
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Influence of physiological gastrointestinal surfactant ratio on the equilibrium solubility of BCS class II drugs investigated using a four component mixture design
... water-soluble drugs is in fl uenced by the luminal gastrointestinal fl uid content and composition, which control ...soluble drugs through more complex biorelevant amphiphile ...spironolactone) drugs ...
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Advanced PEGylation for the Development of Raloxifene Hydrochloride, BCS Class II Drug
... Raloxifene hydrochloride (RLX) is a beta-selective beta- andregenic blocking agent, which is indicated to prevent osteoporosis in post-menopausal women. Chemically, it is [6 – hydroxy–2 (4-hydroxy phenyl)-benzothiophen- ...
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ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF BCS CLASS II DRUG RITONAVIR USING LIQUISOLID TECHNIQUE
... ABSTRACT: BCS class II drugs usually suffer inadequate bioavailability as a dissolution step is the absorption rate-limiting ...these drugs was investigated using ritonavir as a drug ...
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Roles of surfactant and binary polymers on dissolution enhancement of bcs ii drugs from nanocomposites and amorphous solid dispersions
... 63 The combination of 2.5% HPC SL and 0.2% SDS led to the finest ITZ particles and a 7-day stable suspension. HPC–SDS provides synergistic stabilization during milling and storage for a multitude of BCS ...
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Formulation and Development OF BCS Class II Drug
... 2 Dept. of Pharmaceutical Science JJT University Rajasthan, India 3 VT’ Shivajirao S. Jondhle College of Pharmacy, Thane, Maharashtra, India ABSTRACT The aim of this research was to develop and evaluate liquisolid ...
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Application of factorial design for enhancement of dissolution of bcs class iv drugs
... 8021 CONCLUSIONS In this TBZ tablet formulation was optimized using 2 4 partial factorial designs. Mathematical model can be utilized to produce accurate representation of the relationship between the independent ...
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MICROENCAPSULATION BY SOLVENT EVAPORATION METHOD OF BCS CLASS 4 DRUGS FOR BIOAVAILABILITY ENHANCEMENT
... Pyrolidones-based microcapsules of PVPK-30 1, 2, 3 , soluplus 4,5 have been used as biodegradable layer for fast release drugs. Solvent evaporation techniques have become more useful method as compared to other ...
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LIQUISOLID TECHNIQUE: A NOVEL APPROACH TO ENHANCE SOLUBILITY AND BIOAVAILABILITY OF BCS-II DRUGS
... However, due to the presence of the residual solvent in the drug formulation, it is disadvantageous to use toxic solvents 18-19 . To overcome the problem, the technique of ‘liquisolid compacts’ is a new and promising ...
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EFFECT OF PHYSICAL MODIFICATION ON DISSOLUTION OF NABUMETONE: A BCS CLASS II DRUG
... of BCS class II drug Nabumetone (NBT) was studied for dissolution in water and pharmacopoeial dissolution media (2%w/v sodium lauryl sulfate in ...
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Preparation and in vitro Evaluation of Fast Disintegrating Tablets of BCS Class II Drug
... Pranlukast is a BCS class II drug having absolute bioavailability of approximately 4.3%. To improve the biological performance of Pranlukast solid dispersion with oral disintegrating tablets were ...
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Solubility Enhancement of BCS Class II Drug By Solid Dispersion Technique – Fabrication and Evaluation.
... Decreasing local tissue irritation. Masking unpleasant taste. Future Prospects Despite many advantages of solid dispersion, issues related to preparation, reproducibility, formulation, scale up and stability limited its ...
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Preparation of Polymer Nanocomposites for Enhancement of Solubility and Dissolution Rate of BCS Class II Drug
... 1 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422 213, Maharashtra, India. 2 Department of Pharmaceutical Chemsitry, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422 213, ...
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EMERGING LIQUISOLID COMPACT TECHNOLOGY FOR SOLUBILITY ENHANCEMENT OF DRUG ROSUVASTATIN BCS CLASS-II
... The objective of the study was to increase the solubility, and dissolution rate of Rosuvastatin Calcium. The in vitro dissolution property of slightly water soluble rosuvastatin calcium was improved by exploring the ...
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