BENZIMIDAZOLE DERIVATIVE

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SYNTHESIS AND CHARACTERISATION OF 2 (4 THIAZOLYL) BENZIMIDAZOLE DERIVATIVE

SYNTHESIS AND CHARACTERISATION OF 2 (4 THIAZOLYL) BENZIMIDAZOLE DERIVATIVE

Benzimidazole is heterocyclic compound. we synthesized the derivative of 2-(4-Thiazolyl) Benzimidazole derivative. The synthesis of novel Benzimidazole derivatives and investigation of their chemical and biological behavior have gained more importance in recent decades. During the recent years there has been intense investigation of different classes of Benzimidazole nucleus are known to exhibit unique anti bacterial, anti oxidant, anti fungal, anti histaminic, anti psychotic ,narcotic analgesic, proton pump inhibitor-anti ulcer, anti dopamenergic, anti coagulant activities respectively. The structure of synthesized compound was confirmed by 1 H-NMR and Mass spectroscopy.
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Anti-Ulcerogenic Effect of 2-(Pyrimidinylsulfinyl) Benzimidazole Derivative Against Different Ulcerogenic Agents In Rats

Anti-Ulcerogenic Effect of 2-(Pyrimidinylsulfinyl) Benzimidazole Derivative Against Different Ulcerogenic Agents In Rats

Gastric ulcerations were induced experimentally in male Wistar rats according to the Asano method [12].Following a 24 h fasting with water ad libitum, rats were dosed orally with different doses of 2-(pyrimidinylsulfinyl) benzimidazole derivative (BD), cimetidine and vehicle (Tween 80). One hour later 300mg/kg per oral of ASA was administered. The animals were sacrificed 4 h after ASA dosing; stomach was removed and observed for percent protection of ulcerative lesions.

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Electrochemical, Thermodynamic and Quantum Chemical Studies of Synthesized Benzimidazole Derivative as an Eco- Friendly Corrosion Inhibitor for XC52 Steel in Hydrochloric Acid

Electrochemical, Thermodynamic and Quantum Chemical Studies of Synthesized Benzimidazole Derivative as an Eco- Friendly Corrosion Inhibitor for XC52 Steel in Hydrochloric Acid

According to Lukovits [92], the chemisorption and inhibition effectiveness increases with the elevating in the electron transfer ability to the metal surface. This shows that as the strength of the iron-inhibitor bond increases (as a result of the increase of ∆N), the degree of corrosion inhibition due to chemisorptions is increased. As previously cited in the literature, the chemisorption of inhibitor molecules provides higher corrosion inhibition when compared to physic-sorption process. According to the experimental data, the corrosion inhibition efficiency of MMBI is high. This is manifested by the high number of electrons transferred (∆N) which has been found to be equal to 0.83 confirming the good inhibition efficiency and good chemical adsorption of this benzimidazole derivative. From Table 5, the low electrophilicity ω = 2.05 and the high fraction of electrons transferred value N=0.83 agree with the good and high inhibition efficiency of the studied inhibitor. Table 5 shows that N is positive and less than 3.6 [93, 94], confirming that the inhibitor can donate electrons to iron to form coordinate bonds and results consequently an adsorption inhibitive layers against corrosion.
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Amelioration of 1, 2 Dimethylhydrazine Induced Tumor Promotion Response by Novel Benzimidazole Derivative Nanoparticle in Wistar Rats

Amelioration of 1, 2 Dimethylhydrazine Induced Tumor Promotion Response by Novel Benzimidazole Derivative Nanoparticle in Wistar Rats

imidazol-2-yl)-6-phenylpyrimidin-2-amine loaded chitosan nanopar- ticles formulated and characterized, these results demonstrate that the possibility of delivering synthesised novel benzimidazole derivative 4-(1H-benzo[d]imidazol-2-yl)-6-phenylpyrimidin-2-amine loaded nano - particle (BZI 3 nano) to colorectum with enhanced encapsulation effi- ciency. Additionally the nanoparticle (BZI 3 nano) have been evaluated for In vitro cytotoxicity in Caco2 and MCF- 7 cell lines. In vitro cytotoxicity study suggested the safety of the prepared novel nanoparticle (BZI 3 nano), which can be potential carrier to deliver hydrophilic drugs to target colorectum. 9 Further In vivo will confirm the targeting efficiency of
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Synthesis and Biological Evaluation of Some Novel Benzimidazole Derivative with Aspirin As Potent Antimicrobial & Antifungal Agents L.

Synthesis and Biological Evaluation of Some Novel Benzimidazole Derivative with Aspirin As Potent Antimicrobial & Antifungal Agents L.

In the present work, the novel Benzimidazole derivative was synthesized with Aspirin and evaluated for their antimicrobial & antifungal activities. The newly synthesized compound was subjected to antibacterial activity against Staphylococcus aureus ATCC 250, Pseudomonas aeruginosa ATCC 25619, Escherichia coli RSKK 313 & antifungal activity against Candida albicans RSKK 628. The antibacterial & antifungal activities were compared with the respective standard drugs. The MIC of Benzimidazole derivative was found to be in the range 20-200 mg/ml on all the tested microorganisms. KEYWORDS: Benzimidazole, Synthesis, Aspirin, Antimicrobial, Antifungal.
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Synthesis and spectroscopic studies of mixed ligand complexes of transition and
inner transition metals with a substituted benzimidazole derivative and RNA bases

Synthesis and spectroscopic studies of mixed ligand complexes of transition and inner transition metals with a substituted benzimidazole derivative and RNA bases

Few mixed ligand complexes of Transition and Inner transition metals have been synthesized by reacting their metal salts with a substituted benzimidazole derivative, Omeprazole and RNA bases, uracil /adenine. All the complexes were synthesized in ethanolic medium and refluxed in reaction medium. The yield percentage ranging from 80-90%. The complexes are coloured solids and of the type [M(Ome)(Ade) 2 .2H 2 O)]SO 4 .xH 2 O.and

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Electrochemical Synthesis of Benzimidazole Derivative Using Carbon Electrode in Aqueous Medium

Electrochemical Synthesis of Benzimidazole Derivative Using Carbon Electrode in Aqueous Medium

quinone is then attacked by carbohydrazide to form benzimidazole derivative adduct. From the point of view of green chemistry, the use of electrosynthesis method has some significant benefits. The use of electricity as an energy instead of oxidative reagents, clean synthesis, one-step reaction, use of aqueous media instead of organic solvents, technical applicability, work in room temperature and pressure, and especially significantly high atom economy are of preeminent green advantages.

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SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME BENZIMIDAZOLE DERIVATIVE WITH IBUPROFEN

SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME BENZIMIDAZOLE DERIVATIVE WITH IBUPROFEN

important heterocyclic ring, because of its synthetic utility and broad range of pharmacological activities. Some benzimidazole derivatives with different pharmacological effects, including antifungal 1 , anti-helmintic 2 , anti-HIV 3 , antihistaminic 4-6 , antiulcer 7, 8 , cardio tonic 9 , antihypertensive 10, 11 and neuroleptic 12 , are in clinical use. In order to obtain more effective chemotherapeutic agents, a variety of reports have been presented on the synthesis and biological evaluation of new benzimidazole derivatives 13 . Many reports have revealed that the influence of the substitution at the 1, 2 and 5 positions of the benzimidazole ring is very important for their pharmacological effects 14, 15 . 2-(substituted phenyl)-benzimidazoles with various types of biological activities, such as antibacterial 16, antiviral 17 , antitumoral 18, 19 and anti-inflammatory
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In vivo Evaluation of Antiproliferative Activity of a Novel Benzimidazole Derivative Against Daltons Lymphoma  Ascitic in Swiss Albino Mice

In vivo Evaluation of Antiproliferative Activity of a Novel Benzimidazole Derivative Against Daltons Lymphoma Ascitic in Swiss Albino Mice

level of total cholesterol, triglycerides, AST, ALT and ALP in serum indicates liver damage. Based on the above reports various Benzimidazole deriv- atives were designed and screened for the physico- chemical parameters with the aid of bio- informatics tools like ACD Lab Chemsketch, Mo- linspiration, PASS, Schrodinger Glide XP etc. With the help of these parameters, compound (N-[3- chloro-2-oxo-4-(2-hydroxyphenyl)-4-oxoazetidin- 1yl]-2-(2-methyl-1H-benzimidazole-1-

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Identification of a New Benzimidazole Derivative as an Antiviral against Hepatitis C Virus

Identification of a New Benzimidazole Derivative as an Antiviral against Hepatitis C Virus

To analyze the effect of B5 on HCV genome replication, Huh-7 cells were electroporated with in vitro-transcribed JFH1 RNA to bypass the entry step and avoid any interference with late st[r]

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Synthesis and Pharmacological Evaluation of Some Novel Imidazole Derivatives for Their Potential Anti-hypertensive Activity

Synthesis and Pharmacological Evaluation of Some Novel Imidazole Derivatives for Their Potential Anti-hypertensive Activity

Concentrated nitric acid (7.5 mL) was placed in 3-necked RBF fitted with a mechanical stirrer. The flask was immersed in ice cold water and concentrated sulphuric acid (7.5 mL) was added slowly down the condensor with slow stirring. Afterwards, 2-substituted benzimidazole derivative (IIIa-IIIe) was added in portion over a period of 1h at such a rate that the temperature did not exceed 35 0 C. After continuous stirring for 10-13 h, the reaction mixture was

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SYNTHESIS AND BIOLOGICAL SCREENING OF BENZIMIDAZOLE DERIVATIVES

SYNTHESIS AND BIOLOGICAL SCREENING OF BENZIMIDAZOLE DERIVATIVES

Synthesis of benzimidazole derivative: The equimolar amount of amines derivatives and o-phenylenediamine were diluted in equimolar amount of dimethyl formamide (DMF) as solvent to a different round bottom flask and both are mixed and stirred for 30 min. and this solution was keeping for overnight and then in this solution we added iodine as catalyst in

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Synthesis and Characterization of Some New Nucleoside Analogues from Substituted Benzimidazole via 1,3-Dipolar cycloaddition

Thanaa M. Al-Mouamin | Ahmed Kh. Kadhim

Synthesis and Characterization of Some New Nucleoside Analogues from Substituted Benzimidazole via 1,3-Dipolar cycloaddition Thanaa M. Al-Mouamin | Ahmed Kh. Kadhim

General procedure for the preparation of 1-propynyl – 2- substituted phenyl benzimidazole Prepared benzimidazole derivative(10 mmol) was heated under refluxe with alcoholic potassium hydroxide (4 M) for 0.5 hrs. then (0.88ml, 10 mmol) of propargyl bromide was added and was heated under reflux in boiling water bath for 3-4 hrs. , filtered and recrystallized from ethyl acetate.

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Synthesis, Characterization and Biological Evaluation of Some Novel NMannich Bases of Benzimidazole Derivatives.

Synthesis, Characterization and Biological Evaluation of Some Novel NMannich Bases of Benzimidazole Derivatives.

13.5 g (0.125 mol) of O-phenylene diamine was placed in a 250 ml of round bottom flask and added 10.2 g (0.17 mol) of acetic acid. The mixture was heated on a water bath at 100° C for 6-8 h, cooled and added 10% sodium hydroxide solution slowly with constant rotation of the flask, until the mixture was just alkaline to litmus. The crude benzimidazole derivative was filtered at the pump, and then washed with ice cold water, drained well and washed again with 25 ml of cold water. The crude product was dissolved in 200 ml of boiling water; 2 g of decolorizing carbon was added and digested for 15 min. The product was filtered rapidly at the pump through preheated buchner funnel and flask. The filtrate was cooled to about 10° C and the filtered product of 2-methyl-benzimidazole was again washed with 25 ml of cold water, dried at 100° C and weighed. (Vogel’s 2006, Ahuluwalia V.K. et al., 2000, Ansari K.F. et al., 2009)
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Quantification of Valsartan by Uv-Visible and NMR Spectroscopy.

Quantification of Valsartan by Uv-Visible and NMR Spectroscopy.

The present work entitled “Quantification of Valsartan by UV-Visible and NMR spectroscopy comprises of UV-Visible spectrophotometric method and QNMR methods for estimation of Valsartan. The Ultraviolet method involves the determination of Valsartan by different methods like standard absorbance method, area under curve, derivative spectroscopy and Q-absorbance method. The drug obeyed Beer’s law at the concentration of 5-30µg/mL. The correlation coefficient was found to be 0.99 for all the method. The low percentage RSD value shows that the methods developed are not affected by the presence of sample matrix (or) devoid of interference by the excipients. The visible method involve Acid dye complexation with Bromo thymol blue and Bromo phenol blue. Both the methods obeyed Beer’s law at the concentration of 100-600µg/mL for Bromo thymol blue and 40-240µ g/mL for Bromo phenol blue. The correlation coefficients were within the limit, and RSD percentage was low. Thus the methods were precise, specific and accurate.
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Comparative Study of RP-HPLC and UV Spectrophotometric Techniques for the Simultaneous Determination of Amoxicillin and Cloxacillin in Capsules

Comparative Study of RP-HPLC and UV Spectrophotometric Techniques for the Simultaneous Determination of Amoxicillin and Cloxacillin in Capsules

Reversed-phase HPLC and UV spectrophotometric techniques using water as solvent have been developed and validated for the simultaneous determination of amoxicillin and cloxacillin in capsules. For both techniques, the linearity range of 60.0–140.0 µ g/mL was studied. The spectrophotometric data show that non-derivative techniques, such as absorbance ratio and compensation, and ratio spectra first-order derivative could be successfully used for the co-assay of amoxicillin and cloxacillin. Based on the statistical comparison of spectrophotometric and chromatographic data, the interchangeability between HPLC and UV spectrophotometric techniques has been suggested for the routine analysis.
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1,2 Di­phenyl 1H benzimidazole

1,2 Di­phenyl 1H benzimidazole

Fused imidazole derivatives such as benzoimidazoles and phenanthroimidazoles [Fang et al., (2007), Ge et al., (2008), Lai et al., (2008)] have been used in the fabrication of light-emitting devices, employing them as electron-transporting layer and as sensitizers in dye-sensitized solar cells [Shin et al., (2007), Tsai et al., (2007)] due to their wide optical absorption, bright luminescence and bipolar transport characteristics. Since our research group is working in organic light emitting devices, we are interested to use the title compound as ligand for synthesizing Ir(III) complexes. Jayamoorthy et al., (2012) have reported a closely related crystal structure of 2-(4-Fluorophenyl)-1-phenyl-1H-benzimidazole.
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Estimating current derivatives for sensorless motor drive applications

Estimating current derivatives for sensorless motor drive applications

This paper has presented a new method capable of estimating current derivatives using phase current measurements affected by high frequency oscillations obtained using a standard industrial current sensor. The effectiveness of the technique has been demonstrated in a real-time experimental environment. Under long PWM pulse widths the ANN derivative estimates are comparable to those obtained from a Rogowski coil and 2IS methods. The estimated derivatives can be used to successfully identify the saturation saliency component in the face of variations in shaft speed and loading.

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2 (Methyl­sulfan­yl) 1H benzimidazole

2 (Methyl­sulfan­yl) 1H benzimidazole

distances in the range 0.93–0.97 A Data collection: SMART Bruker, 2001; cell refinement: SAINT Bruker, 2001; data reduction: SAINT; programs used to solve structure: SHELXS97 Sheldrick, [r]

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Polymorph β of 1H benzimidazole

Polymorph β of 1H benzimidazole

1H-Benzimidazole, (I), is a simple heterocyclic aromatic compound used in organic synthesis. It is known as a white substance, slightly soluble in water, with a melting point of 445 K and a crystal density of 1.23 Mg m 3 . To the best of our knowledge, the only information that (I) can be dimorphic comes from the work of Doman´ska & Bogel-Łukasik (2003), who observed a solid–solid first-order phase transition of (I) in differential scanning calorimetry measurements during their solubility studies of benzimidazoles in alcohols.

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