BET protein
Intra- and Intercellular Trafficking of the Foamy Virus Auxiliary Bet Protein
... The Bet protein of foamy viruses (FVs) is an auxiliary protein encoded by the 3 ⴕ end of the viral ...unknown, Bet seems to play a key role in the establishment and/or maintenance of viral ...
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BET protein inhibitor JQ1 inhibits growth and modulates WNT signaling in mesenchymal stem cells
... [1–3]. BET proteins contain two related bromodomain (BD) motifs, BD1 and BD2, located at the amino acid terminal region, and one extra-terminal (ET) domain located either at the carboxyl terminal region of the ...
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BET protein inhibition regulates cytokine production and promotes neuroprotection after spinal cord injury
... of BET proteins by JQ1 treatment during an inflammatory response [22, ...after BET inhibition are elusive. This effect may be indirect. However, BET protein BRD4 can confer transcriptional ...
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Original Article BET protein BRD4 as a new therapeutic target in cerebral ischemic stroke
... C-reactive protein (CRP), interleukin-6 (IL-6) and serum amyloid A (SAA), are associated with an unfa- vorable outcome and increased mortality after stroke [5, ...
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<p>Combination BET Family Protein and HDAC Inhibition Synergistically Elicits Chondrosarcoma Cell Apoptosis Through RAD51-Related DNA Damage Repair</p>
... (BET) protein 6 , [Zhang et al, ...targeting BET proteins, including JQ1, have been undergoing clinical trials and have exhibited excel- lent ef fi cacy in suppressing cell growth in a wide range of ...
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BET bromodomain protein inhibition is a therapeutic option for medulloblastoma
... The BET protein family contain tandem bromodomains and an extraterminal or ET domain ...Human BET family members include BRD2, BRD3, BRD4 and BRDT ...a protein containing the first three ...
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Individual T helper cells have a quantitative cytokine memory
... T- bet protein and IFN-γ production in fully committed, already IFN-γ–competent Th1 cells, we sorted Th1 cells for different amounts of IFN-γ secretion (and thus indirectly also for different T-bet ...
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An Evolutionarily Conserved Splice Generates a Secreted Env-Bet Fusion Protein during Human Foamy Virus Infection
... the Bet protein, a mouse monoclonal Ab (B4) against the SU domain of the Env protein, and rabbit polyclonal anti-Bel1 and anti-Bel2 antisera (kindly provided by ...to Bet, gp160, and gp130 ...
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The bromodomain inhibitor N-methyl pyrrolidone reduced fat accumulation in an ovariectomized rat model
... are protein mo- tifs binding acetyl-lysine residues of nucleosomal his- tones or other proteins ...[17]. BET-proteins contain two bromodomain domains and an extraterminal domain ...form protein ...
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Foamy Virus Bet Proteins Function as Novel Inhibitors of the APOBEC3 Family of Innate Antiretroviral Defense Factors
... PFV Bet protein, a cytoplasmic auxiliary protein of previously uncertain function, Bet failed to relieve inhibition caused by murine ...PFV Bet bound to human, but not mouse, APOBEC3 ...
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The Interaction of the Gammaherpesvirus 68 orf73 Protein with Cellular BET Proteins Affects the Activation of Cell Cycle Promoters
... of BET proteins is the highly conserved extra terminal (ET) domain (see ...a protein-protein interaction module in Brd2, Brd3, and Brd4 with KSHV LANA-1 (45, 47, 65) and between the yeast ...
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Arsenic sulfide amplifies JQ1 toxicity via mitochondrial pathway in gastric and colon cancer cells
... the BET protein BRD4 and the resulting inhibition of c-Myc, co-treatment with AS and JQ1 attenuated the expression of several prosurvival genes, including NFATs and Bcl-2, in GC and colon cancer ...
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Pharmacological targeting of BET proteins inhibits renal fibroblast activation and alleviates renal fibrosis
... of BET inhibitors has also been tested in animal models of tissue ...fibrosis, BET inhibitors were shown to prevent liver injury and reverse the progression of existing fibrosis ...of BET ...
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Characterization of a Human Foamy Virus 170-Kilodalton Env-Bet Fusion Protein Generated by Alternative Splicing
... Env protein and its cleavage ...HFV protein expression was examined by RIPA with different antisera in cell lysates ...cellular protein expression showed that the 170-kDa protein is ...
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Online gambling and crime: a sure bet?
... be bet once all other funds have been ...first bet to wager both his original stake and any winnings on a second bet before he can bet with his ...must bet through before he can ...
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Pre Decision Side Bet Sequences
... side bet from a degenerate menu restricted to the least-disadvantageous class of betting offered by the gaming industry: single-number wagers on a European roulette ...
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Pre Decision Side Bet Sequences
... side bet, accepting the indivisible risky prospect conditional upon winning the side ...such bet will be ...side bet wealth may still remain within the interval of interim (utility) convexity, ...
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Double bromodomain protein BET 1 and MYST HATs establish and maintain stable cell fates in C elegans
... in bet-1 mutants carrying osm-6::gfp, which is expressed earlier than ...11 bet-1 mutants, suggesting that cell fates might not be correctly specified in these animals (see ...of bet-1 mutants (93%, ...
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Targeting BET bromodomain proteins in solid tumors
... that BET inhibitors are effective against chemotherapy-resistant PDAC cells, in part through repression of HMGA2 [16], a non-histone DNA- binding nuclear protein involved in chromatin remodeling and gene ...
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Antimicrobial peptides and their potential application in inflammation and sepsis
... Th erefore, from these and earlier data, the change of lipid A/LPS cubic aggregate into a multilamellar structure is an important step in the ability of the peptides to neutralize endotoxins, associated with an extremely ...
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