beta-2 adrenergic receptor
A single-nucleotide polymorphism of the beta 2-adrenergic receptor gene can predict pathological complete response to taxane- and platinum-based neoadjuvant chemotherapy in breast cancer
... the beta 2-adrenergic receptor (ADRB2) gene in predicting pathological complete responses (pCRs) to taxane- and platinum-based neoadjuvant chemotherapy in locally advanced breast cancer ...
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EFFECT OF GLY 16 ARG SINGLE NUCLEOTIDE POLYMORPHISM ON AGONIST BINDING TO BETA 2 ADRENERGIC RECEPTOR – A STRUCTURAL PHARMACOGENOMIC APPROACH
... human beta 2-adrenergic receptor: a protein with multiple membrane- spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for ...
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Molecular characterization of [beta]2 adrenergic receptor haplotypes
... Chronic pain is any pain that persists in the absence of normal pain-evoking stimuli. The pain can be intermittent or constant, and often does not have a clear cause. One of the main symptoms is hyperalgesia, heightened ...
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Evaluation of spirometry values in relation to beta-2-adrenergic receptor gene polymorphism
... claimed that this genotype has the lowest frequency within g. 46 [21]. Frequencies of genotype g. 46gg re- ported by taylor et al [39], Lima et al [26], Hopes et al [14], Martinez et al [29], and Azis et al [5] are ...
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Genetic polymorphisms of the beta 2 adrenergic receptor in nocturnal and nonnocturnal asthma Evidence that Gly16 correlates with the nocturnal phenotype
... of beta 2AR as compared to arginine at this position ...the beta 2AR genotypes of two well-defined asthmatic cohorts: 23 nocturnal asthmatics with 34 +/- 2% nocturnal depression of peak expiratory ...
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Expression of the beta-2 adrenergic receptor (ADRB-2) in human and monkey ovarian follicles: a marker of growing follicles?
... Methods: We studied expression of ADRB-2 in human and rhesus monkey ovary (RT-PCR, immunohistochemistry; laser micro dissection) and measured levels of norepinephrine (NE; ELISA) in monkey follicular fluid (FF). ...
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[beta]2-adrenergic receptor modulation of macrophage inflammatory mediator production
... transcriptional regulation of several pro-inflammatory molecules, the mechanisms surrounding TNF-α production are the most studied. In 2000, Farmer and Pugin published a landmark paper describing the molecular basis of ...
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Beta-adrenergic receptor stimulation limits the cellular proarrhythmic effects of chloroquine and azithromycin
... Six-months after its first identification in Wuhan, China in December 2019, Severe Acute Respiratory Syndrome-associated Coronavirus type-2 (SARS-CoV-2) infection (i.e., Coronavirus Disease 2019 / COVID-19) ...
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A paired sibling analysis of the beta 3 adrenergic receptor and obesity in Mexican Americans
... chromosome 2 which we have shown previously to be tightly linked to obe- sity in this ...words: beta-3- adrenoreceptor • obesity • polymorphism • insulin ...
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Science review: Mechanisms of beta receptor stimulation induced improvement of acute lung injury and pulmonary edema
... Beta-2 adrenergic agonists modulate the expression of the epithelial apical sodium channel as well as the expression of the Na,K-ATPase ...the beta blocker propranolol were added, the rate of ...
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Protective effects of a glucocorticoid on downregulation of pulmonary beta 2 adrenergic receptors in vivo
... increased beta 1- and beta 2-receptor numbers by 70 and 69% above control, respectively, but did not change their mRNA ...days 2-8) decreased beta 1- and beta ...
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Pinpointing beta adrenergic receptor in ageing pathophysiology: victim or executioner? Evidence from crime scenes
... in chronically failing cardiomyocytes [76], with significant functional sequelae [77]. A similar remodeling of cell sur- face topography may be involved in ageing, but no specific studies are currently available to ...
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CHARITY: Cha gas car diomyopathy bi soprolol int ervention study: a randomized double blind placebo force titration controlled study with Bisoprolol in patients with chronic heart failure secondary to Chagas cardiomyopathy [NCT00323973]
... to beta-blockade could be expected to be beneficial in this situation, even in non ischemic CHF ...circulating beta-adrenergic antibodies in Cha- gas' disease providing further theoretical support ...
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Hypoxia and glucose independently regulate the beta adrenergic receptor adenylate cyclase system in cardiac myocytes
... the beta-adrenergic receptor (beta AR)-adenylate cyclase system in a model of hypoxic injury in cultured neonatal rat ventricular ...After 2 h of hypoxia in the presence of 5 mM ...
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Impaired beta adrenergic receptor binding and function in cystic fibrosis neutrophils
... abnormal adrenergic and cholinergic physiologic responses in addition to decreased beta adrenergic-induced cyclic AMP generation in human ...assessing beta adrenergic receptor ...
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Effect of dietary supplementation with Spirulina on the expressions of AANAT, ADRB3, BTG2 and FASN genes in the subcutaneous adipose and Longissimus dorsi muscle tissues of purebred and crossbred Australian sheep
... (AANAT), Adrenergic beta-3 receptor (ADRB3), B-cell translocation gene 2 (BTG2) and Fatty acid synthase (FASN) genes, which are associated with lipid ...
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Genetic and epigenetic interactions in adaptive thermogenesis pathways in association with obesity from a Public Health Genomics perspective
... mellitus 2, cardiovascular and musculoskeletal systems diseases and some types of cancers as for example oesophagus, pancreas, colon, rectum, breast (after menopause), endometrium (lining of the uterus), kidney, ...
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Anti-tumor activity of the beta-adrenergic receptor antagonist propranolol in neuroblastoma
... Despite the discrepancy between in vitro and in vivo concentrations the doses effective against NB SK- N-AS xenografts were similar to those used in regimens for hypertension and those reported for children with ...
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Reduced beta adrenergic receptor activation decreases G protein expression and beta adrenergic receptor kinase activity in porcine heart
... alpha 2 and Gs alpha mRNA and protein expression in the left ventricle; reduced G-protein content was also found in the right ...in beta-adrenergic receptor-dependent stimulation of adenylyl ...
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Beta adrenergic receptor polymorphisms: A basis for pharmacogenetics
... Gln/Glu (amino acid substitution of glutamine for glu- tamic acid at position 27 resulting in the nucleotide sub- stitution of cytosine for guanine at position 79 (79 C/G), rs1042714). Single-nucleotide polymorphisms ...
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