Beta Cell Function
The association of depression and perceived stress with beta cell function between African and Haitian Americans with and without type 2 diabetes
... of beta cell dysfunction with depres- sion and perceived stress is ...with beta cell function between African and Haitians Americans with and with- out type 2 ...
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Effects of hemipancreatectomy on pancreatic alpha and beta cell function in healthy human donors
... measured by glucose potentiation of arginine-induced insulin secretion, was significantly decreased in donors (maximal acute insulin response [AIRmax]: donors = 666 +/- 84 pM vs controls = 1,772 +/- 234 pM) while the ...
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Preservation of insulin mRNA levels and insulin secretion in HIT cells by avoidance of chronic exposure to high glucose concentrations
... pancreatic beta cell is considered to play a secondary role in the pathogenesis of type II diabetes ...of beta cell function in HIT cells passed serially under high glucose conditions ...
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Therapeutic concentrations of antidepressants inhibit pancreatic beta cell function via mitochondrial complex inhibition
... plasma concentration for these ADs are well established to be related to dose (Reis et al., 2009), a daily fluoxetine dose of 80 mg can yield steady state plasma concentrations >2 µM (Lundmark et al., 2001), a ...
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Impaired pancreatic beta cell function in the fetal GK rat Impact of diabetic inheritance
... b cell mass (3), hepatic glucose overproduction, and moderate peripheral insulin resistance in muscles and adipose tissues ...b cell defects in the etiology of NIDDM in the GK ...b cell mass (7), it ...
7
Detection of amplifiable mRNA extracellular to insulin producing cells: potential for predicting beta cell mass and function
... reflects beta cell function (i.e., specifically the ability of beta cells to release insulin in a glucose-regu- lated manner), we conducted analyses of mRNAs in medium conditioned by ...
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Impaired beta cell function is present in nondiabetic rheumatoid arthritis patients
... Elevations in the ratio of proinsulin to insulin, as well as in absolute proinsulin concentrations adjusted for fasting insulin, have been postulated as early markers of b-cell dysfunction [26]. However, ...
10
The Short and Long Term Effect of Liraglutide on the Beta Cell Function in Type 2 Diabetic Patients
... β cell function, a 75-g oral glucose tolerance test was performed twice, first im- mediately before the initiation of liraglutide therapy and second immediately after increasing the dose to ...-cell ...
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Long term fenofibrate treatment impaired glucose stimulated insulin secretion and up regulated pancreatic NF kappa B and iNOS expression in monosodium glutamate induced obese rats: Is that a latent disadvantage?
... on beta cell function in a metabolic syndrome animal model, monosodium glutamate (MSG) induced obese ...of beta cell insulin ...the beta cell function in ...
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Effect of protein glycation by methylglyoxal on pancreatic beta cell function
... on beta cells and involvement in early stage dysfunction and development of type 2 diabetes mellitus are not ...on beta cell function and related involvement in the development of ...of ...
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Effect of Lifestyle Modification and Oral Anti Diabetic Drugs on Metabolic Parameters in Recently Diagnosed Patientswith Uncomplicated Type 2 Diabetes Mellitus in Eastern India
... Patients in the group 2 were observed to have significant improvement in all the parameters. A review on metformin by Goley showed that effect of met- formin on body weight in various randomized controlled trials was ...
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A New Fuzzy Control Model for Kidney Patients
... measure is less than one, a body hasn’t insulin resistance. Otherwise the body has insulin resistance. If patient’s insulin resistance is 0.999 and for other patient is 1.001, can we conclude that the first patient has ...
5
Diabetes Mellitus: the Role of the Laboratory- an Update
... the beta cells of the islets of ...the beta granules alongside the insulin molecule from which it is released into the circulation simultaneously, molecule per molecule, whenever insulin secretion is ...
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A Note on the Beta Function And Some Properties of Its Partial Derivatives
... t x − 1 (1 − t) y − 1 dt (1) for Rex > 0 and Rey > 0. It is often applied in many fields such as mathematical equations and probability theory. Its definition was extended to complex numbers values of x and y by ...
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A generalized beta function and associated probability density
... incomplete beta functions associated with the func- tion defined by ...generalized beta functions are used to study some statistical functions in later ...density function (pdf) involving the ...
12
Activation of the human beta globin promoter in K562 cells by DNA sequences 5' to the fetal gamma or embryonic zeta globin genes
... the beta-globin gene in these cells. In contrast, a gamma/beta promoter composed of a gamma fragment spanning positions -408 to -137 joined to the 127-bp beta promoter was able to drive the ...
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OGTT A PRELIMINARY APPROACH TO DETECT IMPAIRED GLUCOSE TOLERANCE IN CHRONIC PANCREATIC DISORDERS
... In chronic pancreatic disorders like chronic pancreatitis, pancreatic tumours the beta cells of pancreas were damaged due to repeated inflammation. And pancreatic carcinoma predisposes to diabetes by secreting ...
6
Prolonged exposure of human pancreatic islets to high glucose concentrations in vitro impairs the beta cell function
... The aim of the present study was to clarify whether prolonged in vitro exposure of human pancreatic islets to high glucose concentrations impairs the function of these cells. For this purpose, islets isolated from ...
7
The role of beta cell glutamate receptors in pancreatic endocrine function and in the pathogenesis of type 1 diabetes mellitus
... Chapter One Thesis Introduction 83 activity of GAD65, one of the main β-cell antigen targets in autoimmune T1DM. Though increased activity of GAD is likely to enhance conversion of glutamate to GABA to reduce ...
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Beta cell mass and growth after syngeneic islet cell transplantation in normal and streptozocin diabetic C57BL/6 mice
... recipients, beta cell replication remained normal but beta cells underwent atrophy and mass in the graft was substantially ...mice beta cell replication and mass remain ...in ...
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