Beta cell mass and ECM proteins
Transplanted beta cell response to increased metabolic demand Changes in beta cell replication and mass
... J Clin Invest. 1994;93(4):1577-1582. https://doi.org/10.1172/JCI117137. We determined the capacity of transplanted beta cells to modify their replication and mass when stimulated by changes in metabolic ...
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Increasing beta cell mass to treat diabetes mellitus
... insulin-secreting beta cells is evident in ...rodent beta cells. The augmentation of beta cell proliferation is supposed to reverse ...human beta cells pose difficulty in promoting the ...
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Changes in extracellular matrix (ECM) and ECM-associated proteins in the metastatic progression of prostate cancer
... versus ECM factors in the migration and downstream establishment of boney metastases will be to examine the behavior of these vari- ous cells types in structured mutlicellular ...target proteins can be down ...
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Signals from the neural crest regulate beta cell mass in the pancreas
... regulate beta-cell mass in the pancreas Nada Nekrep 1 , Juehu Wang 1 , Takeshi Miyatsuka 1 and Michael ...insulin-expressing beta-cells increased in the Phox2b –/– ...the ...
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A simple matter of life and death : the trials of postnatal beta cell mass regulation
... Pancreatic beta-cells, which secrete the hormone insulin, are the key arbiters of glucose ...Defective beta-cell numbers and/or function underlie essentially all major forms of diabetes and must be ...
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The development of a GPR44 targeting radioligand [11C]AZ12204657 for in vivo assessment of beta cell mass
... per cell factory) and detached by the addition of 50 mL per cell factory of ice-cold mem- brane homogenization buffer [20 mM HEPES (pH ...per cell factory used and the protein content ...
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Beta cell mass and growth after syngeneic islet cell transplantation in normal and streptozocin diabetic C57BL/6 mice
... the beta cell mass in the graft and lead to failure of the ...of beta cell replication and mass after transplantation of insufficient, minimally sufficient, or excessive islet ...
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SPECT-OPT multimodal imaging enables accurate evaluation of radiotracers for beta-cell mass assessments
... -cell mass (BCM) and function is not clear and therefore, routine immunological and functional tests are not suitable to monitor changes in BCM 2–4 ...
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Landscape of Eukaryotic Transmembrane Beta Barrel Proteins
... β-barrel proteins into the outer ...peripheral proteins, SAM35 and SAM37 20,59 ...for cell viability 20,60,61 and, also, a conserved loop six, which promotes β-signal binding of the ...
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Electrochemical Deposition Stripping Analysis of Molecules and Proteins by Online Electrochemical Flow Cell/Mass Spectrometry
... necessarily proteins or peptides and can also be chemical or biochemical entities, provided they can be accumulated (specifically or nonspecifi- cally) on a ligating agent bound to the ...of proteins as ...
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Detection of amplifiable mRNA extracellular to insulin producing cells: potential for predicting beta cell mass and function
... insulin-producing cell lines in culture appar- ently pass many gene transcripts into the extracellular environment and that these transcripts can be reproduc- ibly ...given cell line into the medium may be ...
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High beta-cell mass prevents streptozotocin-induced diabetes in thioredoxin-interacting protein-deficient mice
... to cell death induced by direct exposure to STZ or to the combination of inflammatory cytokines interleukin-1, interferon-␥, and tumor ne- crosis ...-cell mass and influences insulin secre- ...
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Islet autoimmunity identifies a unique pattern of impaired pancreatic beta-cell function, markedly reduced pancreatic beta cell mass and insulin resistance in clinically diagnosed type 2 diabetes
... fat mass and fat-free ...in beta cell mass as well as presence of autoimmune-associated pattern A pathology in subjects with either islet autoantibodies or the DR3/DR4 ...reduced beta ...
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Micropatterns on Polyacrylamide Hydrogel for Controlled Cardiomyocyte Attachment using PLL PEG and ECM Proteins
... 1.2 Drug development The discovery of new drugs for any disease is a large field of research, and the most important part of the drug is its safety and t therapeutic effect. Therefore, drug discovery requires multiple ...
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Endothelial transcytosis of myeloperoxidase confers specificity to vascular ECM proteins as targets of tyrosine nitration
... enhanced cell surface binding under 4°C con- ditions, as well as a result of cold-induced retraction of the cytoskeleton directly exposing the subendothelial matrix to ...to cell surface glycosaminoglycans, ...
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Early peroxisome proliferator-activated receptor gamma regulated genes involved in expansion of pancreatic beta cell mass
... b-cell mass expansion for future comparison with the POKO mouse which is unable to expand its ...to cell proliferation and survi- val ...b-cell mass in POKO ...in cell cycle ...
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1 Mass Spectrometry of Amino Acids and Proteins
... in cell culture) [3], or enzymatic incorporation of 18 O water ...abundant mass spectral signal, the sample is likely to be exceedingly radioactive, the instrumentation would have become contaminated, and ...
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glucagon is essential for alpha cell transdifferentiation and beta cell neogenesis
... Indeed, it has recently been shown that hyperplasia of α cells in Gcgr knockouts can be phenocopied by tissue-specific knockdown of the glucagon receptor in hepatocytes (Longuet et al., 2013), revealing that a ...
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Characterization of the TGF-beta signalosome and of TGF-beta-dependent endometrial cell proliferation
... Up to date, the connection between the TGF-β pathway and the apoptotic pathways still remains unclear. Since TGF-βs are increased in the serum and peritoneal fluid of women with endometriosis and their levels are ...
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Computational design of [beta] sheet proteins
... residues further away from the mutation site did not change, and therefore it was possible to use values saved from the previous repacking simulation. The modified protocol was 1.5 times faster, and gave the same results ...
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