Biosynthetic Pathways
Retention and Loss of Amino Acid Biosynthetic Pathways Based on Analysis of Whole-Genome Sequences
... using biosynthetic pathways inherited from their bacterial ...the biosynthetic pathways and their respective enzymes are well characterized, orthologs can be recognized in whole genomes to ...
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Directed evolution of biosynthetic pathways to carotenoids with unnatural carbon backbones
... product biosynthetic pathways is the extensive use of enzymes with broad substrate and product ...isoprenoid biosynthetic enzymes, for example, accept a variety of both natural and unnatural ...
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Yeast artificial chromosomes employed for random assembly of biosynthetic pathways and production of diverse compounds in Saccharomyces cerevisiae
... Here we present a novel and conceptually different strat- egy for in vivo synthesis of natural compounds facilitating access to the chemistry of natural compounds, in particu- lar from the eukaryotic world. It allows the ...
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High-yield method for isolation and culture of endothelial cells from rat coronary blood vessels suitable for analysis of intracellular calcium and nitric oxide biosynthetic pathways
... High-Yield Method for Isolation and Culture of Endothelial Cells from Rat Coronary Blood Vessels Suitable for Analysis of Intracellular Calcium and Nitric Oxide.. Biosynthetic Pathways.[r] ...
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Responses of Synechocystis sp. PCC 6803 to heterologous biosynthetic pathways
... its biosynthetic pathway involves two cytochrome P450s that convert tyrosine into p-hydroxymandelonitrile and a UDP-glycosyltransferase that transfers a glucose from UDP-glucose ...three biosynthetic ...
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Engineering Biosynthetic Pathways in Cell-Free Systems for Sustainability and Chemical Innovation
... a biosynthetic pathway can be analyzed in less than eight hours, which is a fraction of the time it takes for total biosynthesis in vivo (shown in Figure ...prototyping biosynthetic pathways in ...
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Mining microbial genomes for new natural products and biosynthetic pathways
... of biosynthetic system, substrate specificity cannot be predicted with any degree of confidence from bioinformatics ...cryptic biosynthetic pathways and more generic approaches are ...cryptic ...
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Structural and biochemical studies on the biosynthetic pathways of cyanobactins
... The C-terminal cleavage of the modified core peptide is catalysed by the PatG subtilisin-like protease domain (PatGmac). This process occurs after both heterocyclisation (PatD) and N-terminal cleavage (PatApr) because ...
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Homocysteine induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways
... cholesterol biosynthetic pathway, including HMG- CoA reductase, IPP isomerase, and FPP synthase, were increased and peaked between 2 and 4 hours in HepG2 cells after treatment with homocysteine (Figure ...
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Reconstruction of cytosolic fumaric acid biosynthetic pathways in Saccharomyces cerevisiae
... We considered that fumarate can be accumulated and excreted by R. oryzae through reductive reactions of the tricarboxylic acid cycle [19,20], and asked whether S. cerevisiae can accumulate fumarate by a completely ...
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Mitochondria as biosynthetic factories for cancer proliferation
... and biosynthetic needs to grow, proliferate, and survive within the phys- ical constraints of energy and mass ...for biosynthetic pathways, including those executed within ...mitochondrial ...
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Biosynthesis of food constituents: Vitamins 2 Water soluble vitamins: Part 1 a review
... accepted biosynthetic pathways that lead to water-soluble vitamins in microorganisms, plants and some ...The biosynthetic pathways leading to the B-group vitamins (thiamin, riboflavin, ...
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Three-pathway combination for glutathione biosynthesis in Saccharomyces cerevisiae
... three pathways is a novel method for GSH produc- tion. Genes of three pathways were uniformly regulated and expressed by exactly the same strategy to evalu- ate synthetic capacities of engineered strains ...
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Understanding and manipulating plant lipid composition: metabolic engineering leads the way
... targeted pathways that use only acyl-CoA sub- strates to produce novel oils, bypassing the intricacies of unusual fatty acid biosynthetic pathways involving PC- linked ...step biosynthetic ...
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Wever_unc_0153D_16314.pdf
... RiPP biosynthetic pathways; 46 these domains have homology to PqqD, an accessory protein needed for leader peptide binding of the precursor PqqA in the pyrroloquinoline quinone ...
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A Single Biosynthetic Gene Cluster Is Responsible for the Production of Bagremycin Antibiotics and Ferroverdin Iron Chelators
... Genome sequencing of secondary-metabolite-producing microorganisms has re- vealed an enormous potential to increase the known chemical space (5), with the promise of new leads in human therapies or for sustainable ...
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The use of proteasome inhibitors in anti-cancer therapy
... complementary pathways of intracellular degradation are present in eukaryotic ...regulating biosynthetic pathways, proteins regulating the course of the cell cycle, many transcription factors, ...
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Engineering microbial cell factories for the production of plant natural products: from design principles to industrial-scale production
... Plant natural products (PNPs) are widely used as pharmaceuticals, nutraceuticals, seasonings, pigments, etc., with a huge commercial value on the global market. However, most of these PNPs are still being extracted from ...
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Functional and structural genomics of amino acid metabolism in Streptomyces coelicolor
... In contrast to the isomerisation catalysed by PriA, in which an enzyme is shared by two amino acid biosynthetic pathways, several paralogous enzymes with the potential to account for the[r] ...
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IMG ABC: A Knowledge Base To Fuel Discovery of Biosynthetic Gene Clusters and Novel Secondary Metabolites
... novel pathways involved in secondary metabolism, pre- dominantly because of the absence of tools that facilitate this intellectually and computationally difficult ...putative biosynthetic gene ...phenazine ...
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