Bleomycin-induced lung fibrosis
Transient gene transfer and expression of Smad7 prevents bleomycin induced lung fibrosis in mice
... into lung by adenoviral vectors prevented bleomycin-induced lung fibrosis, suggesting the therapeutic potential of Smad7 to prevent tissue ...tissue fibrosis in various human ...
8
CDK4/6 inhibition enhances pulmonary inflammatory infiltration in bleomycin-induced lung fibrosis
... prevented bleomycin-induced lung fibrosis. Bleomycin-treated mice were co-treated with palbociclib (PD 0332991, 150 mg/kg/day) in a preventive fashion ...
5
Longitudinal assessment of bleomycin-induced lung fibrosis by Micro-CT correlates with histological evaluation in mice
... of fibrosis measured by Micro-CT correlated with Ashcroft score, the percentage of collagen content and the percentage of alveolar air area (r 2 = ...pulmonary fibrosis and that its use could translate into ...
10
Arsenic trioxide inhibits transforming growth factor-β1-induced fibroblast to myofibroblast differentiation in vitro and bleomycin induced lung fibrosis in vivo
... were induced by TGF-β1 (α-SMA: ...also induced by TGF-β1 (CTGF: ...pulmonary fibrosis [6,18]. Pretreatment of ATO decreased TGF-β1-induced expression of CTGF and PAI-1 mRNA (CTGF: ...were ...
14
Deficiency of α7 Nicotinic Acetylcholine Receptor Attenuates Bleomycin-Induced Lung Fibrosis in Mice
... TGF-β1–induced lung profibrotic genes in mouse lung primary ...mouse lung primary fibro- blasts. The cultured mouse lung primary fibroblasts were labeled with or without rabbit anti- ...
16
Induced pluripotent stem cell-derived lung alveolar epithelial type II cells reduce damage in bleomycin-induced lung fibrosis
... the lung weight showed a significant decrease in the iPSC-AEC2 trans- planted group compared with the BLM group, suggest- ing less fibrosis ...BLM- induced lung ...of lung ...
12
The Role of Catalase in Pulmonary Fibrosis
... of lung cata- lase in human IPs (Figure ...to fibrosis varies among the different strains of mice ...apparent lung fibrosis after bleomycin administration is consistent with the ...
13
Serum extracellular vesicular miR-21-5p is a predictor of the prognosis in idiopathic pulmonary fibrosis
... the pre-normalized fold-changes of serum EV micro- RNAs (Additional file 1: Table S3) in addition to the post-normalized fold-changes generated by dividing the pre-normalization values by the EV amounts in the serum ...
15
pDCs in lung and skin fibrosis in a bleomycin-induced model and patients with systemic sclerosis
... and bleomycin-injected B6 mice (Figure 4, Supplemental Figures 1 and 2), one cannot exclude some unknown, off-target effects of anti–PDCA-1 ...in fibrosis. Second, the bleomycin model, like other ...
18
Characterization of lung stem cell niches in a mouse model of bleomycin-induced fibrosis
... the lung indicated that exogenous progeni- tors from the circulation contribute to lung regeneration; (2) most non-stem cells (possibly accessory cells) were non-hematopoietic in origin indicating that ...
21
MicroRNAs in fibrosis: opportunities and challenges
... in lung fibro- sis in both a TGF-β- and Smad3-dependent manner ...from fibrosis induced by bleomycin, confirming its regula- tion by ...and fibrosis are aggravated by genetic renal loss ...
10
Regenerative Potential of Adult Lung Spheroid Cells in a Bleomycin-Induced Pulmonary Fibrosis Rodent Model
... Briefly, explant sections similarly sized to a lung biopsy were taken from the distal lung section obtained and sliced into smaller sections. These sections were then washed with phosphate-buffered saline ...
65
Ovalbumin-induced plasma interleukin-4 levels are reduced in ceramide kinase-deficient DO11.10 RAG1-/- mice
... A bleomycin-induced fibrosis model, where IL- 13 is key, also did not show differences between Cerk -/- and WT control littermates (data not ...sole lung pathology where we observed a ...
6
Bleomycin induced pulmonary fibrosis in fibrinogen null mice
... the lung vascular bed was perfused with PBS, and the lungs were excised, minced, and digested enzymatically with digestion solution (RPMI 1640, 1 mg/ml collagenase, and 30 U/ml DNase) at 37°C for 30 ...mesh. ...
11
Increased expression of lung TRPV1/TRPA1 in a cough model of bleomycin-induced pulmonary fibrosis in Guinea pigs
... stress, fibrosis in the process of pulmonary fibro- sis may induce remodelling of sensory afferent fibres and neurogenic inflammation, upregulate the expression of TRP ion channels and increase cough ...in ...
11
Bleomycin Induced Diffuse Interstitial Pulmonary Fibrosis in Baboons
... of bleomycin and were terminated 6 mo after ...restrictive lung disease, but lung histology was nearly normal. Lung weight, total protein, and DNA had returned to control values, but collagen ...
11
Gelatinases Increase in Bleomycin-induced Systemic Sclerosis Mouse Model
... and fibrosis formation ...and lung were deparaffinized and ...In lung tissues, percent of α- SMA positive areas were calculated by imageJ software in images of 10 random microscopic fields, then the ...
8
Resolution of organ fibrosis
... Lung fibrosis. Fibrosis of the lung is associated with diverse etiologies, including scleroderma (systemic sclerosis), sarcoid- osis, infections, and exposure to toxicants or ...pulmonary ...
12
Depletion of club cells attenuates bleomycin-induced lung injury and fibrosis in mice
... Gene ontology analysis showed that the biological process terms “response to wounding,” “inflammatory response,” and “defense response” were significantly downregulated in bleomycin-injected mice with club cell ...
9
EM703 improves bleomycin-induced pulmonary fibrosis in mice by the inhibition of TGF-β signaling in lung fibroblasts
... legends. Bleomycin was administered intravenously to the mice on day ...the lung tissues by reverse transcriptase (RT)-polymerase chainreaction (PCR) on day ...the lung tissues on day ...murine ...
13