Blood-Brain Barrier Structure and Function
Impact of Docetaxel on blood-brain barrier function and formation of breast cancer brain metastases
... [4–7]. Brain metastases (BM) are the most common intracranial tumors in adults being al- most up to ten-fold more common than primary brain tumors and some primary tumors, among others BC, ex- hibit a ...
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What is the blood brain barrier (not)?
... The immune privilege of the central nervous system is indispensable for damage limitation during inflammation in a sensitive organ with poor regenerative capacity. It is a longstanding notion which has down the years ...
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Genetic mouse models to study blood–brain barrier development and function
... In the CNS, when Shh is overexpressed in the dorsal neural tube of embryos, Shh transgenic mice display a hypervascularization [110]. Alvarez and colleagues described how the Hh pathway contributes to the main- tenance ...
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Claudin-12 is not required for blood–brain barrier tight junction function
... WT brain tissue (Fig. 2). In the brain tissue from Tie2-lacZ mice, we detected abundant β-galactosidase activity in the endothelial cells of the vasculature in the ...
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A perfused human blood–brain barrier on-a-chip for high-throughput assessment of barrier function and antibody transport
... As a large portion of endocytosed TfR has been shown to remain in the endothelial cells instead of undergoing transcytosis, it is likely that a relatively large quantity of endocytosed MEM-189 remains within the ...
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The blood brain barrier in neuropsychiatric disorders
... for brain-wide knockdown of ...entire brain produced permeability of the BBB that resulted in impairments in learning and memory and increased ...in brain endothelial ...
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Basement membrane and blood–brain barrier
... CollAgen IV Collagen IV, the most abundant component of the BM, is a trimeric protein containing three α-chains. Currently, six collagen IV α-chains (COL4A1–6) have been identi- fied. 35–37 Unlike COL4A3–6, which are ...
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The brain structure and function
... The brain is contained within the skull, which protects it. Between the brain and the skull there are three layers of membrane called the meninges (see diagram on page ...the brain and spinal cord ...
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Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor
... drug structure—they cannot provide information as to the efficacy of the drug in question or whether the drug itself may influence BBB ...and function; however, each still leaves room for improve- ment to ...
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Update on the Role of the Blood-Brain Barrier in Damage to Immature Brain
... Cremer JE, Cunningham VJ, Pardridge WM, et a!: Ki- netics ofblood-brain barrier transport ofpyruvate, lactate and glucose in suckling, weanling and adult rats. Pulsinelli WA, Waldman S, [r] ...
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Entry of Bilirubin into the Brain Due to Opening of the Blood-Brain Barrier
... Serum albumin readily enters the brain following osmotic opening of the blood-brain barrier.25 How- ever, the albumin concentration varies within the brain, and the regional pattern appr[r] ...
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Blood-brain barrier derangement after electrical brain stimulation
... Noninvasive brain stimulation methods, including repetitive transcranial magnetic stimulation and transcranial direct current stimulation (tDCS), have received considerable attention in recent years for use in the ...
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Blood-brain Barrier Remodeling during Brain Metastasis Formation
... The brain is considered a sanctuary site for metastatic tumor growth, where the blood–brain barrier (BBB) and other components of the brain microenvironment, provide protection to the ...
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Current concepts of blood brain barrier development
... a brain-specific capability to access hematogenous factors in the circulation that modulate neural characteristics including turnover of adult neural stem ...
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The blood brain barrier in systemic infection and inflammation
... vascular blood–brain barrier is a highly regulated interface between the blood and ...primary function is to protect central neurons while signaling the presence of systemic in ...
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Blood brain barrier regulation in psychiatric disorders
... 3.1.1. Post-mortem studies in schizophrenia Several early studies focussed on post-mortem analysis of brain capillaries from control and schizophrenia individuals. Post-mortem studies have often been limited by ...
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How Glutamate Is Managed by the Blood-Brain Barrier
... Figure 1. Diagrammatic representation of the blood-brain barrier and isolated luminal and abluminal membranes. The BBB exists at the level of the endothelial cells of cerebral capillaries. The ...
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Histochemistry of liposomes and their association with the blood-brain barrier
... Vieira, Débora B i Lionel F Gamarra (2016). „Getting into the brain: liposome-based strategies for effective drug delivery across the blood–brain barrier”. International Journal of ...
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Blood-brain barrier permeability and physical exercise
... Brain and peripheral inflammatory states can also pro- mote BBB failure through tryptophan (TRP) catabolism as a consequence of kynurenine pathway activation, which is also connected with glutamatergic ...
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Possible strategies to cross the blood–brain barrier
... the brain and are also able to reach the CNS by intraperitoneal, intranasal, and oral administrations ...g7-NP brain delivery capacity using a model drug (FITC-albumin) with a high molecu- lar weight, ...
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