BMP/WNT signaling
The CCN family member Wisp3, mutant in progressive pseudorheumatoid dysplasia, modulates BMP and Wnt signaling
... inducible signaling pathway protein 3 (WISP3) cause the autosomal-recessive skeletal disorder progressive pseudorheumatoid dysplasia ...and Wnt signaling in developing ...inhibited BMP and ...
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Canonical Wnt signaling induces BMP-4 to specify slow myofibrogenesis of fetal myoblasts
... canonical Wnt signaling in myogenic differentiation and skeletal myofiber ...canonical Wnt signal- ing is most active during perinatal myogenesis and only activated in slow myofibers with high ...
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BMP and non canonical Wnt signaling are required for inhibition of secondary tail formation in zebrafish
... (BMP) signaling in specifying cell fate in the zebrafish tailbud has been well ...compromised BMP signaling produce an additional phenotype: a ventrally located secondary tail containing both ...
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YAP promotes neural crest emigration through interactions with BMP and Wnt activities
... of BMP/YAP were reported to cooper- ate to promote tissue growth [70] and YAP was demon- strated to induce BMP in several cell types while also repressing canonical Wnt signaling by ...
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Glypican4 promotes cardiac specification and differentiation by attenuating canonical Wnt and Bmp signaling
... that Bmp signaling is enhanced in the anterior lateral plate mesoderm of knypek/gpc4 mutants and that genetic inhibition of Bmp signaling rescues the cardiomyocyte differentiation defect ...
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Impaired neurodevelopmental pathways in autism spectrum disorder: a review of signaling mechanisms and crosstalk
... HH signaling increases NRP1 transcription and NRP1 is also reported to increase the activation of HH target genes by mediating HH trans- duction between activated SMO and SUFU [168, ...and WNT pathways has ...
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Genomic integration of Wnt/β catenin and BMP/Smad1 signaling coordinates foregut and hindgut transcriptional programs
... factor signaling controls cell fate decisions, but how these signals coordinate gene expression at the genomic level is poorly ...how BMP and Wnt signaling, which are differentially active ...
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On growth and form: a Cartesian coordinate system of Wnt and BMP signaling specifies bilaterian body axes
... a Wnt-BMP double gradient, indicates the pervasive integration of distant morphological ...the Wnt- BMP double-gradient profiles also orchestrate morphological transformations that span the ...
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BMP signaling induces digit regeneration in neonatal mice
... A major goal of regeneration studies is to design practical approaches to stimulate a clinically relevant regenerative response. The strategies for regenerative medicine are many and include the bioengineering of tissues ...
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FoxD1 protein interacts with Wnt and BMP signaling to differentially pattern mesoderm and neural tissue
... of BMP antagonism, neuralizing the embryo to control anterior neural cell ...of BMP antagonism to induce dorsal mesoderm cell fates, such as muscle and noto- ...local signaling environment, having ...
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Activation of WNT and BMP signaling in adult human articular cartilage following mechanical injury
... of WNT signaling in the context of joint surface defect repair is still poorly ...canonical WNT signaling on chondro- genesis, in experimental models utilizing adult cells, the activation of ...
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Embryonic signaling centers expressing BMP, WNT and FGF proteins interact to pattern the cerebral cortex
... telencephalic signaling centers ...of BMP and WNT genes, is expanded in mice lacking the Lim homeobox domain transcription factor, LHX2 (Bulchand et ...among signaling molecules and ...
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The non canonical BMP and Wnt/β catenin signaling pathways orchestrate early tooth development
... and Wnt signaling pathways play a crucial role in organogenesis, including tooth ...of BMP and Wnt pathways in early tooth development using a transgenic noggin (Nog) overexpression model ...
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Cellular and molecular mechanisms of tooth root development
... -catenin-mediated Wnt signaling is required to regulate the differentiation of CNC- derived odontoblast cells during tooth formation, because tissue- specific inactivation of β -catenin in developing ...
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The involvement of the wnt signaling pathway and TCF7L2 in diabetes mellitus: The current understanding, dispute, and perspective
... the Wnt signaling pathway is that β-cat/TCF mediates not only the effect of Wnt ligands, but also other cell signaling molecules during adulthood, including insulin, IGF-1, as well as peptide ...
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Dual Strategy for Characterizing foxq1b.
... TGFβ1 signaling in mouse epithelial cells results in an increase in Foxq1 expression, demonstrating a positive ...TGFβ1 signaling pathway, enhance EMT during cancer progression (Feuerborn ...Foxq1 ...
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The Effects of Tracheal Occlusion on Wnt Signaling in a Rabbit Model of Congenital Diaphragmatic Hernia
... Congenital diaphragmatic hernia (CDH) is a birth defect that occurs in every 2000-4000 live births [1,2]. CDH occurs when a failure in the fusion of the diaphragm results in a diaphragmatic defect (DD) that allows ...
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Wnt signaling: a promising target for osteoarthritis therapy
... β-catenin signaling in specific chondrocytes of adult mice resulted in the development of an OA-like phenotype ...catenin signaling in Col2a1- or Agc1-expressing cells were shown to exhibit severe cartilage ...
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Novel therapeutic Strategies for Targeting Liver Cancer Stem Cells
... HCC and liver CSCs [175, 176]. Induction of tumor hypoxia combined with chemotherapy by transcath- eter transarterial chemoembolization has been widely used in treating unresectable HCC, but tumor re- sponse rate is ...
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BMP signaling regulates sympathetic nervous system development through Smad4 dependent and independent pathways
... superfamily signaling pathways (Hill, 2009; Massague et al., 2005). Tgf signaling does not appear to be involved in SNS development (Dudas et ...the BMP-specific ...that BMP activates ...
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