Bone morphogenetic protein 4
New association of bone morphogenetic protein 4 concentrations with fat distribution in obesity and Exenatide intervention on it
... Monophosphate-activated protein kinase; AST: Aspartate aminotransferase; BAT: Brown adipose tissue; BMP-4: Bone morphogenetic protein 4; BP: Blood pressure; CP: C-peptide; CRP: C ...
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Bone morphogenetic protein 4 regulates the budding site and elongation of the mouse ureter
... Bone morphogenetic protein 4 (BMP4), a member of the TGF-β superfamily of secretory signaling mole- cules, has been implicated in many aspects of embry- onic development, ranging from ...
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Evaluation of specific germ cell genes expression in mouse embryonic stem cell-derived germ cell like cells treated with bone morphogenetic protein 4 in vitro
... transmitting factor in male gonads is produced, which terminates cell cycle at G1, and prevents the cells from entering meiosis (4). Whether a meiosis-inducing factor (5) or an autonomous event is required for GCs ...
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Synergistic enhancement of bone formation and healing by stem cell–expressed VEGF and bone morphogenetic protein 4
... in bone formation and bone healing with ex vivo gene therapy using muscle-derived stem cells genetically engineered to express human bone morphogenetic protein-4 (BMP4), VEGF, or ...
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Enhanced in vivo osteogenesis by nanocarrier-fused bone morphogenetic protein-4
... Purified protein was digested with enterokinase (EK Max, Life Technologies, Carlsbad, CA, USA), fractionated on sodium dodecyl sulfate-polyacrylamide gel, and transferred to a polyvinylidene difluoride ...days. ...
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Hypertrophy is induced during the in vitrochondrogenic differentiation of human mesenchymal stem cells by bone morphogenetic protein 2 and bone morphogenetic protein 4 gene transfer
... BMPs for their potential use in cartilage regeneration including BMP-2, BMP-4, BMP-6 and BMP-7, which were shown to induce chondrogenic differentiation of mesenchymal progenitor cells and to up regulate the ...
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Bone morphogenetic protein 4 (BMP4) signaling in retinoblastoma cells
... Bone morphogenetic proteins (BMPs) - expressed in the developing retina – are known to be involved in the regulation of cell proliferation and apoptosis in several tumor ...
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The role of bone morphogenetic protein-4 in the developing chick eye
... A s already mentioned, BM Ps are members of the TGF-B superfamily. With the exception of GDF-3 which has six cysteine residues, the T G F-p C-terminal domain has seven conserved cysteines. The members of this family are ...
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Analysis of gene expression changes associated with human carcinoma-associated fibroblasts in non-small cell lung carcinoma
... ing bone morphogenetic protein 4 (BMP4) and transforming growth factor, beta 3 (TGFB3) are involved in the TGF-β signaling ...Gla protein (MGP) were hub ...
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Original Article Silencing of microRNA-340 promotes the odontogenic differentiation of induced pluripotent stem cells through upregulating BMP4
... with bone morphogenetic protein 4 ...matrix protein 1 (DMP-1) in iPSCs was detected by quantitative real-time PCR (qRT-PCR), Western blot, and immu- ...
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Intra articular delivery of adipose derived stromal cells attenuates osteoarthritis progression in an experimental rabbit model
... from bone marrow or other tissue sites, based on their capacity to influence and regulate different stages of cartilage repair, is a challenge of considerable appeal to ...and bone morphogenetic ...
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Structure and expression of the chicken bone morphogenetic protein-2 gene
... In short-term organ cultures of mouse limb buds stripped of the AER, FGF-4 can increase proliferation of cells in the bud that would otherwise have effectively stopped growing (Niswander and Martin, 1993a), and ...
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The essential role of bone morphogenetic protein (BMP) signaling in organogenesis
... luciferase reporters of the Cox2 promoter, -8653 to +53 bp, -7444 to +53bp, -1500 to +1 bp, and –371 to +70 bp. Putative Smad-binding sites are denoted. (B) MECs were transfected with luciferase reporter plasmids ...
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Blockade of bone morphogenetic protein signaling potentiates the pro inflammatory phenotype induced by interleukin 17 and tumor necrosis factor α combination in rheumatoid synoviocytes
... Isolation and culture of rheumatoid arthritis synoviocytes Synoviocytes were grown from synovial tissue samples ob- tained from RA patients undergoing joint surgery. The patients with RA fulfilled the American College of ...
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Genetic analyses of bone morphogenetic protein 2, 4 and 7 in congenital combined pituitary hormone deficiency
... Direct sequencing of BMP2 revealed 10 that have been previously reported. The non-synonymous SNP rs2273073, found to be heterozygous in one out of 19 analyzed sub- jects represents a T to G base pair exchange resulting ...
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Adult and iPS-derived non-parenchymal cells regulate liver organoid development through differential modulation of Wnt and TGF-β
... BMP: Bone morphogenetic protein; CXCR4 : C-X-X motif receptor 4; CYP: Cytochrome P450; DKK: Dickkopf-related protein; dpMSC: Dental pulp-derived MSC; ECs: Endothelial cells; EGM: ...
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Using poly(lactic-co-glycolic acid) microspheres to encapsulate plasmid of bone morphogenetic protein 2/polyethylenimine nanoparticles to promote bone formation in vitro and in vivo
... Our data also demonstrated that the pBMP-2/PEI effi- ciently transfect MC3T3-E1 cells (Figure 3). Importantly, the transfected cells, MC3T3-E1 cells, could produce human BMP-2 protein and increase gene expressions ...
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Paracrine effects of human amniotic epithelial cells protect against chemotherapy-induced ovarian damage
... (TGF-β), bone morphogenetic growth protein-4 (BMP-4) and so on ...fluorescent protein (GFP) migrated into the injured ovary and differ- entiated into follicle-stimulating hormone ...
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Organizing pneumonia in mice and men
... BMPs: bone morphogenetic proteins; BMPR1B: bone morphogenetic protein receptor type-1B; BO: bronchiolitis obliterans; BOOP: bronchiolitis obliterans organizing pneumonia; CCL2: C-C ...
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Genetic analyses in a cohort of 191 pulmonary arterial hypertension patients
... BMPR1B: bone morphogenetic protein receptor type 1B; BMPR2: bone morphogenetic protein receptor type 2; BWA: Burrow-Wheeler Aligner; CAV1: caveolin 1; CNV: copy-number variation; ...
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